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Showing 1 to 20 of 123 for “"aspartic acid"”.
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Influence of additives on stabilization and mineralization pathway of amorphous calcium carbonate nanoparticles
… precipitated in solution within a poly (acrylic acid) (PAA) matrix. AFM imaging revealed that the PAA-ACC nanoparticles are composed of ACC nanograins with embedded PAA. The influence of organic additives (glucose, aspartic acid, glutamic acid) and Ca2+ on the mineralization and stabilization of …
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The Synthesis of Amphiphilic Glycolipids as Potential Inhibitors of Bacterial Adhesion
… thesis. A variety of glycolipids based around an aspartic acid, aliphatic or aromatic scaffold were investigated. Chapter 1 describes the biological importance of glycolipids and how they can be utilised as anti-adhesion agents and immunomodulators. The concept of multivalency is also discussed, …
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Análisis de un proceso de ultrafiltración extractiva de aminoácidos utilizando contactores de fibras huecas
… and back-extraction for the recovery of amino acids (phenylglycine and aspartic acid) from dilute aqueous solutions has been investigated in the present work. The membrane assisted liquid extraction is a hybrid process which allows the integration in only one unit of the two steps involved in …
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FTIR study of carboxylic acids and tyrosines in bacteriorhodopsin
… near 10-5 in the spectral regions where amino acid residues are monitored. The excellent signal to noise ratio allowed detection of absorption changes of single amino acids during the photoreaction. Aspartic acids and glutamic acids in bR were monitored by 13C labeling. Tyrosines were monitored …
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AMP Deaminase 3 overexpression regulates cellular energetics and signaling for PGC-1α activation.
… 2,4 dinitrophenol (DNP). Nucleotides, amino acids, and proteins were extracted immediately after DNP treatment and measured by UPLC and Western Blot. To confirm DNP was not toxic, myotubes were washed, and samples were collected 1 h later for nucleotides and amino acids. To determine the …
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Characterization of Leucyl -Trna Synthetase From Homo Sapiens and Escherichia Coli in Aminoacylation, Amino Acid Editing and Interdomain Interactions
… discriminator and universally conserved aspartic acid that were mutationally characterized. Substitution of threonine to alanine uncoupled specificity similar to other LeuRSs. However, the introduction of bulky residues in the amino acid binding pocket failed to block deacylation of tRNA, …
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Molecular studies of peptides at solid-liquid interfaces
… model peptide (consisting of diblock units of aspartic acid and isoleucine residues) adsorbed at a charged model surface (consisting of CH₂ atoms) in vacuum, and in presence of various solvent compositions (by addition of cosolvents) to study the conformational and orientational aspects of …
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The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics
L-Glutamic acid and L-aspartic acid are believed to be the principal initiators of excitatory synaptic neurotransmission in the mammalian central system. A number of molecules of either natural or synthetic origin have been identified as possessing agonist or antagonist properties at glutamate …
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The Effects of Buried Ionizable Amino Acids on the Stability of Ribonuclease Sa
… stability contribution of buried ionizable amino acids in proteins. To study the stability contribution of a naturally occurring buried aspartic acid, two stabilized forms of RNase Sa designated 7S and 8S were used. In 7S, aspartic acid 79 has an elevated pK of 7.4 due to its location in the …
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Investigating the biosynthesis of fosfazinomycin
Phosphonic and phosphinic acid natural products are characterized by their carbon-phosphorus bonds, and exhibit a variety of bioactivities. Further, these compounds often contain unusual structural features, which arise from remarkable enzymatic transformations. One example comes from …
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Triggerable ligand presentation using caged-RGD
… that present a UV-labile caged-Arginine-Glycine-Aspartic Acid (RGD) ligand and evaluate the effects on cell activities. RGD is the minimal adhesive sequence of fibronectin. By dynamically modulating adhesive ligand presentation, the effects of temporal control on cell processes can be elucidated. …
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Synthetic Alkyl Glycolipids as Therapeutic Agents: Their Synthesis as Potential iNKT Cell Stimulators and their Anti- Microbial Properties
… cell stimulatory ligands. Simple glycolipids, L-aspartic acid based glycolipids, glycoglycerolipids and L-serine based glycolipids were explored. Simple galactosyl glycolipids containing O- and N-glycosidic linkages and L-aspartic acid based glycolipids were constructed as in Chapter 2 with a …
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Self Assembling Bioactive Materials for Cell Adhesion in Tissue Repair
… cholesteryl moieties and oligomers of lactic acid units were found to form single crystals when precipitated from hot ethanol and smectic liquid crystalline phases when cast as a film. Cell culture experiments on these films with 3T3 and 3T6 fibroblasts indicated that these ordered materials …
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The Synthesis and Characterisation of Novel Low Molecular Weight Gelators and their Applications in Electrospinning to Develop Biocompatible Materials and Tissue Scaffolds
… to biomedical fields. Amphiphilic lipoamino acids, squaramides and carbohydrates are useful starting materials to synthesise LMWGs because they provide functional groups that can form the intermolecular interactions necessary for the formation of supramolecular self-assembled structures. …
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Structural studies of Butirosin D and FrbG
… two is histamine (H14 and H163) residues and one aspartic acid (D16) residue coordinate a metal ion, believed to act in concert with another aspartic acid residue (D19) as the Lewis acid for the reaction to occur. Residues surrounding this relatively deep motif are likely to direct both ligand …
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Characterization of leucyl-TRNA synthetase from homo sapiens and escherichia coli in aminoacylation, amino acid editing and interdomain interactions
… enzymes that charge tRNA with its cognate amino acid. In order to maintain fidelity during protein synthesis, editing mechanisms ensure that tRNAs are accurately charged. Leucyl-tRNA synthetase (LeuRS) has an editing active site that resides in a discrete domain called the connective polypeptide …
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A Species Comparative Study of the Soluble Phosphoproteins of Dentin.
… electrophoresis. They all showed high levels of aspartic acid, serine, and phosphate which is bound as phosphoserine. The data do not clearly suggest that a dentin phosphoprotein exists in the fish. The phosphoprotein of dentin may be a high molecular weight aggregate of greater than 150,000 …
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Developing test strips for naked-eye detection of alpha-hydroxy acids using indicator-displacement assays: an application of molecular recognition
… Two examples are the dihydroxylation of maleic acid and fumaric acid catalyzed by osmium tetroxide in water, and the hydrolysis of D-dimethyl tartrate. The assay employed a receptor that has 1,3,5-trisubstituted-2,4,6- triethylbenzene scaffold incorporating boronic acid and guanidinium moieties …
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Synthesis and Determination of the Absolute Configuration of the Bicyclic Guanidine Core of Batzelladine A and the Development of a Novel [4+2] Inverse Electron Demand Hetero Diels -Alder Cycloaddition and Its Application Toward the Synthesis of the Tricyclic Guanidine Fragment Within Batzelladine A
… protected form of the bicyclic core employing L -aspartic acid as the starting material. The development of a novel strategy for accessing the tricyclic guanidine portion within batzelladine A is also included within this study. We have identified a novel [4+2] inverse electron demand hetero …
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Racemization of Amino Acids in Teeth for the Determination of Age
… has focused on relating the extent of amino acid racemization in teeth to age. Past research has focused primarily on the analysis of aspartic acid due to its high racemization rate. Our research indicates that glutamic acid also shows promise as related to age determination. Results will be …
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