Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"arylsulfate"”.
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The Development of Sulfatase-Cleavable Linkers for Antibody-Drug Conjugates
… the design, synthesis and evaluation of arylsulfates as enzymecleavable ADC linkers. These arylsulfates were designed to be cleaved by lysosomal sulfatases, thus revealing a phenolate, primed for 1,6-elimination of a payload within the target cell (Figure 1A). Initially, a panel of model …
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The relationship of arylsulfatase C and the steroid sulfatases in mammals
Arylsulfatases (arylsulfate sulfohydrolase, EC 3.1.6.1) catalyze the hydrolysis of the O-S bond of sulfate esters. Two types of arylsulfatases have been described based on their subcellular distribution and biochemical properties. Arylsulfatase C, a Type I enzyme, shares many properties with the …
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Enzyme Kinetics of Recombinant Human Arylsulfatase B (rhASB)
… explain the enzyme kinetics of recombinant human Arylsulfate sulfatase B (rhASB) by using an in vitro bioassay and direct hydrolysis substrate assay to approach the problem of substrate limitation in establishing a representative kcat for rhASB. The project also explores the makeup of a possible …
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The Role of Periplasmic Disulfide Bond Status in the Regulation of the Salmonella SPI1 Type Three Secretion System
… DsbB, DsbL and DsbI, downstream of a periplasmic arylsulfate sulfotransferase (ASST). Here we show that DsbL and DsbI function as a redox pair for disulfide bond formation and, as such, affect transcription of the SPI1 type three secretion system genes and activation of the RcsCDB system. In …