Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"artificial pancreas"”.
-
Verification and Validation of Artificial Pancreas Systems Software
… privacy standards. This dissertation examines artificial pancreas systems (APSs) as an example of emerging open-source DIY medical software solutions. We focus on AndroidAPS, an Android-based APS implementation primarily written in Kotlin. We address the need for testing and validating the …
-
Synthesis, characterisation and biological activity of FITC-insulin for the development of an artificial pancreas
… labelled insulin in an implantable artificial pancreas (INsmart device) developed by Tayloret al, 2016, which is currently being tested in-vivo. The first objective of this thesis was to produce a fluorescein isothiocyanate (FITC)-insulin conjugatewhich shows equivalent biological …
-
The Artificial Pancreas in Children and Adolescents with Type 1 Diabetes: Bringing Closed-Loop Home
… 1 diabetes. Closed-loop insulin delivery (the artificial pancreas) is an emerging technology gradually progressing from bench to clinical practice. Closed-loop systems combine glucose sensing with computer-based algorithm informed insulin delivery to provide real-time glucose-responsive insulin …
-
Models and nonlinear control strategies for blood glucose regulation in artificial pancreas [Modelli e strategie di controllo non lineare per la regolazione della glicemia nel pancreas artificiale]
… e distrugge accidentalmente le cellule beta nel pancreas, limitando la capacità dell'organo di produrre insulina. Un pancreas artificiale è una tecnica che utilizza una pompa per somministrare la giusta quantità di insulina per via sottocutanea dopo aver analizzato i dati raccolti dai sensori, …
-
Chemical strategies for improving anti-diabetic glucagon therapy
The pancreas functions to carry out one of the most critical functions in the human metabolism, viz. glucose homeostasis. It achieves homeostasis by producing hormones including insulin and glucagon which act on different cell types to affect blood glucose concentrations. Under certain conditions, …
-
Evaluation of continuous glucose monitoring systems
… hopefully close the loop for a fully automated artificial pancreas and develop a cure for Type I diabetes.
-
Automating Health: The Promises and Perils of Biomedical Technologies for Diabetes Management
… technology used to manage T1D today, the Artificial Pancreas System (APS), to demonstrate how seemingly liberating automated biomedical technologies can entangle, subjugate, and confine those they aim to free. This study features the analysis of two distinct social groups by focusing on …
-
Second Generation Photoactivated Insulins
… variable fashion and can be automated as an artificial pancreas to avoid dosing errors. A first-generation material was constructed by covalently linking insulin to an insoluble polymer via a photocleavable group. Insolubility is a key requirement of the PAD material to allow retention at the …
-
In silico testing of glucose controllers : methodology and sample application
… concentration. An extracorporeal wearable artificial pancreas (AP) has been a research aim for over three decades. The research is motivated by the need to improve glucose control. Results of a major study, the Diabetes Control and Complications Trial (DCCT), have demonstrated that …
-
Closed-loop insulin delivery in adults with type 1 diabetes
… feasibility and safety of a closed-loop or ’artificial pancreas’ system linking insulin delivery with continuous glucose monitoring (CGM), in adults with type 1 diabetes in a controlled setting. Three randomised crossover studies compared closed-loop insulin delivery with conventional insulin …
-
Modeling, control and simulation of control-affine nonlinear systems with state-dependent transfer functions
… is variable because of fuel consumption, artificial pancreas and HIV drug delivery systems in the bio-medical field, robot arm and magnetic levitation systems in the mechanical engineering field and phase-locked-loop in the electrical engineering field. The subject of nonlinear system …
-
Efficacy and Feasibility of Fully Automated Closed Loop Insulin Pump Therapy after Islet Auto-Transplantation
Background: TPIAT may relieve pain from chronic pancreatitis while minimizing diabetes risk. Avoiding hyperglycemia minimizes islet apoptosis during engraftment. Closed Loop therapy may improve glycemic control in this population. Methods: Analysis of 14 patients (36% male; age 35.9±11.4 years) at …
-
Propuesta de un algoritmo de control en lazo cerrado para la diabetes tipo 1
… el desarrollo del denominado “páncreas endocrino artificial”. Este sistema consta de un sensor continuo de glucosa, una bomba de infusión de insulina y un algoritmo de control en lazo cerrado, la Tesis Doctoral se centra en la propuesta de un controlador. El objetivo del controlador es mantener la …
-
The impact of closed-loop insulin delivery on glucose control in children and young people with type 1 diabetes mellitus: Longer-term benefits across the paediatric age-spectrum
Type 1 diabetes is one of the most common chronic conditions of childhood and is characterised by a deficiency of insulin caused by immune-mediated destruction of pancreatic beta cells in genetically predisposed individuals. Despite increasing technology use to manage type 1 diabetes, most children …