Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"artificial cell"”.
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Engineering artificial cell membranes by Ting F. Zhu.
… division are essential biological processes of cellular life. A crucial question concerning the origin of cellular life is how primitive cells (protocells) lacking complex biological machinery could grow and divide. To address this question, we first developed an effective method for preparing …
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A Bottom-Up Approach to Building an Artificial Cell by Self-Assembly
… advances now allow the formation of minimal or artificial cells composed of a minimum number of components, capable of performing specific functions. New developments contributing to the complexity of artificial cells or making their design more cell-like increases the number of possible …
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Novel Bio-inspired Aquatic Flow Sensors
Inspired by the roles of hair cells in nature, this study aims to develop and characterize two new sets of novel flow sensors. One set of sensors developed and studied in this work are flow sensors fabricated using carbon nanomaterials. These sensors are made by embedding carbon nanotubes (CNT) and …
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DNA-based Artificial Mimics of Cell-surface Machinery
The plasma membrane of cells has evolved to mediate a broad array of functionalities critical to life, such as molecular trafficking, signal transduction, motility, adhesion and communication. These functionalities are often reliant on highly sophisticated membrane-anchored nano-machines, and …
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DEVELOPMENT OF ANTAGONISTS TARGETING CHEMOKINE RECEPTOR CCR5 AND THE CHEMOKINE RECEPTOR CCR5 – MU OPIOID RECEPTOR HETERODIMER
… integral role within the inflammatory network of cells. Importantly, CCR5 is a mediator in several disease states and can be targeted using small molecule antagonists. Within this work, CCR5’s role in prostate cancer and HIV/AIDS has been exploited in order to develop potential therapeutics and …
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Engineering synthetic biology routes for protein analysis using microfluidic systems
… applications mentioned. The ability to produce artificial membranes within a microfluidic platform is crucial for the realization of these advantages. Current methods of producing and studying artificial cell membranes are typically low-throughput and not automated.;This thesis presents the …
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Artificial Transmembrane Signalling
Cell membranes coordinate a large variety of biological processes by selectively recognising and responding to different external stimuli, and membrane-spanning proteins play a vital role in these signalling pathways. A large number of examples of synthetic membrane channels and transporters have …
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Photoelectrochemical tandem cells with enzymes wired to hierarchically-structured electrodes for solar fuel synthesis
… building blocks, releasing O2 as a by-product. Artificial photosynthesis attempts to mimic this process to produce a renewable and storable fuel, such as H2. Semi-artificial photosynthesis combines the strengths of natural photosynthesis with synthetic chemistry and materials science to develop …
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Engineering Internal and External Molecular Pathways in Artificial Cells
Bottom-up synthetic biology aims to engineer artificial systems exhibiting biomimetic struc- ture and functionality from the rational combination of molecular and nanoscale elements. These systems often take the form of artificial cells: micron-scale, cell-like constructs that display advanced …
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Exploring nanoparticles' interactions with blood proteins and visualizing the heterogeneity within hematopoietic cell populations
… of targeted drug delivery by recognizing target cells and selectively delivering the therapeutic drugs to these cells. However, functionalized-NPs often have low targeting efficiency when they are administered in vivo. One of the major causes of this unfavorable outcome is that proteins and other …
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Electrofusion of Escherichia coli with Giant Lipid Vesicles and the Compaction of Escherichia coli Nucleoid
… phenomenon observed in many aspects of cellular activities. To date, various methods have been developed for artificially inducing the fusion of biological and synthetic lipid membranes/vesicles to generate hybrid cells and hybrid synthetic lipid vesicles. Electric field-mediated fusion …
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Steroid receptor crosstalk in breast cancer cells.
… growth and survival of normal breast epithelial cells and breast cancer cells is promoted by estrogens and progesterone and both estrogen receptor (ER) and progesterone receptor (PR) have been shown to play prominent roles in breast cancer progression. It has also been demonstrated that …