Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"articular chondrocytes"”.
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Extracellular Nucleotides Induce Transient Elevation of Cytosolic Calcium in Articular Chondrocytes
… of nucleotides on P2Y receptor activity in live articular chondrocytes by monitoring changes in the concentration of cytosolic free calcium. ATP and UTP induced large transient elevations of calcium in the majority of cells tested (71 of 83 cells and 82 of 147 cells, respectively). In contrast, …
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The redox regulation of alpha 5 beta 1 integrin stimulated MMP production in articular chondrocytes
… and may contribute to the degradation of the articular cartilage extracellular matrix (ECM). ROS have been shown to serve as secondary messengers in integrin and cytokine signaling pathways which stimulate chondrocyte production of ECM-degrading enzymes called matrix metalloproteinases (MMPs). …
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Effects of sodium hyaluronate and triamcinolone acetonide on proteoglycan metabolism in equine articular chondrocytes treated with interleukin-1
… caused by interleukin-1 (IL-1) administration. Chondrocytes were collected from fetlock joints of ten horses euthanized for reasons unrelated to joint disease. Chondrocyte pellets were treated with media (negative control); media containing IL-1 only (positive control); or media containing IL-1 …
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Effects of biochemical and mechanical stimulation of articular chondrocytes in collagen-GAG scaffolds : extracellular matrix biosynthesis and scaffold stiffness
… certain types of mechanical loading can increase chondrocytes' ECM biosynthesis in particular cell-scaffold systems in vitro. Few if any loading experiments have been done, however, with type II collagen-GAG scaffolds cultured in serum-free medium. Chapter 3 describes a series of experiments in …
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Proliferative, contractile, and biosynthetic activity of adult canine articular chondrocytes in Type I and II collagen-glycosaminoglycan matrices in vitro
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2003.
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Investigation into the immuno-therapeutic potential of melanocortin peptides on activated chondrocytes
… isolated primary bovine and in situ bovine articular chondrocytes. Pro-inflammatory cytokines including IL-1β, IL-6, IL-8, TNF-α, produced by activated articular chondrocytes significantly up-regulate matrix metalloproteinases (MMPs) gene expression, and inhibit the chondrocyte’s …
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Exploring Chondrocyte Integrin Regulation of Growth Factor IGF-I Expression from a Transient pAAV Vector
… both mitogenic and anabolic responses in articular chondrocytes. While it has been shown that exogenous IGF-I can regulate chondrocyte integrins, little is known regarding regulatory effects of IGF-I produced from a transiently expressed plasmid based adeno-associated virus (pAAV) vector. …
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Development and Characterization of Photocrosslinkable Hyaluronic Acid Hydrogels for Cartilage Regeneration
… all preserved the rounded morphology of chondrocytes, but cell viability and neocartilage formation were dependent on hydrogel design, where increased crosslinking resulted in cell death and increased macromer molecular weight yielded inhomogeneities in cell and ECM distribution within …
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Impact of the DNA methyltransferase inhibitor, 5-azacytidine, on chondrocytic phenotype
… the age-related disease, osteoarthritis is of particular importance to current health issues. Osteoarthritis (OA) is a progressive, degenerative disease that affects articular cartilage, the synovial lining and adjacent bone of joints. OA currently affects over 30% of the US population. This …
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Selecting dietary-derived bioactives which protect cartilage from destruction in osteoarthritis
… that affects the whole joint, with progressive articular cartilage loss. Healthy cartilage must maintain a balance between extracellular matrix synthesis and degradation. Metalloproteinases (Matrix metalloproteinases, MMPs and a disintegrin and metalloproteinase domain with thrombospondin …
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Chondrocyte Regulation by IL-I and IGF-I: Interconnection Between Anabolic and Catabolic Factors
Articular cartilage functions to reduce the mechanical stresses associated with diarthrodial joint movement, protecting these joints over a lifetime of use. Tissue function is maintained through the balance between synthesis and resorption (i.e., metabolism) of extracellular matrix (ECM) by …
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Stiffness controls primary cilia position and length: mechanisms and potential in reversing osteoarthritis phenotypes
… well as cell and nuclei area over time in mouse articular chondrocytes. Contrary to other cell types, this study shows that chondrocyte primary cilia shorten on softer substrates demonstrating tissue-specific mechanosensing which is aligned with the tissue stiffness the cells originate from. This …