Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"articular cartilage degeneration"”.
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The Role of Piezo1 in Mediating Chondrocyte Cell Signaling and Senescence
… the leading cause of disability, is driven by articular cartilage degeneration and inflammation. Mechanosensitive ion channels PIEZO1 and PIEZO2 have been implicated in OA progression via calcium signaling in chondrocytes. This study investigates the role of conditional Piezo channel knockout …
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The Mechanism of Action of Hyaluronan Therapy as a Treatment for Osteoarthritis and the Assessment of Osteoarthritic Articular Cartilage Using Ultrasound
… (1) how hyaluronan (HA) therapy interacts with articular cartilage at the molecular and tissue level, and (2) whether quantitative ultrasound imaging can detect early degenerative changes in articular cartilage before irreversible osteoarthritic damage develops. By combining molecular …
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Biomechanical And Biological Evaluation Of A Model Of Post-Traumatic Osteoarthritis Following Noninvasive, Traumatic Rupture Of The Anterior Cruciate Ligament
… cause extensive degenerative joint changes, and articular cartilage degeneration was most profound in the medial compartment of the femur. The two models yield in a differential bony remodeling response, and surgical ACL transection causes more drastic degenerative changes of articular cartilage. …
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Quantitative Magnetic Resonance Imaging of Knee Articular Cartilage and Effusion-Synovitis: The Structural Response to Changes in Joint Loading
… in knee OA studies. Specifically, changes in articular cartilage composition and/or effusion-synovitis were examined in people with or at risk for knee OA and healthy controls, and after altering joint loads. Chapter 2 is a systematic review that studied articular cartilage composition using …
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Impact loading and functional tissue engineering of articular cartilage
… two advances for alleviating the problem of articular cartilage degeneration: mitigating degradative changes that follow mechanically induced injuries and growing functional neo-cartilage for diseased tissue replacement. Experiments demonstrate that cartilage subjected to a single, …