Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"arteriogenesis"”.
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Eph-mediated restriction of cerebrovascular arteriogenesis
… Enhancement of pial collateral remodeling (Arteriogenesis) has recently been shown to improve blood flow and mitigate neural tissue damage following stroke (1-3). Arteriogenesis is the remodeling of pre-existing arteriole vessel which are able to re-route blood to blood-deprived regions of …
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Therapeutic Targeting of Arteriogenesis Following Ischemic Stroke
… to expand through an adaptive process termed, arteriogenesis, allowing for retrograde perfusion into the obstructed artery and its affected tissue. However, hyperacute arteriogenesis following ischemic stroke has been poorly investigated. The following dissertation aims to address this research …
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Biomechanical regulation of arteriogenesis : defining critical endothelial-dependent events
… concern for Americans and people worldwide. Arteriogenesis, an adaptive remodeling process in which pre-existing collateral arterioles remodel to form large diameter conductance arteries, has received recent attention for its therapeutic potential in treating CHD, but the mechanisms …
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The Impacts of Sex and Myogenic Cell Transplantation on Collateral Capillary Arteriogenesis
… have a better prognosis, promoting collateral arteriogenesis is a potential PAOD treatment. Additionally, female PAOD patients have a worse response to treatment and a worse prognosis compared to males, which could be due to impaired collateralization. Cell transplantation is a potential …
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Unraveling the Role of EphA4 in Immune-Mediated Arteriogenesis After Ischemic Stroke
… occlusion. Their outward growth or remodeling (arteriogenesis) is essential for promoting cerebral reperfusion and preventing tissue damage after ischemic stroke. Increased fluid shear stress on collateral vessel wall activates arteriogenesis result in the activation of the endothelium and …
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The Impacts of Arterial Occlusion, Sex, and Exercise on Arteriogenesis and Functional Vasodilation
<p>The most frequent clinical presentation of peripheral arterial occlusive disease (PAOD) is intermittent claudication, which may be caused by impaired vasodilation. Patients demonstrate both local and systemic impairments in vasodilation, but as the collateral circulation is the primary site of …
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Impact of Primary Myoblasts on Macrophage Polarization In-Vitro
… flow to the ischemic tissue in a process called arteriogenesis, which has been studied as a therapeutic option. Cell-based therapies, such as BM-MNCs, have been investigated as means to enhance arteriogenesis, but have largely failed in clinical trials. An alternative cell-based therapy candidate …
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The Impact of Increased Collateral Flow on Transverse Arteriolar Microvascular Tree Morphology
<p>The goal of this study was to understand how arteriogenesis impacts transverse arteriolar tree structure. The previous process involved a vascular casting technique that utilized black India ink as the casting agent and manual measurement of vessel morphology with ImageJ. This study decreased …
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Microvascular Function and Remodeling Due to Chronic Changes Within the Skeletal Muscle Microenvironment
… which can undergo remodeling such as arteriogenesis, angiogenesis, or capillary rarefaction. Vascular remodeling requires the coordinated action of several factors within the microenvironment. These include: matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue …
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Sex Differences in Collateral Remodeling Following Hindlimb Arterial Occlusion
… not captured in our specific investigation of arteriogenesis, an evaluation of microvascular remodeling in the ischemic zone and collateral vasodilation would be of interest, as would evaluating arteriogenesis following oophorectomy with estrogen depletion. The determination of any underlying …
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Mathematical Models of Major Arterial Occlusion
… time scale and structural changes including arteriogenesis and angiogenesis on a long time scale. In the acute time frame, the responses that contribute most to changes in vascular tone are increases in flow and shear stress in collateral vessels and increases in metabolic signaling in distal …
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Design and use of an environmental control platform for studying vascular cell function in three-dimensional scaffolds
… through the processes of angiogenesis and arteriogenesis. Endothelial cells are the initial cells that migrate and proliferate during the process, followed by smooth muscle cell movement and differentiation. The recruitment of smooth muscle cells is not fully understood, and if understood …
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Endothelial Cell-Specific Knockout of Meis1 Protects Ischemic Hindlimb Through Vascular Remodeling
… mechanism of Meis1 in the regulation of arteriogenesis and angiogenesis using hindlimb ischemia model of transgenic neonatal mice. The long-term goal is to develop a new treatment for patients with PAD. Three separate but related studies were planned to complete the proposed research …
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Molecular imaging of spatio-temporal distribution of angiogenesis in hindlimb ischemia model and diabetic milieu
… although angiogenesis is pronounced in day 9, arteriogenesis is not sufficiently pronounced and that the phenomenon of arteriogenesis has just initiated. The study of the angiogenic response to ischemia, has not yet been completed as MI of diabetic animals with hindlimb ischemia is underway and …
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The role of fibroblast growth factor-2 (FGF2) in vascular remodeling and adaptation
… wildtype counterparts. Second, angiogenesis and arteriogenesis were not different between the ischemic limbs Fgf2⁺/⁺ and Fgf2⁻/⁻ mice, demonstrating that FGF2 is not required for vascular adaptation in response to ischemia. However, these experiments led to the observation that reactive hyperemia …
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Charakterisierung der stressinduzierten Genexpression in Endothelzellen - unter besonderer Berücksichtigung des Molekularen Chaperons Mdg1
Mit seinen 6000 m2 Oberfläche ist das <br>vaskuläre Endothel keine passive Barriere zwischen dem Blut und <br>der angrenzenden Gefäßmuskelschicht, sondern ein endokrin aktives <br>Organ. Es spielt eine Schlüsselrolle in der Signalvermittlung <br>zwischen Blut und Extravasalraum. Ein wichtiger …
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Die Bedeutung leukozytärer Subpopulationen für die Arteriogenese im Kaninchenhinterlauf
Die Chemoattraktion und Aktivierung von Monozyten durch spezifische Zytokine (MCP-1, TGF-ß) vermag die Entwicklung von Kollateralarterien nach Gefäßokklusion (Arteriogenese) signifikant zu beschleunigen. Diese Substanzen wirken jedoch nicht nur auf Monozyten, und die Beteiligung anderer …
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Einfluß von Wachstumsfaktoren und Wachstumsfaktorkombinationen auf Angio- und Arteriogenese am ischämischen Kaninchenmyokard : eine histologische Studie
Einleitung: Die Induktion von Gefäßwachstum zur Therapie ischämischer Krankheiten wie der koronaren Herzkrankheit ist Gegenstand der aktuellen Forschung und zeigt vielversprechende Ansätze. Das Ziel dieser Studie war, den Einfluss von VEGF-, FGF-2- sowie GM-CSF-Plasmid-DNA auf Angiogenese und …
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Effekte von Leptin- und MCP-1-Applikation auf funktionelle Parameter der Arteriogenese : eine experimentelle Studie mittels Ultraschallflussmessungen, Mikrosphärperfusion und Proliferationsanalyse
Untersuchungen zur Stimulation des Gefäßwachstums sind seit einigen Jahren Gegenstand intensiver Forschung. Die Methoden zur Erfassung einer verbesserten Gewebsperfusion variieren jedoch beträchtlich. Die verlässliche Erfassung der Arteriogenese ist die wesentliche Voraussetzung bei der Auswahl …
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