Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"arterial thrombosis"”.
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Development and experimental validation of a novel arterial thrombosis-on-a-chip microfluidic device
… a custom-designed PDMS-based chip, that triggers thrombosis with a collagen and tissue factor spot. These two substrates are exposed in vivo when an atherosclerotic plaque ruptures, and thus represent appropriate biological stimuli to trigger occlusive clot formation within an in vitro model. To …
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Arterial Thrombosis in Factor V Leiden or Activated Protein C Resistance. Clinical and Experimental Studies.
… documented in 20-60% of patients with deep vein thrombosis (DVT). Whether such propensity also exists in arterial circulation is still controversial. The general aim of the present thesis is to clearify some of the controversies that cloud the impact of APC resistance or Factor V leiden mutation …
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Vascular biology in the menstrual cycle, pregnancy and pre-eclampsia
… but significant in women of reproductive age. Thrombosis and thromboembolism are the most common causes of maternal death in the United Kingdom. Pre-eclampsia is associated with increase in immediate and lifetime risk of adverse thrombotic events. Both pregnancy and the follicular phase are …
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Characterization of platelet glycoprotein Ib-IX-V: von Willebrand factor interaction under shear conditions
Arterial thrombosis is one of the important pathophysiological mechanisms that lead to cardiovascular diseases. In this thesis, we have made an attempt to better characterize the kinetic and molecular mechanisms that underlie the critical first step in arterial thrombosis, namely, the interaction …
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Chrysophanol-8-O-glucoside Attenuates Platelet Activation Through Inhibiting MAPK and PKCε
Platelets are key components of thrombosis and may also participate in the progression of cardiovascular diseases. Hence, the inhibition of platelet aggregation is important for preventing the progression of arterial thrombosis. Rhubarb is a widely used traditional medicine and has been reported to …
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Mechanisms of platelet inhibition by the selective serotonin reuptake inhibitor citalopram
… the beneficial or adverse effects of SSRIs on arterial thrombosis are poorly characterised and detailed in vitro experimental data is limited. The SSRI citalopram is a racemate, the (S)-isomer being the more potent SERT inhibitor. Although citalopram has been shown to inhibit platelets in …
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Role of Monocytes and Neutrophils in Thrombosis
Arterial thrombosis is the major trigger of myocardial infarction and ischaemic stroke. Although platelets are the most abundant cell in arterial thrombi, platelets interact closely with leukocytes such as monocytes and neutrophils and modify their activity. This thesis aims to identify novel …
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Polyphosphate is a novel modulator of coagulation and inflammation and is a therapeutic target
… exciting new area of research in hemostasis and thrombosis focuses on how inorganic polyphosphate (polyP) can mediate many of these novel amplification steps and many of the connections between coagulation and inflammation. Additionally, the multiple procoagulant and proinflammatory roles for …
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Investigating small-molecule inhibitors of platelet aggregation
… The major cause of myocardial infarction is arterial thrombosis, driven by platelet aggregation. Adenosine diphosphate (ADP)-induced platelet aggregation is mediated by the Gi-protein-coupled receptor (GPCR), P2Y12. Therefore, P2Y12 antagonists are clinically used to prevent thrombotic …
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Novel applications of fluorine-18 labelled radiotracers in cardiovascular disease
… high-risk coronary plaque, coronary atherothrombosis, and aortic valve and myocardial disease. METHODS AND RESULTS: Cardiovascular ¹⁸F-fluoride positron emission tomography-magnetic resonance imaging: a comparison study: Eighteen patients with aortic stenosis or recent myocardial infarction …
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PATHOPHYSIOLOGY OF VON WILLEBRAND FACTOR IN BLEEDING AND THROMBOSIS
… to different thrombotic disorders such as arterial thrombosis, ischemic stroke and venous thromboembolisms. The dual role of VWF in both bleeding and thrombosis, with a focus on VWD and deep vein thrombosis (DVT), are discussed in this thesis. In the first part, we described the approach …