Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"arterial smooth muscle"”.
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T-type Calcium Channels in Arterial Smooth Muscle: Activity, Regulation and Function
… regulators of excitation-contraction coupling in arterial smooth muscle. Despite evidence of T-type CaV channels in rodent smooth muscle, little is known of their regulation and function. This thesis sought to delineate T-type Ca2+ channels, ascertain if they are regulatory targets of vasoactive …
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Mitochondrial Regulation of Arterial Contractility
… functions of mitochondria in contractile arterial smooth muscle cells are poorly understood. Mitochondria can uptake calcium (Ca<sup>2+</sup>), but intracellular Ca<sup>2+</sup> signals that regulate mitochondrial Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>mito</sub>) and …
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QUB-1331: a bioactive peptide from the skin secretion of the Chinese piebald odorous frog (Odorrana schmackeri)
… activity of the peptide on rat bladder smooth muscle, a dose-dependent relaxation on rat arterial smooth muscle and a BK inhibitor function on rat ileum. Besides, increased frequency of contraction was observed on rat uterus smooth muscle following application of this novel peptide. No …
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Development of a Microplate-Based Calcium Assay for Studying Desensitization of the P2Y2 Nucleotide Receptor
… to mediate P2Y2R desensitization in rat arterial smooth muscle cells, it was hypothesized that the human homologs would mediate P2Y2R desensitization in human 1321N1 cells. To test this hypothesis, a microplate-based calcium assay was developed and employed to functionally assess P2Y2R …
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Evidence for Absence of Latchbridge Formation in Phasic Saphenous Artery
Tonic arterial smooth muscle can produce strong contractions indefinitely by formation of slowly cycling crossbridges (latchbridges) that maintain force at a high energy economy. To fully understand the uniqueness of mechanisms regulating tonic arterial contraction, comparisons have been made to …
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Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension
… and apoptosis resistance of pulmonary arterial smooth muscle (PASMCs) and endothelial cells (ECs) has been attributed to the pathogenesis of pulmonary arterial hypertension (PAH). It is an incurable cardiovascular disorder, which leads to right heart failure and death, if left …
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Modulation of Cerebral Artery Smooth Muscle BK Channel Function by Neurosteroids
… such as controlling the contraction of smooth muscle, including cerebrovascular smooth muscle. Importantly, BK channels are made up of a homotetramer of α subunits which associate with accessory β subunits. These β subunits alter the activity of the channel; this modulation is …
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Vascular receptor changes in ischemic stroke
… in rats. In addition, rat cerebral arteries and arterial smooth muscle cells were cultured for further analysis of cerebrovascular receptor regulation. For functional studies of cerebral arteries, sensitive myographs were used. mRNA levels were quantitatively measured by real time PCR and protein …
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Expression and Function of Ca2+-Activated K+ Channels in Uterine Arteries
… BKCa and SKCa channels were expressed in uterine arterial smooth muscle cells and endothelial cells. Pregnancy selectively enhanced the protein abundances and mRNA levels of BKCa subunit 1 and SKCa subtype 2 and 3 in uterine arteries, resulting in enhanced both BKCa and SKCa channels activities …
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Investigating the Role of Phosphodiesterase 1C in Vascular Smooth Muscle Cell Migration and Invasion
Phenotypic plasticity of human arterial smooth muscle cells (HASMCs) allows them to transition from a “contractile/quiescent” state, in which they regulate arterial tone and blood pressure, to one in which these cells are more “synthetic/activated”. Synthetic/activated HASMCs are migratory and …
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Differential Cytotoxicity and Reactive Oxygen Species Generation in Pulmonary and Aortic Cells Exposed to Inorganic Arsenic and Monomethylarsonous Acid
… effects of iAs and MMAs on thoracic aorta smooth muscle cells (A7r5) and rat pulmonary arterial smooth muscle cells (rPASMC) in culture to look for the generation of malondialdehyde, hydrogen peroxide, and superoxide. Cytotoxicity was determined by cell counts and Trypan Blue exclusion, MTT …
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The role of mitochondria in regulating smooth muscle cell proliferation and migration in pulmonary hypertension
… with proliferation and migration of pulmonary arterial smooth muscle cell (PASMC) is the hallmark of pulmonary hypertension, a proliferative disease with poor prognosis, which is exacerbated by hypoxic conditions. Hyperproliferation of PASMC underlies the failure of current therapy directed at …
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Studies of vascular function in patients with heart failure and either preserved or reduced left ventricular systolic function
… of HF-PSF. Although there are limited data on arterial stiffness in HF-PSF, there have been no studies examining other parameters of vascular function in HF-PSF and vascular function has never been formally compared in cohorts of patients with HF-PSF and heart failure due to reduced LV systolic …
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Modulating Bone morphogenetic protein (BMP) and Transforming growth factor-beta (TGF-β) signalling with green tea catechins in mammalian cells
Familial cases of pulmonary arterial hypertension (PAH) are often caused by germline mutations, the most common being a loss of characteristic mutation in the BMPR2 gene, a member of the TGFβ Superfamily. In this study, it was hypothesised that these green tea catechin compounds might inhibit TGFβ …