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Showing 1 to 14 of 14 for “"arterial flow"”.
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Hydrodynamic Characterization of an Arterial Flow Bioreactor
An in vitro arterial flow bioreactor system for the generation of physiological flows in a biological environment was designed, constructed, and characterized. The design was based on models previously used to investigate the response of endothelial cells to shear. The model interfaces a bioreactor …
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Characterization of Arterial Flow for Junctional Bleeding Control
<p>This study investigated reducing volumetric flowrate under steady flow conditions by varying lengths of compression with constant cross-sectional area and varying cross-sectional area reduction with constant length in order to better understand how to control junctional hemorrhaging. The …
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Umbilical arterial flow analysis to determine an index of placental impedance
Umbilical flow velocity waveforms (FVW' s) can be measured non-invasively using Doppler ultrasound. Changes in the FVW's occur long before the warning signs from other conventional monitoring methods. Correct interpretation of the changes in the FVW has the potential of providing the clinician with …
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Seeding of Titanium Surfaces and Nitinol Stents with Blood-Derived Endothelial Cells
… be conducive to EC retention and function under arterial flow; and (3) nitinol stents seeded with ECs at the point of care will remain adherent and functional after stent deployment and arterial fluid shear stress conditions <italic>in vitro</italic> and <italic>in vivo</italic>. Based on the …
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The Evolution of Platelet Responses to Collagen Under Conditions of Hemodynamic Flow
… in platelets under conditions of rapid blood flow is unclear. Additionally, it is unknown if responses to collagen are conserved in nucleated thrombocytes found in non-mammalian vertebrates, which do not express GPVI. Here we show that the GPVI proline-rich domain accelerates GPVI signaling …
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Detection of Stroke, Blood Vessel Landmarks, and Leptomeningeal Anastomoses in Mouse Brain Imaging
… stroke recovery that allows additional blood flow through the affected area. However, few databases and algorithms exist for this specific task of locating them. In this paper, a MATLAB program is developed to find these connections and detect strokes to replace manual labeling by …
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Roles of coagulation factor XIII in the functions of blood platelets
… platelet accrual was preserved under venous and arterial flow conditions where both integrins played essential roles. Under these conditions, platelet adhesion to immobilised activated FXIII (FXIIIa) was apparent at a shearrate of 300s"1, significantly reduced at 800s"1, but absent above 1000s"1. …
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Antithrombotic agents under flow conditions
… proteins and blood cells under a wide range of flow rates. To mimic these conditions in vitro, a parallel plate flow chamber with human umbilical vein endothelial cells (HUVEC) or extracellular matrix (ECM) has been developed. A method to investigate thrombin generation (TG) in platelet rich …
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Assessment of Peripheral and Central Hemodynamics During Leg Exercise With "Blood Flow Restriction"
“Blood flow restriction” (“BFR”) is a type of exercise training where a pneumatic cuff is applied to the proximal portion of an exercising limb. In “BFR”, cuff inflation to 40% of an individual’s arterial occlusion pressure (AOP; cuff pressure which fully occludes limb arterial flow at rest) is …
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Characterization of platelet glycoprotein Ib-IX-V: von Willebrand factor interaction under shear conditions
Arterial thrombosis is one of the important pathophysiological mechanisms that lead to cardiovascular diseases. In this thesis, we have made an attempt to better characterize the kinetic and molecular mechanisms that underlie the critical first step in arterial thrombosis, namely, the interaction …
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4D flow and displacement sensitive MR imaging of upper arm arterio-venous connections for haemodialysis
… to ensure the access remains unblocked and the flow rate is normal. Phase Contrast MRA (PC-MRA) is a versatile Magnetic Resonance Imaging (MRI) modality which is capable of imaging and quantifying blood flow in vivo. It is for this reason that this imaging technique was used to image blood flow …
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Apoptosis in the equine small intestine following experimental ischemia-reperfusion injury
… apoptosis. Injury was induced using a low flow model of I-R. During celiotomy a single loop of jejunum was isolated and arterial flow decreased to 20% of baseline for one hour and complete occlusion for a second hour. Reperfusion was monitored for 3 hours. A control group (n=6) were not …
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Coronary flow mechanics: an anatomically based mathematical model of coronary blood flow coupled to cardiac contraction
Coronary blood flow through the ventricular contraction cycle has been investigated in this thesis using an anatomically accurate computational model. Using Strahler ordered morphological data and an avoidance algorithm a three dimensional finite element model has been constructed of the largest …
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An investigation of liver blood flow in systemic inflammation
… to be important in critical illness. Liver blood flow has been studied in systemic inflammation but the relative inaccessibility of the portal vein and the hepatic artery has made this a difficult task. The few studies that have been performed in critically ill patients have used the Fick …