Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"arsenic trioxide"”.
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Arsenic trioxide in ovarian cancer
Arsenic trioxide (As2O3) has shown anti-tumour activity against a variety of solid tumours in vitro. However, the mechanisms responsible for its cytotoxicity against ovarian carcinoma remain elusive. In this thesis, the molecular determinants of its effects and factors mediating its chemoresistance …
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Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma
… for patients with a disseminating disease. Arsenic trioxide (As2O3) is one of the oldest medicines used for treatment of different diseases and it is today used as first-line treatment for patients with relapsed or refractory acute promyelocytic leukemia. Here, we demonstrate that As2O3 is …
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Selective delivery of arsenic trioxide to HPV positive cervical cancer cells with targeted liposomes
… anti-HPV drug available for cancer treatment. Arsenic trioxide (ATO) has been shown to induce apoptosis in HPV-infected cervical cancer cells in vitro but its wider clinical applications have been compromised by its toxicity and poor pharmacokinetics. This research explores an optimized drug …
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A study to characterise the “arsenic rash” observed at a copper smelter in Tsumeb, Namibia
This study is located at a copper smelter. Arsenic is a component of copper bearing ore and arsenic trioxide is a by-product of copper smelting. The vapours (“off-gases”) that are released from the molten copper-bearing ore cool and condense in evaporative coolers to form arsenic-containing dust in …
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Schweinfurt Green: some experiments on the action of arsenic trioxide on copper acetate, with the view of investigating the composition of the above compound
Thesis: B.S., Massachusetts Institute of Technology, Department of Chemistry, 1881
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Studies on the behaviour of Reticulitermes santonensis (Feytaud) in laboratory colonies and its implications for some methods of termite control
… the response of colonies to nestmates carrying arsenic trioxide was investigated. It was found that living and freshly dead arsenic-carrying nestmates were treated like normal nestmates, resulting in high initial mortality. However, poisoned cadavers soon became repellant and were buried thus …
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Cytochrome C biosensor for the determination of trace level arsenic and cyanide compounds
… been developed, for the detection of selected arsenic and cyanide compounds. Boron Doped Diamond (BDD) electrode was used as a transducer, onto which cyt c was immobilised and used for direct determination of Prussian blue, potassium cyanide and arsenic trioxide by inhibition mechanism. The …
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Novel Cancer Therapeutics, the Generation of ROS, and Cell Survival
… by clinically relevant concentrations of arsenic trioxide, synergized with subnanomolar concentrations of GST-MDA-7 to inhibit the proliferation, viability, and long-term survival of RCC. We also found that MDA-7 (IL-24), when expressed via a recombinant replication defective adenovirus, …
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Some contributions to iodometric technique
… was confined to the reaction of iodine with arsenic trioxide, concerning which Kolthoff says: "Standardization against arsenious oxide has proved to be best."<sup>3</sup></p>
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Application of phosphate and surfactant-modified zeolite for remediation/attenuation of trace elements in soil and coal fly ash
… contamination sourced by coal fly ash and arsenic trioxide herbicide. Both alkaline and acidic fly ash samples were found to contain significant concentrations of environmentally available trace elements. The treatment of fly ash leachate with surfactant-modified zeolite (SMZ) decreased the …
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The acceptability and palatability of certain feeds, diluents, and poisons to pitymys, microtus, and peromyscus
… percentage killed by zinc phosphide, strychnine, arsenic trioxide, and ANTU was much less. All of these poisons, with the exception of zinc phosphide, were eaten rather readily. In most cases, however, a sub-lethal dose was acquired, after which the mice refused to eat further of the particular …
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Defining the mechanism of arsenic-induced degradation of PML
Arsenic trioxide is a clinically effective treatment for the disease acute promyelocytic leukaemia (APL) which is caused by the chromosomal translocation t(15;17) which fuses the promyelocytic leukaemia (PML) protein to the retinoic receptor alpha (RARa). The PML-RARa oncoprotein disrupts normal …
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LINEAGE TRACING REVEALS PAEP AS A CHEMOTHERAPY-INDUCED METASTATIC DRIVER AND EXPOSES METABOLIC VULNERABILITIES OF CIRCULATING TUMOR CELLS IN BREAST CANCER
… prediction that oxidative stressors (e.g., arsenic trioxide) preferentially eliminate CTCs. AC reshapes TNBC evolution by pruning diversity yet selecting a restricted set of clones with integrated chemoresistance and metastatic competence. PAEP emerges as a secreted, senescence‐linked …
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APPROACHES OF MODULATION OF THERAPEUTIC TARGETS RELEVANT TO DRUG RESISTANCE
… clone exhibited a low susceptibility to arsenic trioxide-induced apoptosis, associated with low reactive oxygen species induction and increased catalase activity. The combination of arsenic trioxide with subtoxic concentrations of ascorbic acid resulted in a sensitization to apoptotic …