Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"arrhythmogenesis"”.
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Atrial arrhythmogenesis in a murine model of mitochondrial insufficiency
Age-related atrial arrhythmias including atrial fibrillation are frequently encountered in clinical practice and are associated with significant mortality and morbidity. A putative role for chronic mitochondrial impairment in their pathogenesis was investigated using a murine model with homozygous …
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Defining a Novel Role for the E3 Ubiquitin Ligase Wwp1 in Cardiac Arrhythmogenesis
… heart pathologies that predispose to ventricular arrhythmogenesis (e.g., coronary artery disease, cardiomyopatheis, or channelopathies), therapies that prevent SCD would have a major impact in medical practice as there are few options that currently exist. In the heart, gap junctions function as …
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Mechanisms of ventricular arrhythmogenesis in the age dependent Pgc-1β -/- model of mitochondrial dysfunction.
… and ageing as independent risk factors for arrhythmogenesis beyond the risk they confer to coronary artery disease. To date, researchers have focused upon investigation of monogenic ion channel disorders as well circumscribed diseases to investigate the principles of arrhythmogenesis. This …
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Calcium Remodeling through Different Signaling Pathways in Heart Failure: Arrhythmogenesis Studies of Pyk2, Dystrophin, and β-adrenergic Receptor Signaling
<p>Heart failure is a common clinical syndrome that ensues when the heart is no longer able to generate sufficient cardiac output to meet the demands of the body. It is one of the leading causes of death worldwide but with limited and non-ideal therapies at the moment. One reason behind this may be …
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Cardiac Fibrosis and Ventricular Arrhythmogenesis: Unravelling the influence of fibrosis on electrical dysfunction in the development of heart failure
… hallmark of progression towards HF, its role in arrhythmogenesis remains an area of debate. With this in mind, the principal objectives of this study were to characterise the relationships between electrical dysfunction and multi-scale structural remodelling in the progression towards HF. To …
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The Temporal Nature of Ectopic Activity in Guinea Pig Ventricular Myocardium
… to elucidating the mechanisms that can lead to arrhythmogenesis. However, challenges remain in distinguishing between ectopic and non-ectopic beats. A new methodology was developed and validated to distinguish between beat types. Rapid pacing was used to induce both ectopic and non-ectopic …
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Arrhythmogenic mechanisms of acute cardiac infection
… myocardium, which is thought to contribute to arrhythmogenesis. The chronic phase is immune response-mediated, where the host immune system causes damage that induces gross remodeling of the heart, which can result in cardiac arrest or heart failure. Electrical impulses of the heart are …
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Gatekeeper Connexin43 Phosphorylation Events Regulate Cardiac Gap Junction Coupling During Stress
… biology will facilitate better understanding of arrhythmogenesis, and potential therapeutic strategies to restore or preserve normal electrical coupling in diseased hearts.
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Phosphorylation kinetics of cardiac gap junction regulation during stress
… for prevention of cardiac remodeling and arrhythmogenesis.
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Sodium Channel Loss of Function Sensitizes Conduction to Changes in Extracellular Sodium Concentration
… of conduction velocity is one major factor in arrhythmogenesis. By understanding the mechanisms and factors that modulate cardiac conduction velocity, we can assess and perhaps mitigate the risk of arrhythmia in patients for whom slowed conduction is a arrhythmogenic substrate. Cardiac …
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DYSREGULATION of PROTEIN QUALITY CONTROL IMPAIRS FUNCTION of PRIMARY CARDIOMYOCYTES
… in electrical conduction abnormalities and arrhythmogenesis. Therefore, understanding the underlying mechanism the quality control of mitochondria and gap junctions profoundly contributes toward understating the genesis of cardiomyopathy. Furthermore, cardiovascular problems in HIV (Human …
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Investigating the coordination of cardiac conduction and repolarization in ventricular myocardium
… repolarization are established prerequisites for arrhythmogenesis. The following dissertation investigates how reducing either ephaptic (EpC) or gap junctional (GJ) coupling between cardiomyocytes can modulate cardiac conduction, repolarization, or the relationship between these two phenomena. Our …
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Contribution of the Purkinje System in Initiation and Maintenance of Arrhythmias
… system and its interaction with ventricles in arrhythmogenesis and maintenance. Firstly, simulations were performed on a model of rabbit ventricles to explore Purkinje system contributions during ventricular fibrillation. A fractal method for growing the Purkinje system was implemented to allow …
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The Binding Properties and Functional Consequences of Ryr2-Cam Interaction
… knowledge of molecular mechanisms that underlie arrhythmogenesis and HF. Importantly, it pinpointed a potential molecular target responsible for Ca triggered arrhythmias and may translate into the development of novel therapeutic strategies</p>
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Model Based Analysis of QT Variability Independent of Heart Rate and Respiration
… the repolarisation process also contributes to arrhythmogenesis and increased risk of SCD. Improving the ability to sense instability in the repolarisation process and quantifying neural contribution to arrhythmia can improve the ability to predict the onset of ventricular arrhythmias and …