Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 57 for “"arrestin"”.
-
Nicotine Sensitization in β-Arrestin 2 Knockout Adolescent Mice.
<p>ß arrestin-2 is a protein involved in signaling of D2 receptors and plays a mediating role in sensitization to psychostimulants and the opiate morphine. In this study, 3-4 week old BA-2 KO and wild type C57/B6 mice received nicotine tartarate (s.c, 0.5 mg/kg free base) for 7 or 14 consecutive …
-
Phosphorylation Bar Codes Induce Distinct Conformations and Functionalities of beta-Arrestin
… kinases (GRKs) and subsequently recruit beta-arrestins. beta-arrestins are multifunctional adaptor proteins which not only desensitize G-protein signals, but also facilitate receptor internalization and mediate numerous signaling pathways on their own. As beta-arrestins universally interact …
-
Alternative rownstream roles for Ste2p and an α-arrestin in sacccharomyces cerevisiae mating
… model system in GPCR research. While the arrestin- mediated biased signaling mechanism of mammalian GPCR has not been discovered for the pheromone receptors, a recent demonstration of α-arrestins being involved in the internalization of the pheromone GPCR, Ste2p was reported. The present …
-
β-arrestin interacting domains on the type II gonadotropin-releasing hormone (GnRH) receptor
Over-expression of β-arrestin 1 in COS-l cells revealed that the mammalian type GnRH receptor can internalise in a β-arrestin dependent manner whereas the internalisation of the mammalian type I GnRH receptor is β-arrestin independent. investigate which domains on the mammalian type II GnRH …
-
The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR
… 2006 Pharmaceutical Sciences THE ROLE OF â–ARRESTIN IN AGONIST-INDUCED DOWN-REGULATION OF THE M1 mAChR Chair: Darrell A. Jackson G protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors. They mediate diverse cell signaling pathways and therefore are currently …
-
The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR
… 2006 Pharmaceutical Sciences THE ROLE OF â–ARRESTIN IN AGONIST-INDUCED DOWN-REGULATION OF THE M1 mAChR Chair: Darrell A. Jackson G protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors. They mediate diverse cell signaling pathways and therefore are currently …
-
Activation of the Transient Receptor Potential Vanilloid-1 (TRPV1) channel mediates Extracellular Signal Regulated Kinase (ERK) phosphorylation via Beta-arrestin-2 signaling
… Recent work highlighted a possible role for β-arrestin-2, a scaffolding protein that mediates G-protein coupled receptor desensitization, in channel regulation. Interestingly, β-arrestin-2 also acts as a signaling scaffold for the MAPK (ERK1/2) pathway which was described as an important …
-
Development of a Microplate-Based Calcium Assay for Studying Desensitization of the P2Y2 Nucleotide Receptor
… receptor kinase (GRK) family and the β-arrestins. As GRK2 and β-arrestin-1 have been demonstrated to mediate P2Y2R desensitization in rat arterial smooth muscle cells, it was hypothesized that the human homologs would mediate P2Y2R desensitization in human 1321N1 cells. To test this …
-
Ligand induzierte Phosphorylierung des Chemokin Rezeptors CCR5: strukturelle Analyse und Funktion
… Es konnte gezeigt werden, daß sowohl für die β-Arrestin-Bindung als auch für die schnelle Rezeptorinternalisierung wenigstens zwei C-terminale Serin-Phosphorylierungsstellen vorhanden sein müssen, wobei die exakte Position dieser zwei Serine unerheblich ist. Für die Rezeptordesensibilisierung …
-
Functionally selective receptor signaling and endocytosis by dopamine D1 receptor agonists
… agonists increase cAMP production and recruit β-arrestin to the plasma membrane, which may lead to receptor desensitization and/or induce D1R endocytosis. In addition, the D1R is essential for voluntary movement, cognition and reward processes. As such, the D1R is a validated drug target for a …
-
Molecular Regulation of Opioid Receptor Signaling
… G protein-coupled receptor kinase (GRK) and arrestin. Therefore, a partial KOR agonist that does not efficiently activate arrestin-dependent signaling may produce analgesia without dysphoria. No selective KOR partial agonists are currently available, and preclinical assessment is complicated …
-
Internalisation of the type II gonadotropin-releasing hormone receptor of marmoset monkey
… receptor kinases (GRKs), dynamin-1 and β-arrestin 1 and 2 with the type II GnRH receptor. The results show that internatisation of the receptor requires GRK 2 and dynamin but does not require β-arrestin 1 and 2. Furthermore, inhibitors to both the caveolae pathway as well as the clathrin …
-
Studies on Cellular Nutrient Responses and Protein Degradation
… mechanism induced by perceived starvation. The arrestin proteins can bind GPCRs to mediate their internalization or to facilitate downstream signaling. I tested the hypothesis that β-arrestin 2 might participate in regulation of mTOR activity and autophagy by amino acids. siRNA-mediated …
-
Molecular Mechanisms Regulating Chemokine Receptor CXCR4 Signaling and Trafficking
… laboratory, it was shown that adaptor protein arrestin-2 interacts with AIP4 to regulate endosomal sorting of CXCR4 into the degradative pathway. However, the precise mechanism by which arrestin-2 performs this function remains unknown.</p> <p>We set out to determine how arrestin-2 integrates …
-
Untersuchung des Recyclings Kaede-fusionierter Corticotropin-Releasing-Factor Rezeptoren Typ 1
… Clathrin-vermittelt in Anwesenheit von β-Arrestin. Je nach Stabilität der β Arrestin-Interaktion unterscheidet man zwei Klassen von Rezeptoren: Klasse A-Rezeptoren interagieren transient mit β Arrestin und können recyceln. Im Gegensatz dazu gehen Klasse B-Rezeptoren eine stabile …
-
Ligand Bias by the Endogenous Agonists of CCR7
… the G-protein coupled Receptor Kinase (GRK)/ b-arrestin system. CCL19 and CCL21 are endogenous agonists for the chemokine receptor CCR7. They are known to be equipotent in promoting Gi/o mediated calcium mobilization, chemotaxis and inhibition of adenylyl cyclase activity. Here we test the …
-
Biased Constitutive Activity in the Uveal Melanoma Oncogene CYSLTR2 is Unique in CYSLTR2 Germline and Pan-Cancer Human Variome
… However, CysLTR2-L129Q only poorly recruits β-arrestin as shown by a bioluminescence resonance energy transfer 2 (BRET2) based β-arrestin recruitment assay. Using a modified Slack-Hall operational model, we quantified the constitutive activity for both pathways and conclude that CysLTR2-L129Q …
-
MOLECULAR MECHANISMS UNDERLYING CLINICAL BEHAVIOR OF NEUROENDOCRINE TUMORS: STUDY OF NEW POSSIBLE BIOMARKERS PREDICTABLE OF PHARMACOLOGICAL RESISTANCE AND TARGETS
… more specifically focusing on G-proteins and β-arrestins DRD2-mediated signaling pathways in PitNETs and on somatostatin/cortistatin system in novel PanNENs cell models. Briefly, β-arrestin 2 has been highlighted as novel potential biomarker of pharmacological responsiveness to DAs, and that …
-
Biochemical investigation of phosphodiesterase type IV post-translational modification, cellular localisation and interaction with associated binding proteins
… of PDE4 isoforms with binding partners like β-Arrestin, AKAP18 δ and UBC9. Rolipram is an archetypal PDE4 specific inhibitor. In this study it is shown that in cells expressing a GFP tagged form of PDE4A4 undergoes redistribution into accretion foci upon chronic treatment with rolipram. Data …
Page 1 of 3