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Showing 1 to 17 of 17 for “"array CGH"”.

  1. Hidden Markov Model inference copy number change in array-CGH data

    Zhang, YunyuMassachusetts Institute of Technology2005

    … novel oncogenes and tumor suppressors. Recently, array based competitive genomic hybridization (array-CGH) has become available as a powerful approach for genome-wide detection of DNA copy number changes. Array-CGH assesses DNA copy number in tumor samples through competitive hybridization on …

    mit Repository record

  2. Comparative analysis of algorithms for identifying copy number variation in array CGH data

    Kamat, Mihir AnantUniversity of Central Lancashire2009

    … for identifying copy number variation in array CGH data. Circular Binary segmentation (CBS), CGH segmentation, Price —Smith—Waterman algorithm (the three algorithms are a part of ADaCGH tool) and Cluster Along Chromosome (CLAC) which is not publicly available were studied and used for the …

    cent-lancashire Repository record

  3. Molekular-zytogenetische Untersuchungen und Expressionsanalysen des Multiplen Myeloms

    Grandy, IsabellTechnische Universität Dresden

    Durch die Kombination von SKY-, Array-CGH-, und Expressionsnanalysen wurden ausgewählte MM-Zelllinien auf Aberrationen hin untersucht und diese genauer analysiert. 32 Myelom-Patienten wurden mittels Array-CGH-Analyse untersucht und aufgrund ihrer Aberrationen und der klinischen Daten durch eine …

    qucosa-diss

  4. High resolution DNA copy number analysis of constitutional chromosomal aberrations in human genomic disorders

    Menten, Björn2007

    … for detection of CNVs. This technique, termed array comparative genomic hybridization (array CGH), allows the genome wide screening for submicroscopic aberrations in one single experiment. Array CGH uses reporter DNA molecules more or less evenly spread throughout the entire genome which are …

    ghent Repository record

  5. The pathogenesis of classical Hodgkin lymphoma : investigation of possible viral pathogens and recurrent chromosomal imbalances

    Wilson, Katherine SarahUniversity of Glasgow2008

    … of molecular cytogenetic techniques (i.e. array-comparative genomic hybridisation (CGH) are overcoming these difficulties. To investigate a potential candidate virus, DNA samples from cHL biopsies were screened for the measles virus (MV) and polyomaviruses (PyV), using immunohistochemistry …

    glasgow Repository record

  6. Developing and Optimizing Conditions for Single Cell Genetic Analysis

    Gitlin, Susan Adele2019

    … to generate sufficient DNA for eventual use in array comparative genomic hybridization (CGH) to determine chromosome complement. Sporadic MDA results occurred at the single cell level; larger cell quantities consistently amplified. MDA can generate sufficient quantities of DNA for array CGH. …

    odu Repository record

  7. Trisomies in Hematologic Malignancies

    Paulsson, KajsaSection of Clinical Genetics, Institution of Laboratory Medicine, Lund University Hospital2005

    … (FISH) analysis and high-resolution genome-wide array-based comparative genome hybridization (array CGH), respectively, in order to determine whether this chromosome abnormality was truly isolated or if there were additional, cytogenetically cryptic, anomalies present. Whereas multicolor-FISH, …

    lund Repository record

  8. Genetic changes in the development of multiple myeloma

    Chiecchio, LauraUniversity of Southampton2010

    … progression of MGUS and SMM. High resolution array CGH showed an increasing level of genomic complexity from MGUS (n=25) to SMM (n=15) to MM (n=47) to PCL (n=11). In MGUS, the number of copy number changes per case was highly associated with progression (P=0.003). The simplest profiles …

    soton Repository record

  9. Parents' experiences of genetic diagnosis in their child: an exploratory study

    Bryson, LisaUniversity of Dundee2014

    … such as Next Generation Sequencing and array CGH. Very little is known about the impact of such diagnoses on parents, and the parents’ need for support following<br/>testing. We, therefore, used a qualitative methodology to explore the effect of diagnosis on parents and to identify areas …

    dundee Repository record

  10. Genomic characterization of ETV6/RUNX1-positive acute lymphoblastic leukemia

    Lilljebjörn, HenrikLund University2011

    … ALLs were characterized using array CGH. This revealed that gain of Xq material, present in six cases, was the most common copy number aberration (CNA). A large number of genes was present in the commonly gained region but the high and specific expression of SPANXB identified …

    lund Repository record

  11. The structure and evolution of breast cancer genomes

    Newman, ScottUniversity of Cambridge2011

    … lines, HCC1187, VP229 and VP267 using data from array painting, SNP6 array CGH, molecular cytogenetics and massively parallel paired end sequencing. I then used these structural genomic maps to predict fusion transcripts and demonstrated expression of five fusion transcripts in HCC1187, three in …

    cambridge Repository record

  12. Functional Analysis of the F-box protein Fbxl17

    Mason, Bethany JaneUniversity of Cambridge2020

    … the METABRIC dataset, consisting of segmented array-CGH copy number data, and paired-end whole-genome DNA and RNA sequencing data from primary breast tumours, we found that the F-box protein encoded by FBXL17 is frequently rearranged in breast cancer. F-box proteins are the …

    cambridge Repository record

  13. Alteración del cromosoma 14 en meningiomas y su relación con las características clínico-biológicas de la enfermedad

    Espinosa Oquillas, Ana Belén2008

    salamanca Repository record

  14. A clinicopathological and molecular genetic analysis of low-grade glioma in adults

    Singh, Anushree2014

    … methylation analysis, copy number analysis using array comparative genomic hybridisation and identification of differentially expressed miRNAs using miRNA microarray analysis. IDH1 mutation was present at a frequency of 71% in low grade glioma and was identified as an independent marker for …

    wlv Repository record

  15. The Role of Acidic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor 4 In High Grade Serous Carcinoma

    Zaid, Tarrik2012

    … correlation studies on data generated from array CGH and transcriptome profiling analyses on 51 microdissected tumor samples were used to identify genes located on chromosome 5q31-35.3 that showed significant correlation between DNA and mRNA copy numbers<strong>. </strong>Significant …

    uthsc Repository record

  16. Estudio de rendimiento diagnóstico y análisis de resultados de la secuenciación del exoma clínico en pacientes con discapacidad intelectual.

    Ballesta Martínez, María Juliana2020

    … causa que explicara su DI, así como estudio de array-CGH y estudio molecular de X frágil con resultado normal. Se recogieron las variables de interés mediante revisión de las historias clínicas y se realizó un análisis estadístico buscando asociación con la obtención de un diagnóstico molecular …

    murcia-diss Repository record

  17. Genetic and epigenetic characterization of pediatric high hyperdiploid acute lymphoblastic leukemia

    Davidsson, JosefLund University, Faculty of Medicine2009

    … cluster and principal component analyses of BAC array chromosome-wide methylome profiles accurately subgrouped the t(12;21) and HeH ALL subtypes, demonstrating that they are characterized by subtype specific methylomes. Analysis of promoter-specific CpG islands demonstrated that several B-cell- …

    lund Repository record