Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"aromatic stacking"”.
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Part I. A Stacked Intercalator Approach to Selectively Target Mismatches Within CTG and CUG Trinucleotide Repeats. Part II. Aromatic Stacking of Naphthoyl Modified Cytosines Within PNA·DNA Duplexes
… to determine the stabilization due to added stacking between the naphthoyl substituents aligned within the major groove. PNA·DNA duplex stabilization was observed when three naphthoyl substitutions were aligned when compared to the same PNA·DNA duplex with separated naphthoyl …
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Solvophobically-Driven Folding of Non-Biological Oligomers and the Solid Phase Synthesis of Phenylacetylene Oligomers
… reveal dramatic chain-length-dependent aromatic chemical shifting in CD$\sb3$CN, indicative of aromatic stacking and helical structure. In addition. when chain length reaches 12 monomer units, oligomers begin to strongly aggregate which may be a result of helical oligomers associating …
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Modulation of the Aromatic-Aromatic Stacked Organizations of Phenylene Ethynylene Macrocycles and Oligomers Through Structure Modification
… ethynylene architectures can influence their aromatic-aromatic stacking propensities, and that the nature of these architectures can be modulated by the design of appropriate hetero-sequences.
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A Thermostable Cytochrome P450 From Sulfolobus Solfataricus
… and tertiary structural interactions, such as aromatic stacking, increased salt link networks, short strong hydrogen bonds, and increased secondary structure due to shorter loops. These insights into local and globular protein stability should aid in the optimization of proteins for drug design …
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Studying the properties of conjugated donor acceptor complexes with naphthaleneimide acceptors and dialkoxybenzene donors linked by a triple bond
The self-assembly of aromatic electron donor and acceptor units into alternating stacks has been studied extensively by the Iverson research group as well as others. As an extension of previous research in this area, novel conjugated donor/acceptor molecules made from …
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Protein-ligand interaction studies and identification of new drug-like hits as cannabinoid receptor modulators
… and CB2 receptors that are engaged in H-bonding, aromatic stacking, and hydrophobic interactions with the ligand. Chapter 3 focuses on the identification of new CB1 inverse agonists using protein structure-based virtual screening. These compounds exhibited nanomolar to micromolar binding …
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Structure determination of a yeast ribosomal protein L30 and pre-mRNA binding site complex by NMR spectroscopy
… into two sections. One region consists of mostly aromatic stacking and hydrophobic contacts from Leu25, Phe85 and Val87 of the protein to G56 of the RNA. The other region consists of mostly specific contacts, which include recognition of A57 by Asn 48, and G58 by Arg 52. The L30 protein- RNA …
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Computational and Pharmacological Characterization of HDAC6 Inhibition and Function
… are uncovered in both domains. In addition, π-π aromatic stacking interactions are also observed between W208 (CD1) or F680 (CD2) and the terminal CAP segment of the inhibitors. Potential binding cavities have been mapped that will, hopefully, allow for further inhibition of HDAC6 outside of the …
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Self-assembled Peptide Hydrogels for Therapeutic H2S Delivery
… to peptide sequences to form H2S-releasing aromatic peptide amphiphile (APA) hydrogels. APAs formed nanofibers, which were stabilized by beta-sheets and aromatic stacking. The self-assembled structures were affected by the substituents on the aromatic rings of SATOs, leading to the formation …
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Studies of the Unusually Extended DNA Inside the Pf1 Bacteriophage by Solid-State NMR and Computational Methods
… lack of base pairing, and the presence of aromatic stacking. Specific protein-DNA contacts consistent with those predicted by models are also observed. Fragment-based ab initio chemical shift prediction methods are employed in efforts to derive additional information from the experimental …
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Understanding the Effects of Higher-Order Assembly on the Structure of Sulfite Reductase
… the eight copies of SiRFP. These residues show aromatic stacking (Y39, F40) and salt bridge interactions (Q22, Q47) between the helices and thus form a strong octameric bundle. Mutating these four amino acids results in a tetrameric assembly of SiRFP. The ultra stable properties of SiRFP's …
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PRE-NUCLEATION IN MOLECULAR LIQUIDS: A MOLECULAR DYNAMICS PERSPECTIVE
… infine, esplorare il ruolo delle interazioni di stacking aromatico nei fenomeni di pre-nucleazione. L’acido benzoico è stato selezionato come composto modello data la sua limitata flessibilità molecolare, il numero di atomi ridotto e la sua capacità di partecipare a diverse interazioni …