Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"aripiprazole"”.
-
EFFECTS OF REPEATED ARIPIPRAZOLE TREATMENT ON THE cAMP AND AKT PATHWAYS IN THE DORSAL STRIATUM OF PREADOLESCENT AND ADULT RATS
… that can cause severe extrapyramidal effects. Aripiprazole, a dopamine and serotonin partial agonist, has fewer side effects, making it tolerable for adults and children. Extrapyramidal effects (e.g. Parkinsonism, dystonia, and akathisia) are among the most problematic side effects produced by …
-
Antipsychotic drugs for the treatment of acute schizophrenia after the first episode
… was better individual patients’ response to aripiprazole vs. ziprasidone (CDSS p=0.04), aripiprazole vs. quetiapine (BPRS p=0.02, YMRS p=0.001) and ziprasidone vs. quetiapine (CGI p=0.02, CDSS p=0.02) in the study sample. In the short term APDs use, the difference between aripiprazole and …
-
A Dual Approach of Salt Formation and Amorphous Solid Dispersion for Improved Oral Drug Delivery
… belonging to BCS class II drugs, clofazimine, aripiprazole, and haloperidol, were selected as model drugs. Ten salts of each drug were prepared with counterions with ΔpKa> 3 using a rotary evaporator and characterized for thermal analysis, structural analysis, and equilibrium drug solubility. …
-
Using functional analysis methodology to evaluate neuroleptic medication effects on positively and negatively reinforced severe problem behavior.
… prescribed atypical neuroleptic medication (aripiprazole) was evaluated using a randomized AB multiple baseline, double-blind, placebo controlled design in the treatment of severe problem behavior (SPB) in children with intellectual and developmental disabilities. A pre-treatment screening …
-
Variability in Pricing of Generic Antipsychotic Medications Used in the Treatment of Schizophrenia at Community Pharmacies in the Kansas City Metropolitan Area
… olanzapine, quetiapine, ziprasidone, and aripiprazole) recommended for first line therapy in the treatment for schizophrenia is lacking. Pharmacy-level variability in retail cash pricing for five generically available second-generation and one first-generation antipsychotic medications at …
-
Examining How Non-Antifungal Medications Impact Host-Fungal Interactions
… One medication of interest, the anti-psychotic aripiprazole, was consistently identified as an antagonist for all screens tested, and was found to be Tac1p-dependent for azole tolerance, a zinc cluster transcription factor commonly found with gain-of-function mutations in azole resistant …
-
FUNCTIONAL SELECTIVITY DOWNSTREAM OF Gαi/o-COUPLED RECEPTORS
… novel, “third generation” antipsychotic drug, aripiprazole is also used to treat schizophrenia, with the remarkable advantage that its tendency to cause extrapyramidal symptoms is minimal. In this work we studied the molecular pharmacology of aripiprazole and showed that the compound displays …
-
The Effect of Typical and Atypical Antipsychotics on the MK-801 Induced Deficit in Behavioural Inhibition
… MK-801 and did not alter pERK1/2 labeling. Aripiprazole, given at 1 mg/kg, decreased MK-801 induced bar pressing to that of the saline control group but there were no differences in pERK1/2 labeling in the IL. The data suggest that MK-801 does induce deficits in behavior inhibition that may …
-
The Discriminative Stimulus Properties of the Atypical Antipsychotic Clozapine in C57BL/6 Mice
… melperone fully substituted for clozapine but aripiprazole did not. The typical antipsychotics fluphenazine and perphenazine failed to fully substitute for clozapine but chlorpromazine and thioridazine fully substituted for clozapine. This model does not differentiate between atypical and …
-
Innovative analytical methods for Central Nervous System Drug analysis in biological fluids
… (sertraline and duloxetine), antipsychotics (aripiprazole), antiepileptics (vigabatrin and topiramate) and antiparkinsons (pramipexole). Innovative methods based on liquid chromatography or capillary electrophoresis coupled to diode-array or laser-induced fluorescence detectors have been …
-
Characterising the functional homology of central nervous system drug targets in larval zebrafish (Danio rerio)
… trazodone), and three antipsychotics (aripiprazole, clozapine, risperidone). Chapter 1 reviews the occurrence, mechanisms of action, and environmental relevance of CNS-active pharmaceuticals, identifying key knowledge gaps in linking molecular conservation to ecological outcomes. Major …
-
Investigation of the Effects of Antipsychotics on CNS Insulin-mediated Brain Glucose Uptake using 2DG Autoradiography
… APs (haloperidol, raclopride, risperidone, and aripiprazole) with varying receptor affinities. We determined that all APs, regardless of class, also induced central insulin resistance in regions responsible for reward processing, motivation, metabolism, as well as cognition. Taken together, our …
-
Multiple Memory Systems in People With Schizophrenia: Possible Effect of Atypical Anti-Psychotic Medications
… hypothesized that performance of patients taking aripiprazole would be comparable to those taking risperidone, or an FGA; however, we were unable to recruit a sufficient amount of participants to test this hypothesis. Patients with schizophrenia, a mental disorder characterized by a breakdown in …
-
Advancing Precision Medicine in Psychiatry: Genetic Insights into Antidepressant Treatment Outcomes
… improvement from baseline were augmented with aripiprazole (ARI) for an additional 8 weeks, while responders continued ESC monotherapy until trial end or Week 16 (Phase II). The meta-analysis showed a significant association between ABCB1 rs1128503 variant and antidepressant response, with …
-
Integrative multiomic insights into Alzheimer’s disease pathology
… In Chapter 7, I showed that the antipsychotic aripiprazole, which is taken by AD patients to treat psychotic symptoms, is neurotoxic through inhibiting mitochondrial complex I. Taken together, my work integrates multiomic data from animal models and human AD patients to gain insights into …
-
METABOLIC ADVERSE EFFECTS INDUCED BY SECOND GENERATION ANTIPSYCHOTIC DRUGS IN PEDIATRIC PATIENTS: PHARMACOGENETIC PROFILING AND MECHANISTIC ANALYSIS OF GENETIC VARIANTS EFFECT IN VITRO MODELS
… who are prescribed SGAs (risperidone and aripiprazole), we have assessed the association of pharmacodynamics genetic variants with the occurrence of changes in body mass index (BMI) Zscore. This allows us to evaluate if the presence of specific variant alleles increases or decreases the …
-
Understanding the impacts of antipsychotic pharmaceuticals on behaviour in fish
… these atypicals, quetiapine, risperidone and aripiprazole produced the most extensive changes across key regions of interest. These agents were later assessed on the attraction-aversion axis, finding reliable changes to feeding behaviour, including a reduction in feeding efficiency for …