Global ETD Search
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Showing 1 to 6 of 6 for “"arenophile"”.
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Arenophile-mediated dearomative functionalization of unactivated arenes
… dearomative methods are reported using an “arenophile” called MTAD. Arene-arenophile cycloadducts are formed by irradiation of mixtures of unactivated arenes and MTAD at cryogenic temperatures with visible light. These cycloadducts are subsequently used as substrates in metal-catalyzed …
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Dearomative functionalization of simple arenes: Reduction and palladium-catalyzed syn-1,4-aminofunctionalizations
… of a dearomative strategy that employs an arenophile, such as N-methyl-1,2,4-triazoline-3,5-dione (MTAD), which undergo a visible- light-mediated formal [4+2] para-cycloaddition with simple arenes. The resulting dearomatized arene-arenophile cycloadduct possesses multiple functional …
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Unique applications of dearomative strategies: I) arene-oxides/oxepines through a dearomative epoxidation of non-activated arenes Ii) arenophile-mediated dearomatization of pyridines Iii) solution-state electrochemical dearomatization of polystyrene
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Dearomative reduction of arenes through the use of arenophiles & studies towards the synthesis of cardiotonic steroids calotropin and calactin
… reduction of arenes through the use of N,N-arenophile, MTAD, was developed. Cheap feedstock arenes undergo photocycloaddition with MTAD, and the cycloadduct can be treated further to furnish novel 1,3-cyclohexadienes or 1,4-diamino-2- cyclohexenes. The utility of this method is shown in the …
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Dearomative hydroboration-enabled synthesis of idarubicinone and synthesis of minor cannabinoids and their metabolites
Anthracyclines are archetypal representatives of tetracyclic type II polyketide natural products that are widely used in cancer chemotherapy. Although syntheses of this class of compounds have been extensively explored, all known approaches are based on annulations, relying on the union of properly …
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Progress towards the enantioselective total synthesis of trichodermamide B
Trichodermamide B is an unusual modified dipeptide natural product, with very promising anticancer activities. While the biosynthesis of this molecule is unknown, it is proposed herein that it is formed in vivo through direct oxidation of phenylalanine to the arene oxide or arene dioxide …