Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"arenavirus"”.
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Arenavirus Attenuation Mechanisms
… meaning ‘sand’. When scientists first looked at arenavirus virions by transmission electron microscopy, they saw pleomorphic particles that had a sandy appearance. This sandy appearance was due to host ribosomes being incorporated into the virions. Numerous studies were performed in the 1970s …
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Biogenesis, Assembly and Intracellular Trafficking of Junin Arenavirus Envelope Glycoprotein Complex
An unusual feature in the arenavirus envelope glycoprotein complex (GP-C) is the presence of a myristoylated stable signal peptide (SSP) in addition to the receptor binding subunit G1 and the transmembrane fusion subunit G2. Genetic studies were employed to understand the structure-function of the …
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Biogenesis, Assembly and Intracellular Trafficking of Junin Arenavirus Envelope Glycoprotein Complex
An unusual feature in the arenavirus envelope glycoprotein complex (GP-C) is the presence of a myristoylated stable signal peptide (SSP) in addition to the receptor binding subunit G1 and the transmembrane fusion subunit G2. Genetic studies were employed to understand the structure-function of the …
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A Recombinant Vesicular Stomatitis Virus Expressing the Junin Virus Glycoprotein for Arenavirus Countermeasure Development
Arenaviruses are pathogens of biodefense importance due to their potential for aerosol transmission and mortality rates reaching 30%. Here, we evaluated the use of a recombinant vesicular stomatitis virus expressing the Junin virus glycoprotein (rVSVΔG-JUNVGP) for the development of countermeasures …
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Cytokine patterns in a comparative model of arenavirus infection: Implications for virulence and control of viral replication
Guinea pig infection with the arenavirus Pichinde provides an animal model for human Lassa fever, a disease that affects 300,000 to 500,000 people a year in western Africa. Low passage Pichinde virus (P2) induces a mild disease with low viremia, while high passage Pichinde (P18) induces a severe …
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Mechanisms of attenuation of the live Junin virus vaccine strain, Candid #1
Millions of individuals are at risk of arenavirus infection worldwide, with untreated infections often resulting in potentially lethal disease. Junin virus (JUNV), the causative agent of Argentine hemorrhagic fever (AHF), is currently the only pathogenic arenavirus for which a vaccine is currently …
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Genetic diversity and taxonomical relationships among the tacaribe serocomplex viruses (family arenaviridae)
… and the genomes of the North American arenaviruses are not a product of homologous genetic recombination between ancestors of the present-day South American arenaviruses. Study 2 --The nucleotide sequences of the small genomic segments of 12 strains of Junin virus, 7 strains of Machupo …
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Molecular characterization of rodent- and-shrew-borne viruses and the prevalence and intensity of infestation of small mammal fleas, in Namibia
… molecularly characterize novel Hantaviruses and Arenaviruses and to determine the prevalence and intensity of fleas on small mammals in selected areas of Namibia. Small mammals were trapped from six different regions and screened for both Hantavirus and Arenavirus. The regions are, namely, …
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ANIMAL MODELS FOR BEHAVIORAL CHANGES OR HEARING LOSS UPON ACUTE VIRUS INFECTIONS
… to study as models of neurological sequelae; arenaviruses and alphaviruses. Both of these viruses are important human pathogens and the cause of the long-term neurological damage, the related pathology and the mechanisms associated with sequelae have not been identified. Sensorineural hearing …
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Genetic Determinants of Junin Virus Attenuation
The New World arenavirus Junin (JUNV) is the causative agent of the Argentine hemorrhagic fever (AHF), a deadly disease endemic to central regions of Argentina. The live-attenuated Candid #1 strain of JUNV is currently used to vaccinate human population at risk. However, the mechanism of …
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Engineering the Nicotiana benthamiana secretory pathway for the production of Lujo virus vaccines and diagnostic tools
… viral outbreaks. Lujo virus, an emerging arenavirus responsible for causing a devastating haemorrhagic fever with an 80% mortality rate, currently has no vaccines or diagnostic tools available. In this study we developed a production pipeline in HEK293T cells and N. benthamiana for the …
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The development of a reverse genetics system for Machupo virus
The etiologic agent of Bolivian hemorrhagic fever (BHF), Machupo virus (MACV), is a highly lethal viral pathogen with no approved vaccine or therapeutic to limit infection or outbreaks. Following implementation of rodent population controls after the initial outbreak, no cases of BHF were reported …
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Investigations into endothelial cell permeability and adherens junction disruption induced by Junín virus infection.
Junín virus is found in the fertile Pampas of Argentina and is maintained in nature by the rodent host, Calomys musculinus. Junín is the causative agent of Argentine hemorrhagic fever (AHF) characterized by vascular dysfunction and fluid distribution abnormalities. Clinical, as well as experimental …
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Pichinde virus infection of outbred Hartley guinea pigs and mice as small animal models of human Lassa fever
Arenaviruses are viruses that can cause severe and deadly hemorrhagic fever infections in Africa and South America, including Lassa virus that causes Lassa fever in several countries in west Africa. There are currently no vaccines and very limited therapeutics available for Lassa fever. There are …
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Arenaviruses: the Role of Antigen Presenting Cells (APC) in Persistence and Immunopathology
Viruses are major contributors to global health crises. Many of the disease pandemics the world has experienced were caused by viruses from smallpox to Spanish flu, Ebola (Public health emergency of international concern), SARS, West Nile, Zika and currently SARS-CoV-2 the aetiology of COVID19. At …
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The introduction of incompatibility between Junin virus Z protein and other viral proteins results in impaired replication and attenuation
The genus Mammarenavirus with the family Arenaviridae contains many species that are pathogenic in human hosts. Among these, Junin virus (JUNV) is a New World mammarenavirus that is the causative agent of Argentine hemorrhagic fever (AHF). AHF resulted in 15-20% case fatality during epidemics until …