Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"arcuate nucleus (ARC)"”.
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Effects of exogenous and endogenous factors on appetite regulation in broiler chicks and Japanese quail
… fewer times than control birds. Within the arcuate nucleus (ARC) there was an increase in c-Fos immunoreactivity, indicating neuronal activation, in FA-treated chicks. Within the hypothalamus, there was a decrease in mRNA abundance of galanin, ghrelin, melanocortin receptor 3, and …
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Role of gamma-aminobutyric acid (GABA) in hypothalamic nuclear development
… of three of these cell groups, the ventromedial nucleus (VMN), the paraventricular nucleus (PVN), and the arcuate nucleus (ARC). The VMN and PVN have a unique pattern of GABA expression in elements surrounding the nuclei, with a void of GABA within the region of the developing nuclei. The ARC, on …
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Oligodendrocytes of the adult median eminence
… remodelling of the ME, resulting in increased ME-arcuate nucleus (ARC) barrier permeability. Exploring potential mechanisms regulating OL lineage plasticity revealed that myelin debris generated during myelin turnover recruits immune cells to the ME, which are required for ongoing OL plasticity …
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Neuronal cicuits and reinforcement mechanisms underlying feeding behaviour
… in order to maintain homeostasis. Current research in the control of food consumption stresses the importance of identifying and establishing the specific roles of homeostatic neurons, which sense the body’s energetic state and elicit complex and flexible food seeking behaviours. Recent …
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Hypothalamic Regulation of Food Intake in Obese and Anorexic Avian Models
… the lateral hypothalamus, paraventricular nucleus (PVN), ventromedial hypothalamus, dorsomedial nucleus, and arcuate nucleus (ARC). Total RNA was isolated, reverse transcribed, and real time PCR performed. Hypothalamic expression of anorexigenic factors was greater in LWS than HWS, those …
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Transcriptomic Profiling of Hypothalamic Kiss1 Neurons
… regulation of gonadotropin secretion: the arcuate nucleus (ARC) and the anteroventral periventricular nucleus (AVPV). The two populations play distinct physiological roles in the HPG axis. Arcuate Kiss1 neurons have been implicated in the integration of various endogenous and environmental …
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Anorexia nervosa: investigation of markers of neuroinflammation, oxidative stress and synaptic plasticity using the activity-based anorexia rat model.
… in AN, and results from preclinical research are few and largely inconsistent. In the first part of the thesis, we address this issue by measuring mRNA levels of several pro-inflammatory markers (TNF-α, IL-6, IL-1β and NLRP3) and molecules involved in oxidative stress (CAT, MT1-α, GPX1, …
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Intrinsic Neuronal Plasticity of Kiss1 Neurons in Mice around Puberty
… to a fertile state. Mature Kiss1 neurons in the arcuate nucleus (ARC) and anteroventral periventricular nucleus (AVPV) project to GnRH neurons to induce GnRH pulses and surges, respectively. This thesis aimed to test the hypothesis that Kiss1 neurons in the hypothalamus exhibit neuronal …
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The Role of Neurokinin B in the Regulation of the Preovulatory LH Surge in Ewes
… been identified in the hypothalamus: one in the arcuate nucleus (ARC) and the other in the preoptic area (POA). Furthermore, ARC kisspeptin neurons have been found to colocalize two other neuropeptides as well: NKB and dynorphin A (DYN). Thus, these neurons were assigned the acronym KNDy neurons. …
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The role of notch signaling in the development of the hypothalamic-pituitary axis and arcuate nucleus
… neurons from the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON). As the pituitary develops, signals from the hypothalamus are necessary for pituitary induction and expansion. Little is known about the control of cues that regulate early embryonic signaling between the …
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Mechanisms of hypothalamic regulation of food intake in birds
… setting. The objective of this dissertation research was to determine the hypothalamic mechanisms underlying appetite regulation in birds. In Experiment 1, the Virginia lines of chickens were used to elucidate the mechanisms underlying stress-induced anorexia. These chickens have been selected …
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A neural and behavioural investigation of aberrant feeding in animal models of autism spectrum disorder
… genetics and environment. Thus far, ASD research has focused predominantly on abnormal social communication, anxiety, and cognitive impairments. It omits, however, dysregulated food intake, which is the symptom present in over 60% of ASD individuals. Data suggest that feeding abnormalities …
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Uncovering the role of notch signaling in development of hypothalamic nuclei in vivo and using in vitro microenvironments
… in two nuclei: the anteroventral periventricular nucleus (AVPV) and the arcuate nucleus (ARC). Although the function of a large number of these functional cell types has been studied in great detail, the developmental cues associated with fate decisions of a common progenitor remain highly …
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The Identification of a Leptin Dependent Neural Pathway Regulating Adipose Tissue Innervation
… We identified LepR expressing neurons in the arcuate nucleus of hypothalamus (ARC) as regulators of SNS innervation. In WT mice, either genetic deletion of LepR in ARC or diet induced leptin signaling loss in ARC leads to dramatic SNS innervation reduction in both BAT and iWAT. There are two …
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Neural Mechanisms of Homeostatic Need and Reward
… a marker of mTOR activity, were increased in the arcuate nucleus (ARC) and other hypothalamic nuclei in DIO mice. Subsequent multi-modal single-nucleus RNA sequencing of the ARC in DIO, chow-fed and ob/ob mice revealed that rapamycin altered gene expression exclusively in POMC neurons of DIO mice …