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Showing 1 to 20 of 136 for “"arachidonic acid"”.
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Intracellular signalling by arachidonic acid metabolites
In intrauterine tissues, pro-inflammatory cytokines and prostaglandins (PGs) have been identified as key mediators in the maintenance of pregnancy and parturition. The rise in PGD2 detected in the amniotic fluid before labour prompted the research presented in this thesis which describes the …
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Vitamin E and arachidonic acid metabolism in cultured human endothelial cells.
… and its subsequent effect on the metabolism of arachidonic acid were conducted on human umbilical vein endothelial cells (HUVECs) in culture. HUVECs incorporated physiological and pharmacological concentrations of RRR-$\alpha$-T in a time- and dose-dependent manner. Incorporated tocopherol was …
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Modulation of Arachidonic Acid Metabolism in Rat Peritoneal Macrophages Through Nutritional Means
Embargo set by: Seth Robbins for item 78657 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs
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Roles of proteasome, arachidonic acid, and oxytocin in bovine myoblast proliferation and differentiation
… the second study was to determine the effects of arachidonic acid (AA) and its major metabolites prostaglandin E2 (PGE2), PGF2a, and PGI2 on myoblast proliferation, differentiation and fusion. Treating myoblasts with 10 μM AA, 1 μM PGE2, 1 μM PGF2α, and 1 μM PGI2 for 24 h each increased the number …
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Influence of the reducing agent triphenylphosphine on cyclooxygenase-1 metabolism of arachidonic acid
… (COX) metabolizes the polyunsaturated fatty acid arachidonic acid (AA) to PGG2, a cyclic endoperoxide that also contains a hydroperoxide, which is subsequently reduced to an alcohol in the enzyme to yield PGH2. Reactions catalyzed by COX-1 are significantly influenced by lipid hydroperoxides. …
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The effect of the reducing agent triphenylphosphine on arachidonic acid metabolism by prostaglandin H2 synthase
… H2 synthase (PGHS) catalyzes the conversion of arachidonic acid to prostaglandin endoperoxide (PGH2), which is a precursor to a variety of prostaglandins that function as hormones. Gas chromatography combined with mass spectrometry is employed to look for the novel products produced by reaction …
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Arachidonic acid metabolism by early ovine embryos and the role of prostaglandins in one aspect of embryonic development
… early ovine embryos were capable of metabolizing arachidonic acid. Cyclic ewes were estrous synchronized with 6⍺-methyl-17β-hydroxy progesterone acetate (MPA) pessaries, superovulated with follicle stimulating hormone (FSH) and bred artificially. Embryos were collected on d 4, 8, 10, 12 or 14 of …
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Regulation of tumour necrosis factor receptor expression on neutrophils by arachidonic acid and other long chain fatty acids.
… lipids, such as the pro-inflammatory 00-6 fatty acid, arachidonic acid (AA) and its metabolites. Cellular activation leads to the release of AA from membrane phospholipids. AA regulates the function of many cell types including neutrophils. In view of the known pro-inflammatory properties of AA …
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Regulation of Arachidonic Acid Pathway and Eosinophilic Inflammation in Chronic Rhinosinusitis/ Nasal Polyposis. Potential Role of Staphylococcus aureus Enterotoxins
linked to inflammation. Furthermore, EP2 and EP4 receptor expression was increased in chronic rhinosinusitis and nasal polyp subjects in contrast to EP1 and EP3, which were down regulated in the polyp group, suggesting a distinctive role of these receptors in the pathophysiology of nasal polyposis. …
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The role of dietary arachidonic acid and docosahexaenoic acid in preventing the phenotype observed with highly unsaturated fatty acid deficiency
… physiological roles of highly unsaturated fatty acids (HUFA), mainly arachidonic acid (AA, 20:4ω6) and docosahexaenoic acid (DHA, 22:6ω3), are not completely understood. In order to study specific functions for AA and DHA, a delta-6 desaturase knockout (D6D-/-) mouse was created. D6D is a key …
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EVALUATION OF THE OXIDATIVE METABOLITES OF ARACHIDONIC ACID AND THEIR IMPLICATION IN THE PROGRESSION OF INFLAMMATORY DISEASES: HYPERTENSION AND RHEUMATOID ARTHRITIS
… assessed, as well as the mechanism that produces arachidonic acid (AA) metabolites (eicosanoids). Eicosanoids are specific biomarkers of inflammation. Their biosynthesis from arachidonic acid can be catalyzed by either free radicals or enzymes such as lipoxygenases (LOX), cyclooxygenase-2 (COX-2) …
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Involvement of Cytochrome P450 1A in the toxicity of aryl hydrocarbon receptor agonists : alteration arachidonic acid metabolism and production of reactive oxygen species
… scup (Stenotomus chrysops), alteration of arachidonic acid (AA) metabolism and production of reactive oxygen species (ROS). In scup hepatic microsomes, cytochrome P450s including CYP1A and CYP2B-like proteins catalyzed regioselective metabolism of AA to eicosatrienoic and …
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Studies on the mechanism of human natural (NK) cell-mediated cytotoxicity (CMC): the role of lipoxygenation and arachidonic acid metabolites in NK-CMC
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Depletion of docosahexaenoic acid (DHA) and arachidonic acid causes male infertility by disrupting both secretory granule biogenesis and adherens junction assembly in testis
An insufficiency in omega-3 fatty acids has been linked to a wide variety of health concerns including Alzheimer’s disease, CHD, sub-optimal fetal development and male infertility. The long chain omega-3 docosahexaenoic acid (DHA) and omega-6 arachidonic acid (ARA) are highly unsaturated fatty …
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Studies on intracellular calcium pools in a pancreatic cell line
… some cells, guanosine 5'-triphosphate (GTP) and arachidonic acid are known to mobilize intracellular Ca²⁺ independent of the action of IP₃ and probably play important roles in Ca²⁺ signalling. In pancreatic ductal cells the precise mechanisms of intracellular Ca²⁺ movement however are not well …
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The Putative Role Of Fatty Acids In The Activation Of Trehalose Synthesis In The Fat Body Of The Cockroach Periplaneta Americana L
… increase the concentration of several fatty acids in cockroach fat body trophocytes. The phospholipase A{dollar}sb2{dollar} (PLA{dollar}sb2){dollar} activator melittin has a similar effect. The fatty acids include palmitic, stearic, oleic and linoleic acid. The hormone mediated release of …
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Diversity and characterization of novel Cytochrome P450 2 genes in the marine teleost Fundulus Heteroclitus
… a baculovirus system, and their metabolism of arachidonic acid was examined. CYP2N 1, CYP2N2, and CYP2P3 metabolized arachidonic acid at respective rates of 435, 95, and 135 pmol/nmol CYP/min forming a variety of eicosanoids including epoxyeicosatrienoic acids 14,15-, 11,12-, and 8,9- and …
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Methyl esterification of fatty acids and eicosanoids with a novel reagent trimethylsilyldiazomethane for analysis by gas chromatography-mass spectrometry
<p>Fatty acids are compounds with limited water solubility that belong to the lipid class of bio-organic compounds and can be utilized as a source of energy by the body or as precursors to oxidized compounds that have roles in inflammation and in the regulation of vascular tone. The prostaglandins …
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