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Showing 1 to 15 of 15 for “"arachidonate"”.
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Arachidonate 15-lipoxygenase and ubiquitin as potential fertility markers in boars
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] This study was performed to determine whether using high power microscopic analysis and two putative biochemical fertility markers, 15-lipoxygenase (15-LOX) and ubiquitin (UBI), could be used to accurately evaluate boar semen …
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Effect of Fatty Acid Modification on Prostacyclin Production in Cultured Human Endothelial Cells (Arachidonate, Elcosapentaenoate)
An endothelial cell culture system was used to compare the effects of endogenous arachidonic acid (AA) and eicosapentaenoic acid (EPA) on prostacyclin synthesis. Supplemental levels of fatty acids (20-150 (mu)M) were supplied as sodium salts bound to bovine serum albumin (3:1 mole ratio) and added …
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In Situ Regulation of Cytosolic Phospolipase A₂
… intracellular signal transduction through the arachidonate cascade.<em> In vitro</em> studies have demonstrated that this enzyme is regulated by sub-micromolar calcium and is specific for arachidonate as the sn-2 fatty acyl group of phospholipid substrates. However, very little data is …
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Arachidonate oxidation metabolite profiles for myoglobin and a structurally altered form of myoglobin produced in muscle disease or trauma
<p>Myoglobin (Mb) and Myoglobin-H (Mb-H) react with glycerophosphocholine (GPC) lipid in the presence of oxygen. This reaction allows the heme group in the protein the chance to induce peroxidation reactions with the lipid. Several aldehyde products of this type of reaction with arachadonic acid …
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Signal transduction in macrophages. Intracellular pathways activated by microbial constituents
… and eicosanoids. Many microbial agents elicit arachidonate release in macrophages that lead to the formation of eicosanoids. This thesis is based on studies performed with the use of microbial constituents which induce arachidonate release or/and TNF? production. Whole gram-positive bacteria …
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Lipid oxidation in food and model system
… and the thermal decomposition products of methyl arachidonate were examined. Ferrous acetate was added to beef roasts and steaks at 15 to 300 ppm of iron, cooked, and stored at 3.3$\sp\circ$C for 48 hrs. TBA values and off-flavor scores indicated that iron addition enhanced lipid oxidation. Vacuum …
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The Synthesis, Separation, and Identification of Methyl Arachidonate Hydroperoxide Positional Isomers and Their Effect as Components of Large Unilamellar Vesicles on Vesicle Calcium Ion Uptake
Lipid peroxidation has been shown to occur in vitro and in vivo. Physiologically, the process appears to be especially important in detoxification reactions and in prostaglandin and leukotriene production. It has been linked with in vivo aging and peroxides of linoleic and arachidonic acids have …
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Protein -Protein Interactions of Synucleins: Implications for Normal Function and Neurodegenerative Disease
… work has demonstrated that the fatty acid, arachidonate, accelerates AS self-association, a process that may be involved in Parkinson's disease. The final chapter presented here shows that arachidonate also interferes with alpha-synuclein's inhibition of PLD2.
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The modulation of cytochrome P450 activities by their membrane lipid environment
… the main hydrolysis product was revealed to be arachidonate. Although the bulk fluidity of the membrane was unchanged at specific PLA2 concentrations, differential sensitivities of the GYP isoforms were observed at these concentrations. By assaying the activity of the NADPH-P450 reductase …
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Cutaneous Biophysical Characteristics of Melasma
… receptor alpha (PPAR-α), and arachidonate 15-lipoxygenase, type B (ALOX15B). Results: The melanin index, erythema index, and SC hydration were significantly higher in lesional skin compared to nonlesional skin, whereas the measurement of basal TEWL showed no significant …
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Mechanisms of ion channel activation in primary cultured and clonal cell lines
… that occurred approximately 90 s after onset of arachidonate superfusion. Arachidonic acid also induced kinetic modifications of the current which were evident as an acceleration of the time-dependent· inactivation exhibited at depolarised potentials. Inhibitors of cyclo-oxygenases, lipoxygenases …
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Hypoglycemia-induced changes in glucose metabolism in the hypothalamus
… with diabetes. We also identified changes in arachidonate 15-lipoxygenase (Alox15) gene expression, which is an enzyme that oxidizes polyunsaturated fatty acids, phospholipids, and other complex substrates. Alox15 expression was highly correlated with the hypoglycemia treatments and was …
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Saturation and isomerization of dietary fatty acids influence nutrient absorption and metabolism in the chicken
… receiving HT and HS than in those fed ML and HP. Arachidonate was present in greater concentrations when birds were fed ML, HP, and HS than when fed HT. Trans isomers were present only in the BBM from chickens fed HT. In Experiment 3, the effects of supplemental dietary lipidS on 1) the lipid …
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Muscle catabolism in cancer and its attenuation by eicosapentaenic acid
… of the n-6 polyunsaturated fatty acid- arachidonate. Employing the murine myoblast cell line C2C12, it was shown that both PIF and 15-HETE increased protein degradation and expression of proteasome subunits, processes which were again attenuated by prior incubation in EPA. Similarly, in …
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Ceramide Accumulation in the Alpha Cell Drives Glucagon Secretion and Hyperglycemia
… hormone-like prostaglandins were derived from arachidonate -- an essential free fatty acid. Since this biosynthetic precursor has many roles in metabolic processes, researchers gained interest in the functions that lipids and their metabolites might play in other cellular processes (William W. …