Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"aqueous humor"”.
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Hydrodynamics of aqueous humor outflow
… by a pathologic increase in the resistance to aqueous humor outflow from the eye. Currently, the physiological and ultrastructural bases for the generation of aqueous humor outflow resistance remain unclear in both the normal and glaucomatous eye, although experimental evidence suggests that …
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The flow of aqueous humor in microporous materials
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1987.
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A Novel Squid Glaucoma microShunt for Controlled Release of Aqueous Humor
… extensive surgical dissection, 2) uncontrolled aqueous humor (AH) release risking vision loss, and 3) prolonged inflammation and fibrosis leading to a complication rate over 50% at 5 years. To address this clinical need, we developed a novel GDD, the Squid Glaucoma microShunt (SGS) which has …
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The source of proteins in the aqueous humor of the eye
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Health Sciences and Technology, 1990.
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The role of vessel collapse on the flow of aqueous humor
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1981.
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Characterization of proteins and tissue remodeling components in porcine aqueous humor
… gender on MMP and protein activity in porcine aqueous humor were determined in this study to identify correlations existing between MMP activity and glaucoma risk factors. Gelatin zymography identified MMPs at 66 kD and approximately 105 kD. The concentration of the 66 kD band compared to human …
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Vascular Endothelial Growth Factor in the Aqueous Humor of Dogs With and Without Intraocular Disease
… hemorrhage. Elevated VEGF concentrations in the aqueous humor and vitreous are documented in a number of human intraocular disease processes, including tumors, retinal detachment and uveitic glaucoma. Pharmacotherapy inhibiting VEGF expression demonstrates promise for control of some of these …
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Aqueous humor concentration and prostaglandin E2 suppression efficacy of topically applied ophthalmic ketorolac 0.5% and diclofenac 0.1% solutions in dogs with cataract
… times in the 24-hour period pre-operatively. Aqueous humor samples were obtained intra-operatively and stored for subsequent evaluation of drug concentrations and prostaglandin E2 (PGE2) concentrations via ultra performance liquid chromatography-mass spectrometry (UPLC-MS/MS) and enzyme-linked …
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Structural and functional investigation of the trabecular outflow pathway
… intraocular pressure (IOP), caused by increased aqueous humor outflow resistance. Currently, lowering the IOP is the only effective way of treating glaucoma; however, the cause of increased outflow resistance remains unclear. This thesis will present a series of studies which investigated …
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Biomechanical characterization and computational modeling of the anterior eye
… forces are caused by the continuous flow of the aqueous humor (AH) in the anterior eye. An accurate and predictive computational model, which could provide insights into pathophysiology of glaucoma and possibly lead to novel therapeutic strategies, must accounts for all of the three elements …
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Cloning and Sequencing of Bovine Na+/K= Atpase α-1 Sub-Unit
… and ions from and through the cornea into the aqueous humor, it is responsible for maintenance of structural integrity, corneal hydration and thereby transparency of the cornea. The Na+ pump is characterized by a complex molecular heterogeneity that results from differential association of …
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Effect of Hydrogen Sulfide Donors on Sympathetic Neurotransmission and Intraocular Pressure of the Eye
… with a balance in the inflow and outflow of aqueous humor, a transparent fluid responsible for maintaining IOP. Existing therapies include medications either reducing aqueous humor production or strategies improving its drainage in order to restore the normal IOP. However these therapies are …
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Tissue-engineered in vitro models for studying lymphatic morphogenesis, pathogenesis, and drug delivery
… conditions. Specifically, I first describe the aqueous humor outflow model that incorporates trabecular meshwork and Schlemm’s canal, and TGF-β1/ALK5/VEGFC signaling axis in steroid-induced glaucoma. Then, I discuss the double-casting sacrificial 3D printing method to study lymphatic valve …
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Modeling, simulation and applications of ionic polymer metal composites
… micropump implant in order to remove excess aqueous humor that may be causing Glaucoma. Therefore, in this study, a low energy IPMC micropump is simulated, in which the fluid is driven by deformation of two IPMC diaphragms. Results show that micropump has the ability to transfer mentioned …
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The Relationship of Trabecular Meshwork Stiffness and Outflow Function
… that plays a major role in regulating outflow of aqueous humor of the eye and setting intraocular pressure (IOP). TM dysfunction may lead to ocular hypertension which is the major risk factor in glaucoma. Although the outflow properties of the TM have been assessed over the last sixty years, very …
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The Immunopathogenesis of HLA B27-associated Spondylarthritis and Acute Anterior Uveitis
… study showed that lumican was present in the aqueous humor of eyes in patients with AAU. Furthermore, immunohistochemical studies did show it is present in the iris and associated blood vessels, the site of inflammation of AAU. Additionally it was found that lumican has sequence homology with …
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Ocular pharmacokinetics and efficacy of various amino acid and dipeptide prodrugs of ganciclovir
… goals were set to prepare high dose topical aqueous solutions and to increase ocular bio-availability of GCV. A series of dipeptide monoester prodrugs and amino acid monoester and diester prodrugs were designed to target the nutrient transporters peptide transporter (hPEPT1) and sodium …
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Phenotypic Characterization of Segmental Human Trabecular Meshwork Cells
Purpose: Aqueous humor outflow is segmental in the trabecular meshwork (TM) with regions of high-flow (HF) or low-flow (LF) that vary in molecular signature, biomechanics, and response to pressure in both normal and glaucoma eyes. We sought to investigate whether cells in these regions (1) deposit …
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Microfluidic-based 3D cell culture for studies of biophysical and biochemical regulation of endothelial function
… of the circulation. For the second assay, an aqueous humor (AH) outflow model was developed. Subsequent proof-of-concept experiments confirmed its capability for studying the role of the inner wall endothelium in the regulation of AH outflow dynamics.
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Role of IL-17A and Acaid in the Maintenance of Corneal Immune Privilege
… molecules and membrane molecules present in the aqueous humor and on the surface of corneal cells layers, and (b) cell-mediated regulatory mechanisms such as anterior chamber-associated immune deviation (ACAID) that suppress systemic immune responses. This dissertation proposal investigates the …
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