Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"aquaporin 4"”.
-
Aquaporin-4 mediates blood brain barrier permeability during endotoxemia
Aquaporin-4 (AQP4) is a water channel expressed on astrocytes known to regulate the exchange of fluids and solutes between the parenchyma of the central nervous system (CNS) and perivascular spaces. We hypothesized that activation of AQP4 may mediate permeability of the CNS during systemic …
-
Aquaporin 4 and Kir4.1 Distribution in Retinal Glial Cells of Normal Macaque Eyes and Eyes with Experimental Glaucoma
… the study was to determine the distribution of aquaporin 4 (AQP4) and a potassium inward rectifying channel (Kir4.1) in the Müller glia and astrocytes of the normal macaque monkey retina and to see how the distribution changed in eyes with experimental glaucoma. Methods: Five Rhesus macaque …
-
Systematische Charakterisierung und Untersuchung der Inzidenz von Myelitis-assoziierten Autoantikörpern bei akuten Myelitiden
… von Myelin-Oligodendrozyten-Glykoprotein (MOG), Aquaporin-4 (AQP-4) und glial fibrillary acidic protein (GFAP) Antikörpern bei PatientInnen mit Myelitis im Vergleich zu einer Kontrollkohorte. Es erfolgte eine retrospektive Rekrutierung von PatientInnen mit Myelitis und einer Kontrollkohorte. …
-
Clearance systems at brain borders
… disease, which was associated with increased aquaporin-4 polarization along astrocytic endfeet, dilated meningeal lymphatic vessels, and amyloid accumulation in cervical lymph nodes. Inhibiting glymphatic clearance abolished the removal of amyloid by multisensory 40 Hz stimulation. Using …
-
Role of Astrocyte Network in Edema after Juvenile Traumatic Brain Injury
… to have a central role in the edema process: Aquaporin 4 (AQP4) and Connexin 43 (Cx43). AQP4 is expressed extensively in astrocyte endfeet, which surrounds the blood vessels as part of the blood brain barrier (BBB). Cx43 is central in astrocyte to astrocyte connection and communication. We …
-
Genetic exploration of exercise associated sudden death in racehorses
… to known human ion channelopathy genes, aquaporin 4 (AQP4) and potassium channel tetramerization domain containing 1 (KCTD1) on the region in chromosome 8, showed potential relevance to dysrhythmia development. Specific Aim 2: This study aimed to identify causative variants in …
-
Oxygen resuscitation does not ameliorate neonatal hypoxia/ischemia-induced edema
Neonatal hypoxia/ischemia (HI) is the most common cause of developmental neurological, cognitive and behavioral deficits in children. Although cerebral edema is a common outcome after HI, the mechanisms leading to the excessive fluid accumulation are poorly understood. Hyperoxia treatment after HI …
-
NEUROBIOLOGIA DEL SUICIDIO NEL DISTURBO DEPRESSIVO MAGGIORE: STUDIO MORFOLOGICO POST-MORTEM PER L¿INDAGINE DEL NETWORK GLIALE E VASCOLARE, CON ANALISI TOSSICOLOGICHE PER LA VALUTAZIONE DELL¿ADERENZA ALLA TERAPIA PSICHIATRICA
… S100β – calcium binding protein S100β –, AQP4 – Aquaporin-4 –, ALDH1L1 – Aldehyde Dehydrogenase 1 Family Member L1) showed a trend toward increased cell number and marker expression in suicide cases, particularly in the dorsolateral prefrontal cortex (dlPFC) and white matter. GFAP/S100β …
-
An audit of the epidemiological, clinical features and outcomes of patients with Neuromyelitis Optica Spectrum Disorder (NMOSD) attending a South African Tertiary referral Hospital
… optic neuritis and myelitis. The pathogenic anti-aquaporin-4 antibody is present in most cases and distinguishes it from other forms of inflammatory CNS demyelination. This biomarker has led to recognising a broader clinical spectrum of NMOSD. Another recently discovered antibody, the …
-
An <i>in vitro</i> human 3D co-culture model to study endothelial-astrocyte interactions
… namely, glial fibrillary acidic protein (GF AP), aquaporin-4 (AQP4), endothelin-l (Et-l) and endothelin receptor type-B (EDNRB), were compared between 3D and 2D cultured HA. The decreased expression of AQP4 and EDNRB and the much-decreased proliferation rate of 3D HA suggested their reduced …
-
Characterizing Changes in the Brain During Hydrocephalic Development and Exploring Potential Treatment Strategies
… wildtype (Tmem67+/+). These cells also contain aquaporins (AQP), aquaporin-1 (AQP1) and aquaporin-4 (AQP4), important in regulating CSF and interstitial fluid (ISF). Increased fluorescent intensity of AQP4 in the subventricular zone and increased AQP1 apical localization and protein amount in …