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Showing 1 to 6 of 6 for “"apurinic/apyrimidinic endonuclease 1"”.
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Discovery and Identification of New DNA Photoproducts and Investigation of the Redox Mechanism of Human Apurinic/Apyrimidinic Endonuclease 1 (hApe1) Protein
… thesis deals with a DNA-binding protein. Human apurinic/apyrimidinic endonuclease 1: hApe1) contributes to DNA repair by cleaving apurinic/apyrimidinic sites of damaged DNA. Additionally, hApe1 is a bifunctional protein functioning as a redox factor that simulates DNA binding activity of several …
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DNA Repair, Redox Regulation and Modulation of Estrogen Receptor Alpha Mediated Transcription
… Furthermore, we show that a second protein, Apurinic/apyrimidinic endonuclease 1 or redox factor-1 (Ape1/Ref-1), interacts with ERalpha, promotes the ERalpha-ERE interaction, influences ERalpha-mediated transactivation, and selectively associates with endogenous, estrogen-responsive genes in …
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The Choreography of Base Excision Repair
… act sequentially within the BER pathway: human apurinic/apyrimidinic endonuclease 1 (APE1) and DNA polymerase beta (Pol β). First, we report seven X-ray crystallographic structures that reveal how APE1 influences the conformations of a variety of different mismatched base pairs. We show that the …
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Targeted Inactivation of APE1 Endonuclease by E96A Mutation Sensitizes Pancreatic Ductal Adenocarcinoma to DNA-Damagin Therapy
… repair pathways essential for tumor survival. Apurinic/apyrimidinic endonuclease 1 (APE1/Ref-1) is a multifunctional protein with critical roles in base excision repair (BER) and redox regulation of transcription factors. This dissertation tests the hypothesis that selective disruption of APE1 …
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Atm-/-Ung-/- Mice Present Reduced Levels of Switched Immunoglobulin Isotypes IgG1 and IgG3
… (ATM), facilitates the interaction of AID with apurinic/apyrimidinic endonuclease 1 (APE1), suggesting that ATM may function in BER through p-AID. However, mice possessing a knock-in mutation altering their serine-38 site to an alanine and a <em>Ung</em><em><sup>-/-</sup></em> genetic mutation …
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Analysis of nuclear transport signals of the human apurinic/apurimidinic endonuclease (APE1/REF1)
The nuclear localization signal (NLS) in human apurinic/apyrimidinic endonuclease (APE1), a key protein in both DNA base excision repair and transcriptional regulation, has not been analyzed in detail. We examined the role of specific residues in nuclear translocation of APE1, using green …