Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"apoptotic signaling"”.
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TRP75-Mediated STAT3 Activation Promotes Anti-Apoptotic Signaling and Ehrlichia chaffeensis Infection
… mononuclear phagocytes by hijacking host cell signaling pathways to promote infection. In part, E. chaffeensis accomplishes host cell manipulation through the actions of secreted effector proteins, including the tandem repeat proteins (TRPs). The most well-characterized TRP, TRP120, uses …
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Discrete Transition System Model and Verification for Mitochondrially Mediated Apoptotic Signaling Pathways
… concentration in the model is realizable for a signaling pathway. Another interesting problem is to examine faulty pathways and how a fault can make a previously unrealizable state possible, or vice versa. Such analysis can be extremely valuable to the understanding of apoptosis. However, these …
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The Role of Nucleolin In B-Cell Lymphomas and Fas-Mediated Apoptotic Signaling
… to eradicate tumor cells and ineffective Fas-apoptotic signaling is a basis for primary as well as acquired resistance to chemotherapy. We hypothesized that Fas is subjected to direct regulation by inhibitory proteins attained by cancer cells. To screen for potential binding modulators of Fas, …
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Insights into p53-Dependent Apoptotic Signaling and Cell Fate vis-a-vis Functional Cooperation among BCL-xL, Cytoplasmic p53, and PUMA
… protein that binds and inhibits the anti‑apoptotic BCL‑2 repertoire, including BCL‑xL. Structural investigations of PUMA and the BCL‑xL×PUMA BH3 domain complex by X‑ray crystallography and nuclear magnetic resonance (NMR) spectroscopy reveal a novel, PUMA‑induced, domain‑swapped …
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Design, Synthesis and Evaluation of Diphenylamines as MEK5 Inhibitors
… other ligands to cell-surface receptors begin a signaling cascade that activates MEK resulting in phosphorylation of its corresponding and specific and parallel ERK (Extracellular signal-Regulated Kinase) substrate. The MEK5/ERK5 pathway is involved in cell survival, anti-apoptotic signaling, …
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Development of PAC-1 as a privileged agent for combination chemotherapy
… Synergistic enhancement in protein activity, signaling pathway activation and in vivo efficacy were observed. This substantiated the hypothesis that when orthogonal mechanisms of protein activation were possible, that dramatic enhancements in biologic effect could be observed, thereby …
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The Role of Peroxiredixin Ⅲ in the ototoxic drug-induced mitochondrial apoptosis of cochlear hair cell
… mitochondrial generation of H2O2 contributes to apoptotic signaling independently of the direct contribution of O2-. The intracellular accumulation of H2O2 caused by Prx III depletion resulted in accumulation of apoptosis, with increased rates of mitochondrial membrane potential collapse, …
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Effects of loigomycin, F0/F1 ATP-synthase inhibitor on mitochondrial morphology and dynamics
… not directly related to opening of mitochondrial apoptotic signaling and ROS is an important mediator in the fission process.
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Sulforaphane sensitizes TRAIL-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated upregulation of DR5
… for triggering and amplifying TRAIL-induced apoptotic signaling. We also found that SFN can sensitize both Bcl-xL- and Bcl-2-overexpressing hepatoma cells to TRAIL-induced apoptosis, indicating that treatment with a combination of TRAIL and SFN may be a safe strategy for treating resistant …
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Characterization of a Mitochondrial Localizing Molluscum Contagiosum Virus Protein: MC163R
… cell. Mitochondria are important moderators in apoptotic and anti-viral signaling. Many viral proteins that localize to the mitochondria affect mitochondria immune signaling pathways such as apoptosis. Preliminary data suggests that expression of MC163 inhibits TNF-induced mitochondrial membrane …
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The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking
… The aim of this thesis was to elucidate the signaling and membrane trafficking of GPR30 in addition to look for any binding partners. My primary findings were: (1) GPR30 constitutively internalizes without any need for ligand binding. (2) GPR30 associates with cytokeratin filaments (3) GPR30 …
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Design, Synthesis, & Biological Evaluation of Novel Het-Aromatic/Aromatic Analogs for the Treatment of HIV, Cancer, & Cognitive Dysfunctions
… <p>Mitogen-Activated Protein Kinase signaling cascades plays a critical role in cancer cell survival, metastasis, and chemo-resistance. The MEK5/ERK5 pathway, which is a member of MAPK signaling cascade, is involved in cell survival, anti-apoptotic signaling, angiogenesis, and cell …
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The co-modulation of apoptosis and the cell cycle
… theory that Bcl-2 plays an important role in apoptotic signaling pathways.
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Differential proteome analysis of human lung epithelial cells following exposure to aromatic volatile organic compounds
… stress response combined with moderate pro-apoptotic signaling. Measurement of cellular reactive oxygen species (ROS) as well as the styrene-mediated induction of oxidative stress marker proteins confirmed the hypothesis of oxidative stress as the main molecular response mechanism. Finally, …
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Molecular and Genetic Analysis of Parkin in Microglia Activation and Inflammation-Related Neurodegeneration
… in microglial activation and inflammatory signaling also affect DA neuron survival. Our biochemical analyses of primary wild type microglia show Parkin expression is negatively regulated by inflammatory stimuli. Pharmacological or genetic inhibition of NF-κB, a transcription factor …
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Caspase-dependent Signaling as an Inductive Cue for Cardiac Hypertrophy
… Here, we describe an essential role for apoptotic caspase-dependent signaling in the induction of pathological cardiac hypertrophy. Initially, we discovered that primary cardiomyocytes treated with hypertrophy agonists display transient activation of intrinsic-mediated …
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G-Quadruplexes As Molecular Targets For Transcriptional Control
… Decreases in Bcl-2 expression result in pro-apoptotic signaling. However, Bcl-2 G41 stabilization can cause transcriptional activation, and its upregulation reduces apoptosis, which is of therapeutic benefit for neurodegenerative diseases. The current study examines (a) the effect of …
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NEW INSIGHTS INTO THE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION DURING APOPTOSIS
… are effective for their ability to initiate the apoptotic process. Often this involves the activation of the mitochondria-mediated pathway. The existing paradigm of mitochondria-mediated apoptosis, which can be activated by DNA damage, indicates this pathway proceeds in a linear fashion. …
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The Role of ERK5 in Dopamine Neuronal Survival
… protected against 6-OHDA-induced increase in apoptotic signaling, as measured by caspase-3/7 activity at 6 h; indicating that GDNF and DNSP-11 blocks some, but not all, of the cytotoxic effects of 6-OHDA. Treatment of SH-SY5Y cells with GDNF or DNSP-11 resulted in activation of ERK1, 2, and 5 …
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Vitrification of Bovine Oocytes
… The specific goals were to assess changes in apoptotic gene expression (Fas-FasL, Bax, Bcl-2, and survivin) in conjunction with terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and caspase assays. Mouse zygotes were exposed to increasing concentrations of ethylene glycol …
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