Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"apoptotic proteins"”.
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Approaches Towards the Inhibition of Anti-Apoptotic Proteins
Anti-apoptotic proteins play a fundamental role in cell survival. Under physiological conditions, such proteins trigger apoptosis in defective or damaged cells only; under pathological conditions, however, they can be dysregulated allowing the cells to survive despite being harmful. Considering the …
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Development of Models for the Action of Novel Anti-apoptotic Proteins using Gene Regulation, Pathway Analysis and Protein Structure Prediction
… the predicted structures of some of the key proteins that regulate these pathways and networks. The wider aim of the work was to use these bioinformatics approaches to underpin and facilitate future efforts at designing novel anti-cancer drugs for ovarian and NSCLC. The specific objectives of …
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The investigation of microbial-intestinal epithelial cell interactions in the gut and their effects on inhibitor of apoptotic proteins (IAPs)
Probiotic bacteria such as Lactobacillus plantarum strain 299v (Lp299v) have been shown to upregulate facets of innate immunity. This study assessed whether Lp299v prevents apoptosis in intestinal epithelial cells (IECs) when faced with cytokine challenge. Both in vitro and in vivo systems were …
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Flexibility and specificity of the interaction of MCL-1 with BIM BH3
Interactions among proteins of the BCL-2 family regulate apoptosis - the process of programmed cell death. This thesis focuses on interactions between anti-apoptotic BCL-2 proteins and BH3 peptides derived from pro-apoptotic BCL-2 proteins, observed in earlier studies to occur with significant …
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Development of Specific Inhibitors that Prevent hnRNPA1-Mediated Therapy Resistance in Small Cell Lung Cancer.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a diverse family of RNA-binding proteins (RBPs) that are involved in many steps in gene regulation. The hnRNP family consist of 20 members which are expressed in humans (A1 to U). The first member identified being hnRNP A1; this is a …
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Procaspase-3 activation as a strategy to overcome resistance to targeted anticancer therapies
Apoptotic signals are tightly regulated in cells to prevent accidental or unwanted cell death. In cancer cells, however, multiple defects exist in the apoptotic machinery to evade programmed cell death. Commonly reported defects include the overexpression of anti-apoptotic proteins (e.g. Bcl-2, …
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Revelation of new properties of pro-apoptotic human proteins, Bax and α-synuclein, using baker's yeast
… as neurons. Bax and α-synuclein are two human proteins which play a role in the induction of neuronal apoptosis in neurodegenerative diseases like Alzheimer’s and Parkinson’s. Human Bax and α-synuclein also induce cell death when expressed in baker’s yeast, Saccharomyces cerevisiae. In this …
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Investigating Apoptosis Pathway In Chronic Lymphocytic Leukemia: Stromal Influence and Therapeutic Activation
… malignancy. High levels of Bcl-2 and IAP family proteins are responsible for apoptotic-resistance and accumulation of mature CLL lymphocytes in bone-marrow, lymph nodes and peripheral blood. Besides pro-survival proteins, supporting stromal cells as well as soluble factors in the microenvironment …
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The role of TNFAIP1 in regulation of LPS/TNF-ɑ-induced signaling pathway
… 20 hours; 4. Overexpression of TNFAIP1 induced apoptotic proteins, such as Bcl-x, Caspase 3, Catalase, Claspin, Cytochromic, HO-1/HMOX1/HSP32, MCL-1, P27/Kip1, or SMAC/Diablo; 5. TNFAIP1 promoter DNA was cloned into pGL3 basic plasmid DNA to determine promoter activity. TNFAIP1 promoter activity …
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Inhibition of Deubiquitinase Activity and Ubiquitination of Jak2 Blocks Cytokine Signaling and Induces Tumor Cell Apoptosis
… also induces accumulation of other ubiquitinated proteins without inhibiting 20S proteasome activity. Further analysis of the mechanism of action of WP1130 revealed that WP1130 acts as a partly selective DUB inhibitor. It specifically inhibits the deubiquitinase activity of USP9x, USP5, USP14 and …
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Small Molecule Inhibitors of HPV16 E6
… to and accelerating the degradation of several apoptotic proteins, including caspase 8 and p53. We proposed that blocking the interactions between HPV E6 and its partners using small molecules had the potential to re-sensitize HPV+ cells to apoptosis. To test this prediction, we screened …
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Regulation Of Apoptotic Alkalinization Through Phosphorylation Of Sodium Hydrogen Exchanger Via P38 Mitogen Activated Protein Kinase
… that a rise in intracellular pH activated apoptotic proteins leading to cytochrome C release. This "apoptotic alkalinization" occurred upon activation of the plasma membrane protein, sodium hydrogen exchanger-1 (NHE1), whose activity is regulated by the stress kinase p38 MAPK. In previous …
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Modeling and designing Bc1-2 family protein interactions using high-throughput interaction data
… regulating enzymatic activity. Understanding how proteins interact is essential for predicting new binding partners and engineering new functions. Mutational analysis is one way to study the determinants of protein interaction. Traditionally, the biophysical study of protein interactions has been …
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Human Cytomegalovirus Us17 Locus Fine-Tunes Innate And Intrinsic Immune Responses
… GPCRs and the bax inhibitor-1 family of anti-apoptotic proteins. We show that one member, US17, plays an important role during virion maturation. Microarray analysis of cells infected with a recombinant HCMV deleted for US17 (ΔUS17) revealed blunted host innate and interferon responses at …
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Non-genomic control of neuronal calcium signaling by the steroid hormone estrogen leads to neuroprotective effects
… factor and increasing the expression of anti-apoptotic proteins. However, the estrogen receptor also has non-genomic effects, and the changes occur too quickly after stimulus to have resulted from transcriptional changes. Although the genomic effects are well characterized, the non-genomic …
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Role of Macrophage Apoptosis in Atherosclerosis.
<p>The presence of apoptotic cells in atherosclerotic lesions has been broadly reported in the past ten years. The majority of these apoptotic cells are macrophages. However, the pathogenic role of macrophage apoptosis in the development of atherosclerosis remains to be elucidated. Elevated …
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Role of Pro-Apoptotic Bcl2-Homology-3 Domain (BH3)-Only Proteins in the Mutant SOD1 Mouse Model of ALS
… of intrinsic apoptosis are the Bcl-2 family proteins. While some members of this family are pro-survival, the Bcl-2 homology-3 domain (BH3)-only proteins are pro-apoptotic. Since cooperation of various BH3-only proteins is often necessary to induce apoptosis, we hypothesized that multiple …
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Effect of TIS21 on DNA Damage Repair Induced by Etoposide
… of apoptosis(PUMA), which are known to be pro-apoptotic proteins in p53-dependent apoptosis, were not induced in TIS21 infected Huh7 cells. Caspase 3/7 activity, chromatin condentation and annexin V staining data suggest that TIS21 inhibited Chk2-p53 DNA damage pathway. Furthermore, TIS21 …
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Impacts of perfluorooctanoic acid on porcine oocyte health and competence
… (BAX). We hypothesized that oxidative stress and apoptotic pathways would be affected by PFOA during the meiotic maturation period, and that co-exposure with albumin would mitigate these effects. To test this central hypothesis, porcine oocytes were exposed to increasing concentrations of PFOA, …
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Walleye dermal sarcoma virus Orf C: a potential oncolytic therapy
… basis. The WDSV genome encodes three accessory proteins (rv-cyclin, Orf B, and Orf C) that are necessary for regulation of virus expression, tumor formation, and tumor regression. While rv-cyclin and B are critical for tumor development, Orf C contributes to the observed seasonal tumor …
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