Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"apoptotic program"”.
-
Identification and Targeting of Therapeutic Resistance Mechanisms in Inflammatory Breast Cancer
… EGFR/ErbB1 and Her2/ErbB2 and defects in the apoptotic program. The development of therapeutic resistance is a significant barrier to successful treatment in IBC, and thus, strategies targeting the mechanisms that drive drug resistance could prevent or reverse therapeutic resistance, …
-
TRP75-Mediated STAT3 Activation Promotes Anti-Apoptotic Signaling and Ehrlichia chaffeensis Infection
… of STAT3 target genes, including the anti-apoptotic gene MCL1. Pharmacological inhibition of STAT3 significantly reduced MCL1 expression and increased caspase cleavage, implicating STAT3 as a regulator of anti-apoptotic signaling during infection. Furthermore, both pharmacological …
-
In Vivo Genome-Wide Analyses of the Drosophila p53 Transcriptional Network
… developing fly, p53 robustly activates important apoptotic genes in response to DNA damage to promote cell death. In the embryo model, we discovered an important p53 enhancer that forms chromatin contacts through long genomic distances and enables p53 to activate various genes. How p53 programs …
-
Genetic Determinants of Cancer Cell Survival in Tumor Microenvironment Stresses
… as with silenced ACLY or ACC1, including an anti-apoptotic program. Metabolomic analysis found that while α-ketoglutarate levels decrease under hypoxia in control cells, α-ketoglutarate was paradoxically increased under hypoxia when ACC1 or ACLY were depleted. Supplementation with α-ketoglutarate …
-
The Role of Chk2 and Wee1 Protein Kinases during the Early Embryonic Development of Xenopus laevis
… addition, cell cycle checkpoint pathways and an apoptotic program become functional. The studies described here were performed to better understand the roles of two protein kinases, Chk2/Cds1 and Wee1, during checkpoint signaling in the developing embryo. The DNA damage checkpoint is mediated by …
-
Characterization of Stress Responsive MicroRNAs and Their Roles in T Cell Development
… or glucocorticoids eliciting a rapid apoptotic program. MicroRNAs (miRs) are short, non-coding RNAs that play critical roles in the immune system by targeting diverse mRNAs. We hypothesized that a subset of thymically encoded miRs would be stress responsive and modulate thymopoiesis. …
-
Identification of a Novel Regulator of ER Stress-Induced Apoptosis
… If the ER cannot return to homeostasis, the apoptotic program is activated. Programmed cell death (apoptosis) is an evolutionarily conserved, genetically controlled program which eliminates excess or irreparably damaged cells and it is necessary to maintain tissue integrity. The failure to …
-
The Tumor Suppressor PKCδ Is Critical for UV-Induced G2/M Checkpoint Activation and Apoptosis
… is an essential component of the intrinsic apoptotic program. Following DNA damage, such as exposure to UV radiation, PKCδ is cleaved in a caspase-dependent manner, generating a constitutively active catalytic fragment (PKCδ-cat) which is necessary and sufficient for keratinocyte (KC) …
-
A Study on the Protein Interaction with Different Platinum Compounds
Since the discovery of anti-tumor activity of cisplatin in 1960, significant progress has been made in treating metastatic or advanced cancer with cisplatin and platinum compounds. Platinum compounds covalently bind to DNA and disrupt DNA function. They are also known to bind with amino acids like …
-
Ehrlichia chaffeensis Activates Notch Signaling Through SLiM Mimicry to Inhibit Apoptosis
… and has evolved molecular strategies to reprogram the host cell involving secreted effectors that interact directly with the host cell targets. Recently, we have shown E. chaffeensis evasion of innate defenses of the macrophage involve activation of Wnt, Hedeghog and Notch signaling …
-
The Dynamics of the Unreplicated DNA Checkpoint in Xenopus laevis Embryos and Extracts
… S and M phases, and establishes a functional apoptotic program. During the cell cycle, there are two main checkpoints that regulate entrance into S and M phases. The focus of this study is the role of protein kinase Chk1 and the phosphatase Cdc25A in the DNA replication checkpoint. In the …