Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"apoptosis signaling"”.
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Discrete Transition System Model and Verification for Mitochondrially Mediated Apoptotic Signaling Pathways
Computational biology and bioinformatics for apoptosis have been gaining much momentum due to the advances in computational sciences. Both fields use extensive computational techniques and modeling to mimic real world behaviors. One problem of particular interest is on the study of reachability, in …
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Role of CDC25 Phosphatases in Non-Melanoma Skin Cancer
… cell carcinoma (SCC) were dependent on Erbb2 signaling. Surprisingly, CDC25A and CDC25C did not stimulate proliferation in human SCC cells, but rather suppressed apoptosis. CDC25A-mediated suppression of apoptosis was dependent on its cytoplasmic localization and on interaction with 14-3-3ε …
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Direct Regulation of Apoptosis By Linear Ubiqutin Chain Assembly Complex (Lubac) and Feedback Regulation of Lubac Function By Caspases
… differentiation (mainly through NF-κB signaling) and death (via apoptosis signaling). Recently, linear ubiquitination by LUBAC (linear ubiquitin chain assembly complex) was reported to have a regulatory function in TNF-α mediated NF-κB activation. Although LUBAC is suggested to control …
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Interplay of Brain Derived Neurotrophic Factor and Protein Kinase A in Modulating Mitochondrial Structure and Function in Brain Homeostasis and Disease
… rapid endocytosis and translocation of the signaling endosome to the mitochondria leading to elevated activation of Protein Kinase A (PKA). BDNF-mediated activation of mitochondrial PKA led to an increase in phosphorylation of fission modulator Drp1, and of mitochondrial adaptor protein …
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The Signaling Pathway of Oxysterol-Induced Apoptosis in Macrophages.
… the major cytotoxic component of OxLDL, induce apoptosis in macrophages by a calcium flux mediated activation of cytosolic phospholipase A<sub>2</sub> resulting in the release of arachidonic acid (AA). Inhibition of AA metabolism has been shown to protect macrophages from oxysterol-induced …
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Targeting Apoptotic Pathways to Overcome Drug Resistance In Acute Myeloid Leukemia
<p>Evasion of apoptosis is integral to tumorigenesis and drug resistance. BCL-2 and p53 proteins represent two focal nodes in convergent apoptosis signaling. Upregulation of anti-apoptotic BCL-2 family members and inactivation of p53 functions are two canonical approaches exploited by cancer cells …
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Trabecular Calcium Phosphate Scaffolds for Bone Regeneration
… an osteoblast precursor cell line. Cell stress signaling was identified in response to the 3-D architecture using; members of the mitogen activated protein kinase cascade, cell survival signals and adhesion dependant proteins. The application of low intensity pulsed ultrasound (LIPUS) or fluid …
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Variability and Dynamics of Apoptotic Events in Single Cells
<p>Apoptosis is a form of programmed cell death that is necessary for development and organism homeostasis. The early stages of apoptosis are marked by the permeabilization of the mitochondrial outer membrane, the release of cytochrome c and Smac from mitochondria, and the activation of the caspase …
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The role of death-associated protein kinase in endothelial apoptosis under fluid shear stress
… physical and chemical stimuli into intracellular signaling cascades which in turn regulate cell function, and endothelial dysfunction leads to inflammation and diseased conditions. For example, atherosclerosis, a chronic vascular disease, favorably develops in regions of disturbed fluid flow and …
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Mechanisms of soy isoflavones in the regulation of vascular function
… tumor necrosis factor-alpha (TNF-α)-induced apoptosis in human aortic endothelial cells (HAECs). The results demonstrated that genistein, at physiologically achievable concentrations (1-10 μM) in individuals consuming soy products, enhanced the expression of eNOS protein and subsequently …