Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"apoptosis pathway"”.
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Novel Role of CHK2 in the Intrinsic and Extrinsic Apoptosis Pathway
… stress, cells activate DNA damage checkpoint pathways that maintain genetic fidelity, promote cell survival, and prevent malignant transformation. Checkpoint kinase 2 (CHK2) is an evolutionarily conserved serine/threonine protein kinase that is activated in response to DNA double strand …
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Investigating Apoptosis Pathway In Chronic Lymphocytic Leukemia: Stromal Influence and Therapeutic Activation
… on the regulation of apoptotic pathway proteins in the context of microenvironment is still limited. To address this, the first part of our study focused on comprehensive analysis of 93 gene transcripts from seven families that are key regulators of apoptosis such as Bcl-2, IAPs, …
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Overexpression of Amyloid Precursor Protein Induces Mitochondrial Oxidative Stress and Activates the Intrinsic Apoptosis Pathway
… and nuclear fragmentation indicative of apoptosis. APP-induced apoptosis was blocked by a pan-caspase inhibitor, (BOC), glutathione (GSH), or co-expression of Bcl-2. APP caused depletion of mitochondrial GSH, induced opening of the permeability transition pore, and triggered cytochrome c …
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Direct Regulation of Apoptosis By Linear Ubiqutin Chain Assembly Complex (Lubac) and Feedback Regulation of Lubac Function By Caspases
… (mainly through NF-κB signaling) and death (via apoptosis signaling). Recently, linear ubiquitination by LUBAC (linear ubiquitin chain assembly complex) was reported to have a regulatory function in TNF-α mediated NF-κB activation. Although LUBAC is suggested to control not only NF-kB signaling …
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The role of cad,flash and fam129b in cancer cell survial and apoptosis
<p>Apoptosis is a normal process in the human body. However, apoptosis is desregulated in cancer cells. Most cancer cells gain resistance to apoptosis, leading to uncontrolled proliferation. In this dissertation, we identified three proteins, associated with apoptosis pathway. 1) CAD, a large …
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Relative effectiveness of inhibition strategies for control of biological signaling pathways
… inhibitors of particular enzymes in a signaling pathway. The efficiency with which an inhibitor inactivates its target can be characterized by the binding kinetics and thermodynamics. However, the overall efficiency with which the inhibitor shuts down a pathway or process, arrests a signal, or …
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Contributions to the Analysis of Biochemical Reaction-Diffusion Networks Stability, Analysis, and Numerical Solutions
… autoactivation of the effector caspase in the apoptosis pathway, the activation of the Akt/mTOR complex implicated in muscular growth, and twospecies population dynamics. In particular, we derive analytical expressions for the equilibrium points of a circular protein activation mechanism with …
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Genetic regulation of cell extrusion in caenorhabditis elegans
… activation of the caspase-mediated apoptosis pathway, which produces a corpse that is engulfed and degraded by phagocytic cells. Cell elimination can also occur by a different method, called cell extrusion, in which the cell to be eliminated is squeezed out from a layer of cells, …
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THE COMPARISON OF EFFECTS OF SYNTHETIC AND NATURAL ARACHIDIN-3 ON ROTAVIRUS INFECTED CELLS
… This suggested that the arachidins modified the apoptosis and autophagy pathways. To support these observations, transcripts of initiator genes in both pathways were investigated using qRT-PCR, and the expression of two effector proteins in the apoptosis pathway were measured. Only small changes …
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Molecular Mechanism of Parvovirus Infection
… protein, which plays a key role in inducing apoptosis during B19V infection of erythroid progenitor cells. Caspase-10 may serve as an initiator in apoptosis of both B19V-infected and 11kDa-expressing cells. In contrast, apoptotic cell death during MVC infection appears to be viral DNA …
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Anti-proliferative effect of methyl gallate isolated from mangifera pajang kosterman in selected cancer cell lines
… the cell cycle arrest and killing mechanism via apoptosis in selected cancer cell line. Chromatography methods were used in this study to isolate methyl gallate (C8H8O5) from methanol crude extract. Identification of the isolated compound was done by spectroscopic methods including infrared (IR), …
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Regulation of cytotoxic drug-induced apoptosis by death receptor 5 in human colon cancer cells
… to be overcome. Understanding the molecular pathway of 5-FU-induced apoptosis will help designing more effective cancer treatments. Chemotherapeutic drugs such as 5-FU are thought to trigger cell death via the intrinsic apoptosis pathway which involves caspase-9 activation as one of the …
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Nanosecond Pulsed Electric Field Induction of Programmed Cell Death Is Cell Type Dependent: An <i>in vitro</i> Study
… by eradicating the ubiquitous cancer hallmark of apoptosis evasion and enforcing cancer programmed cell death. To develop nsPEFs as an anticancer method, a comprehensive understanding of cell death mechanisms is required. The overall objective of this dissertation is to elucidate molecular …
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The Signaling Pathway of Oxysterol-Induced Apoptosis in Macrophages.
… the major cytotoxic component of OxLDL, induce apoptosis in macrophages by a calcium flux mediated activation of cytosolic phospholipase A<sub>2</sub> resulting in the release of arachidonic acid (AA). Inhibition of AA metabolism has been shown to protect macrophages from oxysterol-induced …
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A transthyretin-related gene and a neuroligin-like gene prevent 6-hydroxydopamine-induced dopaminergic neurodegeneration in <i>C. elegans</i>
… intoxication as mutations in the engulfment pathway largely suppress neuronal loss. Before being engulfed, dopaminergic neurons likely undergo a necrosis-like cell death − since mutations in apoptosis pathway genes do not prevent, but rather increase neurodegeneration. In addition, the …
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Studies of programmed cell death in the nematode caenorhabditis elegans
… "assisted suicide" that requires both the core apoptosis pathway and the engulfment pathway. egl-1 and ced-3 are expressed in the dying or undead cell in wild-type and engulfment-defective animals, and these genes are required for the B.al/rapaav cell death. In engulfment mutants the B.al/rapaav …
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EARLY GROWTH RESPONSE 1 (EGR1) AS A TUMOR SUPPRESSOR AND APOPTOSIS INDUCER IN RHABDOMYOSARCOMA
… RMS through inducing programmed cell death, or apoptosis. We found that EGR1 induced apoptosis through triggering the intrinsic apoptosis pathway and activating caspase cascades involving caspase 3 and caspase 9, which are essential mitochondrial apoptotic factors. Also, we observed the …
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Development of versatile drug delivery strategies using PLGA nanoparticles
… activation of the DR5 triggered extrinsic apoptosis pathway. Furthermore Anti DR5 mAbs conjugated NP loaded with camptothecin demonstrated significant cell toxicity; a result of synergistic efficacy between camptothecin delivery and DR5 triggered apoptosis.<br/><br/>In a third study, PLGA …
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Effects of Ubiquinol with Fluid Resuscitation following Hemorrhagic Shock
… (ROS) which are known to activate the intrinsic pathway of apoptosis and contribute to organ dysfunction.1 Ubiquinol is a potent free radical scavenger which is produced endogenously and functions as part of the mitochondrial respiratory chain.2 No study has been conducted to investigate the …
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From cancer gene expression to protein interaction: Interaction prediction, network reasoning and applications in pancreatic cancer
… Moreover, a network of related biological pathways for the PDAC data was constructed. In order to reason over molecular networks that are affected by dysregulation of gene expression, BioRevise was implemented. It is a belief revision system where the inhibition behaviour of reactions is …
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