Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"apoptosis inducing factor (AIF)"”.
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THE PROSURVIVAL ACTIVITIES OF APOPTOSIS-INDUCING FACTOR CONVERGE UPON THE REGULATION OF MITOCHONDRIAL METABOLISM, A NOVEL CELL DEATH PATHWAY, AND THE PROGRESSION OF PROSTATE CANCER
Apoptosis-inducing factor (AIF) is a mitochondrial NADH-oxidase originally discovered for its ability to trigger apoptosis through chromatin condensation and DNA cleavage. Although AIF is recognized for its apoptotic function, AIF-mediated cell death has emerged as an atypical cell death pathway; …
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High-Throughput Detection of Protein---Protein and Protein---Dna Interactions via Photonic Crystal Biosensors: Applications to Apoptosis Inducing Factor
… acid interaction targeted is the apoptosis inducing factor (AIF)---DNA interaction, which is critical for the mediation of caspaseindependent cell death in neurodegenerative disease and stroke. Protein---protein interactions were targeted by modifying the PC biosensor surface for …
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High-throughput detection of protein—protein and protein—DNA interactions via photonic crystal biosensors: applications to apoptosis inducing factor
… protein—nucleic acid interaction targeted is the apoptosis inducing factor (AIF)—DNA interaction, which is critical for the mediation of caspaseindependent cell death in neurodegenerative disease and stroke. Protein—protein interactions were targeted by modifying the PC biosensor surface for …
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High-Throughput Screening Development Using Photonic-Crystal Optical Biosensor
… such as transcription, DNA damage repair, and apoptosis. As such, small molecule disruptors of these interactions could be powerful tools for investigation of these biological processes, and such compounds would have great potential as therapeutics. Unfortunately, there are few methods …
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A Novel Cardiac Function of Sumo2/3 and Senp5 Dependent Pathway and Its Physiological Impact On Congestive Cardiomyopathy
… cell cycle, protein stability, and apoptosis. Although SUMO1 has been extensively studied so far, relevance of SUMO2/3 is unclear, especially in heart. Here we show that failing heart induces SUMO2/3 conjugation. Increased SUMO2/3-dependent modification leads to congestive heart …
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Impacts of perfluorooctanoic acid on porcine oocyte health and competence
… and abundances of superoxide dismutase (SOD1), apoptosis inducing factor (AIF), and BCL 2 associated X protein (BAX). We hypothesized that oxidative stress and apoptotic pathways would be affected by PFOA during the meiotic maturation period, and that co-exposure with albumin would mitigate …
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The discovery of small molecule inhibitors of poly(ADP-ribose) mediated cell death
… through methods that generate cell death by inducing DNA damage, such as chemotherapeutics and radiation therapy, is a major obstacle to overcoming the disease. Resistance occurs through the repair of single strand DNA breaks by the poly(ADP-ribose) (PAR) cycle, which is an enzymatic cycle …
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Nanosecond Pulsed Electric Fields Induce a Mitochondria-Independent Apoptosis in B16F10 Melanoma Cells <i>In Vitro</i>
… field and biological effects that initiate apoptosis. Here the application of ten 300ns pulses ranging in electric fields from 12kV/cm-60kV/cm was administered to determine the effects on B16F10 melanoma cells evaluated by <em>in vitro</em> studies. Initial application of nsPEFs demonstrated …
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Reactive Oxygen Species-Induced Necrotic Cell Death
Mechanisms of cell death extend beyond the simple apoptosis/necrosis relationship to include regulated modes of cell death that do not readily fit either of the classic descriptors. One such mechanism of cell death involves poly(ADP-ribose)polymerase-1 (PARP-1)-mediated cell death. …
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Study of Regulated Cell Death In Two Systems: Pd-1 In Natural Killer Cells and Rip3 In Neurons
… starvation is another critical contributing factor. There are at least two key downstream molecules of RIP3 for acidosis/starvation-induced cell death: mixed lineage kinase domain-like pseudokinase (MLKL) and mitochondrial apoptosis-inducing factor (AIF). Inhibiting RIP3 by an FDA approved …