Global ETD Search

Familial Defective binding apolipoprotein B-100 the Cape Town Experience

Mahala, BonginkosiDepartment of Medicine2009

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Monogenic hypercholesterolemia in South Africans : familial hypercholesterolemia in Indians and familial defective apolipoprotein B-100

Rubinsztein, David ChaimDivision of Medical Biochemistry and Structural Biology1993

LDL-receptor mutations and familial defective apolipoprotein B-100 (codon 3500) (FOB), the known causes of monogenic hypercholesterolemia (MH), have similar clinical features. The nature of the mutations responsible for MH in South Africans of Indian origin was previously unknown. Similarly, the …

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Development of a Passive Immunization Strategy Against Atherosclerosis

Schiopu, AlexandruDepartment of Clinical Sciences, Lund University2006

… are aldehyde-modified peptide sequences of apoB-100, the main protein in LDL structure. Immunization of atherosclerosis-prone mice with some of the apoB-100 peptides reduced plaque area by up to 60% in the immunized mice compared to controls. We tested the effects of recombinant human IgG1 …

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