Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 28 for “"apolipoprotein B"”.
-
Monogenic hypercholesterolemia in South Africans : familial hypercholesterolemia in Indians and familial defective apolipoprotein B-100
LDL-receptor mutations and familial defective apolipoprotein B-100 (codon 3500) (FOB), the known causes of monogenic hypercholesterolemia (MH), have similar clinical features. The nature of the mutations responsible for MH in South Africans of Indian origin was previously unknown. Similarly, the …
-
The New Role of Proprotein Convertase Subtilisin/Kexin Type 9: A Connection of Proprotein Convertase Subtilisin/Kexin Type 9, Apolipoprotein B, and Autophagy
… by us; we observed PCSK9 interacted with apolipoprotein B (apoB) and increased apoB production, irrespective of the LDLR.</p> <p>ApoB is the primary structure protein of LDL particle and it also serves as the ligand for the LDL receptor. There is ample evidence showing that the levels of …
-
Mechanism of lipid disorder in HIV infection: apolipoprotein-B kinetics, fat distribution, insulin resistance and adipocytokines in patients taking protease inhibitors or non-nucleoside reverse transcriptase inhibitors
… insulin resistance (HOMA), adipocytokine and apolipoprotein-B (apoB) kinetics was investigated in 12 HIV negative controls and 55 HIV-infected patients including antiretroviral treatment-naïve patients (n=15) and patients taking two nucleoside analogues plus either a protease inhibitor (PI, …
-
Apoliprotein B metabolism in hamster livers, studied in vitro
… male hamsters were selected to study aspects of apolipoprotein B metabolism. Isolated hepatocytes in suspension were compared with those maintained under tissue culture conditions. Liver slices were also prepared and compared with isolated suspended hepatocytes. Freshly prepared hepatocytes from …
-
Identification and Characterization of APOBEC1 mRNA Editing Targets: A Transcriptomics Approach
… insertion, deletion or modification. The Apolipoprotein B mRNA Editing Catalytic polypeptide 1 (APOBEC1) cytidine deaminase is an mRNA editing enzyme that modifies a specific cytidine in the apolipoprotein B (apoB) transcripts of small intestine enterocytes. APOBEC1-mediated cytidine to …
-
THE USE OF REPLICATION-DEFECTIVE ADENOVIRAL VECTORS FOR EXPRESSION OF PRIMORDIAL ATHEROGENIC LIPOPROTEINS IN MICE
The plasma concentration of apolipoprotein B (apoB)-containing lipoproteins is positively associated with several diseases, including atherosclerosis, type 2 diabetes and obesity. Hence, apoB may be a prime target for therapeutic intervention, particularly during its assembly. The molecular events …
-
Biomarcadores relevantes para diagnóstico precoce e prevenção de doenças cardiovasculares.
… a), lipoprotein associated phospholipase A2 , apolipoprotein AI / apolipoprotein B , natriuretic peptides and myeloperoxidase are biomarkers nontraditional whose predictive power and clinical application are under discuss ion . CRP, homocysteine , Lp (a) Lp - PLA2 and MPO act in …
-
The Molecular and Cellular Mechanisms for Nanoparticle Transport
… that cells use the LDL receptor to bind the apolipoprotein B and complement C8 proteins adsorbed on the nanoparticle surface to take up nanoparticles. Expression in the LDL receptor correlated with and thus predicted the amount of nanoparticle accumulation in mice organs. We also found that …
-
Transcriptome-Wide Characterization of APOBEC1-Catalyzed RNA Editing Events in Macrophages
… adenosine deaminases acting on RNA (ADARs) and Apolipoprotein B mRNA Editing Catalytic polypeptide-1 (APOBEC1). The ADARs and APOBEC1 were originally characterized as catalysts for previously characterized biologically important RNA-editing events that resulted in specific coding changes; study …
-
THE IMPACT OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN ON INTRACELLULAR HEPATIC NEUTRAL LIPID DISTRIBUTION AND TRAFFICKING
… protein necessary for conversion of apolipoprotein B into precursor lipoproteins and bulk triglyceride (TG) movement into the endoplasmic reticulum (ER) for precursor lipoprotein expansion. Invertebrate forms of MTP (e.g. Drosophila; dMTP) are capable of phospholipid (PL) transfer, …
-
Impatto del profilo lipidico sulla malattia aterosclerotica in due differenti coorti di pazienti ad alto rischio cardiovascolare
… several studies have shown that cholesterol-rich apolipoprotein-B-containing lipoprotein have a central role in the pathogenesis of atherosclerosis. Of note, ApoB-lipoproteins up to only approximately 70 nm in diameter [i.e., chylomicron remnants, smaller very low-density lipoproteins (VLDL), …
-
Apobec1-Mediated RNA Editing in Monocytes Contributes to Genetic Heterogeneity and Modulates Monocyte Activity and Development
… fully characterized in its role of editing the Apolipoprotein B (ApoB) transcript in the intestine, where the C to U modification changes a glutamate codon to a stop codon, creating a smaller version of the ApoB protein. Editing of ApoB is essential for the formation of the chylomicron, a lipid …
-
Microarray Analysis Identifies Novel Cholesterol Regulated Genes, Including Pcsk9 Which Regulates LDL Receptor Function and LDL Cholesterol Levels
… role in LXR transcriptional activity and/or apolipoprotein B metabolism.</p>
-
Apolipoprotein biosynthesis and turnover in mammalian small intestine
… liver) for the synthesis and secretion of plasma apolipoproteins, and contributes significantly to overall whole-body lipid dynamics. A prominent feature of the small intestine is its exposure to periodic loads of meals often containing dramatically varying amounts or types of food components, …
-
Comparison of Anthropometric Measurements of Abdominal Obesity as Predictors of Cardiometabolic Risk Factors: NHANES 2011-2014
… cholesterol (HDL-C), high non-HDL-C, and high apolipoprotein B. <strong>Statistical analyses performed</strong> Simple and multiple logistic regression analyses compared the odds ratio of each anthropometric measure for each cardiometabolic disorder. <strong>Results</strong> When analyzed in …
-
Identification of Host Factors Required for Hepatitis C Virus Infection
… was employed. This study identified that Apolipoprotein B, Microsomal Triglyceride Transfer Protein, and Apolipoprotein E, three proteins participated in the assembly of very low-density lipoprotein (VLDL) were enriched in membrane vesicles. It was demonstrated that agents inhibiting VLDL …
-
Biochemical and Structural Studies of RNA and DNA Editing Enzymes
… deaminase acting on tRNA) and APOBEC3G (apolipoprotein B editing catalytic complex 3G), which deaminate adenosine in the wobble position (position 34) of tRNA and converts cytidine to uridine in single stranded DNA, respectively. Described herein, is the biochemical and structural …
-
Effects of Vitamin E Supplementation in Late Gestation Cattle and Evaluation of Vitamin E, Cholesterol, and Phospholipid Relationships in Bovine Serum and Serum Lipoproteins
… serum and the lipoprotein fraction containing no apolipoprotein B (non-ApoB) from 1-2 weeks pre-calving to calving. Treatment group calves had higher vitamin E concentrations in serum and non-ApoB than control group calves. Treatment did not affect cholesterol or phospholipid concentrations in …
-
Genome-Wide Characterization of the Effects of Nucleic Acid Modifying Enzymes: Cytidine Deaminases and DNA Methylation
… the substrate of the orphan cytidine deaminase Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide 2 (APOBEC2). Next, I used whole-genome bisulfite sequencing to explore the distribution of 5-methylcytosine in Trypanosoma brucei. In both of these cases, results were inconclusive but …
Page 1 of 2