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Showing 1 to 20 of 191 for “"apolipoprotein"”.
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Apolipoprotein M – Studies of Structure and Function
Apolipoprotein M (apoM), a 25 kDa plasma protein, is found in all major lipoprotein classes, although the majority is found in high density lipoproteins (HDL). ApoM has been suggested to be involved in the formation of and adding to the antiatherogenic functions of HDL, but its function is still …
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ROLE OF APOLIPOPROTEIN A-V IN TRIGLYCERIDE METABOLISM
… gene cluster on human chromosome 11q23. Apolipoprotein A-V (apoA-V) plasma concentrations are low (~100-200 µg/L) in comparison to other apolipoproteins, yet exert significant effects on triglyceride homeostasis. To examine the basis for its low concentration in plasma, the secretion …
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Apolipoprotein E4 and SirT1 Interaction in Alzheimer’s Disease
… are still unknown. Εpsilon 4, an allele of apolipoprotein E (ApoE4), is currently the most important risk factor for Alzheimer’s disease. Individuals that inherit two copies of the ApoE ε4 allele have an approximately ten to thirty times increased risk of developing AD in comparison to …
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Apolipoprotein biosynthesis and turnover in mammalian small intestine
… liver) for the synthesis and secretion of plasma apolipoproteins, and contributes significantly to overall whole-body lipid dynamics. A prominent feature of the small intestine is its exposure to periodic loads of meals often containing dramatically varying amounts or types of food components, …
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A Characterization of the Effect of Apolipoprotein AII on the Structure and Function of Apolipoprotein AI in Reconstituted High Density Lipoproteins
… two main subclasses: a fraction which contains apolipoprotein (apo) AI and apoAII, and a fraction which contains apoAI but not apoAII. The effect of apoAII on the structure and function of apoAI in reconstituted HDL was investigated. ApoAII was labeled with the fluorescent probe dansyl chloride …
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Transcriptional Regulation of Chicken Apolipoprotein A-I Gene Expression
… between v-Jun and c-Jun in CEF, the chicken apolipoprotein A-I (apoA-I) gene has been identified in our laboratory as one of the target genes whose expression is repressed in response to v-Jun overexpression in CEF. The overall objective of this study is to investigate the underlying …
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Interaction of Human Apolipoprotein a-I With Dipalmitoyl Phosphatidylcholine
… (DPPC) bilayer lipid will react with human apolipoprotein A-I (apo A-I) to form lipid-protein micellar complexes. The reactivity of the lipid bilayer is dependent upon the physical state of the vesicle. Large vesicles with essentially planar bilayers do not form complexes except at …
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The Effects of Apolipoprotein E on Amyloid-beta Induced Neurodegeneration.
The Effects of Apolipoprotein E on Amyloid-beta Induced Neurodegeneration.
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Apolipoprotein E and propagation of pathological tau in Alzheimer’s Disease
… to AD pathogenesis and is mediated by glia. Apolipoprotein E (APOE) genotype is the strongest genetic risk factor for the late-onset AD, with APOE4 increasing risk and APOE2 conferring protection. The exact mechanisms by which APOE modulates AD risk remain to be comprehensively discerned. …
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Apolipoprotein E alters the association of neuroinflammation with Alzheimer's disease
… a multitude of contributing genetic factors. The apolipoprotein E (APOE) allele e4 imparts a dramatic increase in the risk of developing Alzheimer’s disease, but the exact mechanism of this relationship is unknown. The e4 allele is associated with increased Ab plaques, neurofibrillary tangles, and …
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Spontaneous Phosphatidylcholine Exchange Between Vesicles and Micellar Lipid-Apolipoprotein Complexes
… model lipoproteins were recombinants of bovine apolipoprotein A-I, egg PC, and cholesterol produced by cholate dialysis. Vesicles contained egg PC and cholesterol in varying molar ratios. Lipid exchange was followed by incubating radiolabeled vesicles (('3)H-PC, plus ('14)C-cholesterol oleate as …
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A Gain-of-Function Role of Apolipoprotein E2 in Melanoma Progression
… polymorphism of the secreted lipid transporter apolipoprotein E (APOE) plays important roles in the development of atherosclerosis and Alzheimer's disease. More recently, three common APOE alleles have been implicated as modulators of melanoma progression and survival. Melanoma patients born …
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Apolipoprotein E genotypes and Alzheimer disease in two black population groups
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Apolipoprotein E Activation and Phosphatidylcholine Substrate Requirements of Lecithin Cholesterol Acyl Transferase
The apolipoprotein activation of lecithin cholesterol acyl transferase (LCAT) by human apolipoprotein E (apo E) was investigated by incorporating apo E into discoidal complexes of egg phosphatidylcholine (egg-PC) and cholesterol by the cholate dialysis method. These complexes were systematically …
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