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Showing 1 to 4 of 4 for “"aplysia kurodai"”.
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Zur Vanadium(V)-katalysierten Oxidation von Bromid und deren Anwendung in der Synthese von Aplysiapyranoid A und strukturell einfacher, bromierter O-Heterocyclen
… als Schlüsselschritte in Totalsynthesen von Aplysiapyranoid A, einem hexasubstituierten, dreifachhalogenierten Tetrahydropyran-abgeleiteten Naturstoff aus Aplysia kurodai, sowie dessen 5-Epimer.
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Designed analogues of the aplyronines for use in antibody-drug conjugates
… marine macrolides, isolated from the sea hare Aplysia kurodai, that exhibit picomolar growth inhibitory activity in the NCI 60 cell line panel. An unprecedented heterotrimeric complex has been observed to form between aplyronine A and actin and tubulin together, resulting in disruption of …
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Studies Towards a Second-Generation Synthesis of the Aplyronines
… origin, isolated from the Japanese sea hare Aplysia kurodai. They exhibit an exceptional biological activity profile, acting through an actin and tubulin dual-targeting mechanism, with subnanomolar growth inhibitory potency against a diverse range of cancer cell lines. These characteristics …
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Rationally designed aplyronine analogues for use in antibody-drug conjugates
The aplyronines are a family of antimitotic marine macrolides which show highly potent antiproliferative effects at picomolar concentrations in human cancer cell lines. Through a novel dual protein-targeting mechanism of action, their exquisite potency renders the aplyronines promising drug …