Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"apigenin"”.
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Preclinical Development of a Pharmacologic Agent for the Treatment of Recurrent Acute Pancreatitis
… (RAP), thereby limiting progression to CP. Apigenin is a natural compound with known anti-inflammatory, anti-proliferative, and pro-apoptotic properties. In a mouse model of RAP, the natural compound, apigenin, protected the pancreas from histologic damage while minimizing fibrosis. It was …
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Selecting dietary-derived bioactives which protect cartilage from destruction in osteoarthritis
… articular chondrocytes. Of these compounds, apigenin and isoliquiritigenin showed the greatest inhibition of MMP13 while also inhibiting MMP1, ADAMTS4 and ADAMTS5. The effect of apigenin or isoliquiritigenin pretreatment on three pathways implicated in OA, the NFκB, TGFβ and Wnt pathways was …
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Molecular mechanisms of bioactive compounds in fruits and vegetables that inhibit pancreatic cancer and their relationship with inflammation
… compounds tested, the flavonoids luteolin, apigenin, and quercetin had the highest inhibitory effects on GSK-3β activity, with 50% inhibitory values of 1.5, 1.9, and 2.0 µM, respectively. Molecular dockings were then performed to determine the potential interactions of each flavonoid with …
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ΣΥΜΒΟΛΗ ΣΤΗ ΜΕΛΕΤΗ ΤΩΝ ΧΗΜΙΚΩΝ ΣΥΣΤΑΤΙΚΩΝ ΤΩΝ ΦΥΛΛΩΝ ΤΟΥ ΦΥΤΟΥ PHLOMIS FRUTICOSA L.
… CHLOROGENIC ACID, CAFFEIC-1-GLUCOSIDE, APIGENIN-7-P- COUMAROYLGLUCOSIDE, CHRYSOERIOL-7-P-COUMAROYLGLUCOSIDE.
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The effect of UV-B radiation on flavonoid accumulation and gene expression in Marchantia polymorpha
… of which the flavones were the most predominant. Apigenin-based flavones were found in the highest amounts followed by luteolin-based flavones. The ratio of Apigenin to Luteolin-based flavones was seen to shift towards luteolin in high UV-B responses. Apigenin was suggested to be required for UV-B …
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Elucidating the roles of endothelial PTBP1 and PKM2 in Pulmonary Arterial Hypertension: implications for therapy
… treatment with the anti-tumorigenic compound apigenin, inhibits PTBP1 and PKM2 expression, in addition to lactate production, and functional parameters including cell proliferation and apoptosis susceptibility. I also confirm the therapeutic relevance of dimeric PKM2 to BOEC function, by …
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ΜΕΛΕΤΗ ΤΩΝ ΧΗΜΙΚΩΝ ΣΥΣΤΑΤΙΚΩΝ ΤΟΥ ΦΥΤΟΥ GALIUM MELANANTHERUM BOISS
… COMPOUNDS HAVE BEEN ISOLATED AND IDENTIFIED: APIGENIN, KAEMPFEROL, QUERCETIN., LUTEOLIN, CAFFEIC ACID, SCOPOLETIN, VITEXIN LUTEOLIN-7-0-B-GENTIOBIOSIDE, ORIENTIN, CHLOROGENIC ACID, ISOQUERCITRIN, NICOTIFLORIN (KAEMPFEROL-3-0-B- RUTTIN >RUTIN, ESCULETIN (IDENTIFIED BYHPLC BUT NOT ISOLATED). THE …
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PHARMACOKINETICS AND ORAL DELIVERY OF POLYMETHOXYLATED FLAVONES
… flavones, namely tangeretin (TAN), apigenin trimethyl ether (ATE), and luteolin tetramethyl ether (LTE), their pharmacokinetic profiles were assessed in Sprague-Dawley rats. Aqueous solubility has been identified a major barrier to their oral bioavailability. Subsequently, …
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Estrogenic and androgenic endocrine disrupting activity and risk assessment of phytoestrogens in Kenyan soya-based weaning flours
… the transcription activity of ten PEs (apigenin, daidzein, daidzin, genistein, genistin, enterodiol, equol, formononetin, glycitein and matairesinol) and in the Kenyan based gruel/flour extracts. A modified Hygiene Based Margin of Safety (HBMOS) method was used to estimate the …
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A study of the toxicological properties of propolis samples from Europe and Saudi Arabia and of their biological activity against protozoa
… (5), Galangin (6), Chrysin (7), Apigenin (8), Pinostrobin (9), Cinnamic acid (10), Coumaric acid cinnamyl ester (11a) and Coumaric acid benzylester (11b). Two compounds were isolated from Polish propolis namely 4', 7-Dimethoxykaempferol (12) and Naringenin 4', 7-dimethyl ether …
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Liganden des Benzodiazepin-Rezeptors: Studien über Benzodiazepine in pflanzlichen Geweben sowie über Hispidulin
… isoliert. Die BZD-R-aktiven Flavone wurden als Apigenin (5,7,4’-Trihydroxyflavon), Hispidulin (5,7,4’-Trihydroxy-6-methoxyflavon)und Cirsimaritin (5,4’-Dihydroxy-6,7-dimethoxyflavon identifiziert. Bei den diterpenoiden BZD-R-Liganden handelte es sich um 7-Methoxyrosmanol und Galdosol. Hispidulin …
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In vitro-Untersuchungen zu Inhaltsstoffen von Hypericum perforatum L. sowie topische Anwendung von Hypericum perforatum-Extrakten bei der Atopischen Dermatitis
… wir beim Luteolin, gefolgt von dem Flavonoid Apigenin, die größte proliferationshemmende Potenz der von uns untersuchten Johanniskrautinhaltsstoffe nachweisen. Die weiteren Substanzen wie Biapigenin, Amentoflavon, Myricetin, Epicatechin, Hyperosid, Kaffeesäure und Chlorogensäure zeigten keine …
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Study of Polyphenols and Naphthalimide Analogs As Inhibitors of Amyloid- β Protein Aggregation In Alzheimer'S Disease
… a group of polyphenols, including flavone, apigenin, luteolin, 3'4'-dihydroxyflavone and 5,7,3'4'5'-pentahydroxyflavone, was investigated for their ability to disrupt Aβ fibrils. Results indicate that these polyphenols do not disassociate Aβ fibrils but interrupt Aβ …
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Phytochemical diversity and genetics of purple corn
… of AR phytochemistry identified abundant apigenin-derived flavones that were found to copigment with anthocyanins, resulting in darker and bluer extracts and improved anthocyanin stability in a model beverage. Given the unique phytochemical diversity present in AR, a large-scale AR mapping …
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Combination Therapy For the Treatment of Human Malignant Neuroblastoma
… retinamide (4-HPR) and the flavonoid apigenin (APG) suppressed starvation-induced autophagy and triggered apoptosis. In our final combination strategy, we induced cellular differentiation in immature neuroblastoma cells by treating with a combination of 4-HPR and the Bcl-xL inhibitor …
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Tropical citrus antioxidants and catabolism of phenolics in green tea, coffee, cocoa and orange juice
… Among the major compounds detected were apigenin-6-8-di-C-glucopyranoside, apigenin-8-C-glucoside-2′-rhamnoside, phloretin-3′,5′-di-C-glucopyranoside, diosmetin-7-O-neohesperidoside, hesperetin-7-O-rutinoside, diosmetin-7-O-rutinoside and hesperetin-7-O-neohesperidoside. Most of the …
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Neurobiological effects of food fermentation-derived metabolites for metabolic and mental health
… assay to a panel of phenolic compounds. Apigenin and kaempferol (both flavonoids) significantly increased hippocampal cell proliferation. Moreover, to enhance the efficiency of data analysis, a semi-automatic quantification pipeline was developed for high-throughput screening of primary …
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Fabrication of self-assembled zein nanoparticles via microfluidic chip and ultrasonic treatment
… as curcumin, lycopene, lutein, resveratrol, and apigenin. However, these bioactive compounds have some challenges to be used in the food and pharmaceutical industries because of their poor solubility, poor bioavailability, and chemical instability. These limitations can be overcome by …
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Investigation of the antibacterial activity of selected flavonoids.
… polyphenon E (a green tea extract), galangin, apigenin and baicalin (naturally occurring flavonoids), and 3-O-octanoyl-(-)-epicatechin (a semi-synthetic flavonoid), were screened for inhibitory activity against antibiotic sensitive and resistant strains of Staphylococcus aureus, Enterococcus …
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