Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"apicoplast"”.
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Investigating the role of the Apicoplast in Plasmodium falciparum Gametocyte Stages
… Here, we have investigated the role of the apicoplast during Plasmodium falciparum gametocytogenesis. In addition, we describe drug-screening studies that have elucidated a novel mode of action of one compound from the Malaria Box, as well as identified new natural product compounds that may …
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Molecular target identification of antimalarial drugs using proteomic and metabolomic approaches
… was developed and validated. In addition, the apicoplast is an organelle present in the malaria parasite and other apicomplexan parasites. It was demonstrated that the apicoplast is essential for parasite's survival. The supply of isopentenyl diphosphate and dimethylallyl diphosphate for …
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Antimalarials from Plant Pathogenic Fungi
… inhibit the plant-like metabolic pathways in the apicoplast, a chloroplast-like organelle, essential for the survival of apicomplexan parasites, such as Plasmodium which cause malaria in humans. This dissertation describes the isolation, characterization, and biological evaluation of secondary …
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Lipoic acid protein ligases in Plasmodium spp.
… acid dependent enzyme complexes are found in the apicoplast, a plastid related organelle, and in the mitochondrion and thus two organelle specific lipoylation pathways are present in these parasites. Biosynthesis of the cofactor occurs in the apicoplast. Octanoyl-[acyl carrier protein]: protein …
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Functional analyses of Plasmodium Falciparum primary metabolic genes
… and used to locate mitochondrial-, nuclear-, and apicoplast-targeting signal peptides in CHO-K1 cells. Taken together, this study has validated a plausible interactive network of primary metabolic plasmodial genes.
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Using Evolutionary Genomics to Elucidate Parasite Biology and Host-Pathogen Interactions
… the algal source of the apicomplexan plastid (apicoplast), and animal-like genes that may have been acquired from these parasites’ host species. Studies on apicomplexan-specific expanded gene families indicate that kinases are a probable source of functional innovation. The T. gondii kinome …
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Genetic diversity of African isolates of Toxoplasma gondii
… distributed across seven chromosomes and the apicoplast genome of T.gondii, which improved the discrimination power to detect variation among the localUgandan strains. Although these markers were sufficient to separate global variationbetween T.gondii strains, they were not adequate to totally …
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Towards functional assignment of Plasmodium membrane transport proteins: an experimental genetics study on four diverse proteins
… that endogenously tagged FT2 localises to the apicoplast membranes, and is broadly expressed throughout the parasite‚Äôs life cycle. Strikingly, in two stages, schizonts and sporozoites, FT2 displays a dual localisation. Analysis of FT2-deficient parasites revealed a severe sporulation defect …
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Towards functional assignment of Plasmodium membrane transport proteins: an experimental genetics study on four diverse proteins
… that endogenously tagged FT2 localises to the apicoplast membranes, and is broadly expressed throughout the parasite‚Äôs life cycle. Strikingly, in two stages, schizonts and sporozoites, FT2 displays a dual localisation. Analysis of FT2-deficient parasites revealed a severe sporulation defect …
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Investigation of azithromycin analogues and proteasome-like inhibitors as quick-killing antimalarials
… malaria parasites remnant plastid organelle (the apicoplast’s) bacterial-like ribosome and causes slow-killing ‘delayed death’, where the parasite dies in the second replication cycle (4 days). Azithromycin has also been shown to inhibit invading merozoites and kill blood stages within the first …
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Kompartementalisierung des Kohlenhydrat-Stoffwechsels in Toxoplasma gondii
… die Zuordnung einzelner Isoenzyme zu Apicoplast, Mitochondrium und Zytosol im Vordergrund standen. Die Lokalisationen der in dieser Arbeit identifizierten Isoenzyme der Glykolyse, eines vollständigen Zitronensäure-Zyklus sowie weiterer, diesen Stoffwechselwegen angegliederter Enzyme, …