Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"aortic wall"”.
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Computational fluid dynamics as aid tool for the management of aortic wall diseases
Aortic aneurysms and dissections are pathological conditions affecting the aorta. Despite being different in clinical presentation, these pathologies share a high mortality rate, as well as a lack of reliable prognostic predictors. Local fluid dynamics is assumed to play a role in aortic …
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Bioprosthetic heart valves : ultrastructure and calcification
… St. Jude and Biocor. Due to the fact that the aortic wall component of these valves proved most resistant to all anticalcification treatments, aortic wall tissue stood in the centre of our analyses. 2) Subsequently, three main determinants of the fixation process namely: delay, temperature and …
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Novel strategies to increase Sirtuin-1 activity in aortic aneurysm
… and anti-oxidant effects on the aortic wall are involved in preventing vascular diseases, such as aortic aneurysm (AA) and dissection. We demonstrated that SirT1 in vascular smooth muscle (VSM), the major component of large arteries, is indispensable in maintaining vascular wall …
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The effects of bradykinin and angiotensin II on the thoracic aorta vasa sasorum microcirculation system
… a network of microvessels within and around the walls of large blood vessels and is thought to be necessary to deliver oxygenated blood to the outer parts of the vessel wall that are inadequately nourished by diffusion from luminal blood. Vasa vasorum flow, therefore, may play an important role …
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Characterization of Heterogeneous Material Properties of Aorta Using Nanoindentation
… and injuries. The heterogeneity of thoracic aortic tissue was characterized in terms of viscoelastic material properties and correlations were obtained between these properties and tissue morphology. Additionally, the effect of material preservation on the material properties was determined. …
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Deconvoluting genetic variants associated with aortic disease using stem cell models
Thoracic aortic disease (TAD) is usually silent until a catastrophic, life-threatening complication occurs. Identification and treatment at an early stage of disease can be informed by utilising genetic data, which in recent years has rapidly increased with the expansion of next-generation …
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Imaging microcalcium in thoracic aortic disease
… complications occur, such as stroke or aortic dissection. Current management strategies focus on preventative interventions which can include high-risk surgery. However, identifying those who are most appropriate for such interventions is challenging. Deposition of calcium crystals …
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Transcriptomic Analysis for the Identification and Prioritization of Treatment of Abdominal Aortic Aneurysms
Abdominal aortic aneurysms are pathological dilations of the abdominal aorta, characterized by a high mortality rate, and a lack of effective prognostic predictors. As the disease progresses, the aortic wall becomes significantly degraded and eventually the structure is compromised, leading to …
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Granulocyte Colony-Stimulating Factor Minimizes Negative Remodeling of Decellularized Small Diameter Vascular Graft Conduits but Not Medial Degeneration
… implanted with allograft infra renal abdominal aortic conduits were divided into 2 groups according to whether they were treated with G-CSF (+G-CSF group; n = 6) or without (Decell group; n = 6). The conduits were harvested at 8 weeks after surgery and examined for intimal hyperplasia, collagen …
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Mechanical Effects of Surgical Adhesives on Ascending Thoracic Aortic Aneurysm Replacement
<p>Ascending thoracic aortic aneurysm (aTAA) is a potentially lethal disease which grows gradually over time and may lead to aortic dissection and rupture. Currently, aTAA surgical repair using Dacron graft is a well-established treatment. In addition, surgical adhesives are frequently used in the …
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Optimizing interventions for the treatment of vascular flow disruptions
… of a tissue is impeded and viability is lost. Aortic stenosis is a paradigmatic example of vascular flow disruption. In health there is no gradient across the aortic valve and pressure generated in the left ventricle is transmitted without loss to the aorta. Pressure gradients across the valve …
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The effects of metformin on the vascular system
… measured using a Mulvany Halpern myograph. Mouse aortic ring sections were treated for 1 and 4 hours in vitro with metformin at 10-5M, and for 2, 4 and 8 weeks in vivo with metformin at 250mg/kg/day. The rings were contacted with increasing concentrations of noradrenaline (10-9M, 10-8M, 10-7M, …
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Shell finite elements, with applications in biomechanics
… clamping, and the modelling of a prosthetic aortic valve. In the case of the clamped artery, the deformed shape for a range of clamp depths compares well with results in the literature obtained using a three-dimensional formulation. The addition of helical fibre families orientated in the …
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Subclinical Atherosclerosis and Cognitive Functioning in a Population-Based Sample
… scores, coronary artery calcium (CAC), abdominal aortic plaque, and abdominal aortic wall thickness (AWT) was examined in the group as a whole, and in relation to age and ApoE4 allele status. Indirect measures of atherosclerosis (diabetes, hypertension, hypercholesterolemia, abdominal obesity) …
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The Role of Autophagy in the Pathogenesis and Clinical Course of Abdominal Aortic Aneurysms
Abdominal aortic aneurysm (AAA) is a permanent progressive focal dilation of the aorta that is â Ľ 50% of the normal aortic diameter, due to loss of wall structural integrity. A fatal outcome of the progressive dilation due to the compromised aortic wall integrity is rupture. Mortality associated …
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Histopathologische Untersuchungen von Aneurysmen der Aorta ascendens in Abhängigkeit von Aortenklappenvitien
… and granular media calcinosis (GMC) of ascending aortic aneurysms (AAA), which are associated with aortic stenosis (AS) or aortic regurgitation (AR). Additionally, a subanalysis of patients with bicuspid or tricuspid aortic valve (BAV or TAV), which were contained within the AS and AR group, was …
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Development of Novel Therapies for Marfan Syndrome using a Human iPSC-disease model
… severe cardiovascular complications, such as aortic aneurysms and dissection. Current treatments focus on surgically removing the aneurysm or on minimising aortic wall stress by controlling haemodynamics, but neither of these strategies tackle the underlying pathology. Although MFS is caused …
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Fibroblasts: Key Cells in Inflammation and Fibrosis
… normolipidimic mice leads to the development of aortic dissections and abdominal aortic aneurysm (AAA). IL-6 is a pro-inflammatory cytokine that is secreted by fibroblasts and macrophages in the aortic adventitia and promotes the development of aortic dissections. In our previous work, analysis …
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Anatomical study of the variation in the branching patterns and histology of the aorta in a South African population
… is limited. Histological changes in the aortic wall have been documented and may be due to pathology and physiological processes. Whether these changes are solely due to physiological processes such as haemodynamics or pathology is yet to be determined. The present study aims to document …
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