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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 77 for “"aortic valve"”.
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Comparison of patient outcome for aortic valve replacement verses transcatheter aortic valve replacement
Aortic stenosis or narrowing of the aortic valve is the most common cause for surgical valvular replacement in the United States. The disease of aortic stenosis has a long asymptomatic latency period followed by a quickly progressing symptomatic phase. Symptoms of the disease include dyspnea, …
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Stents for transcatheter aortic valve replacement
… heart disease (RHD) is the leading cause of aortic valve disease in the world. Surgery to repair or replace the diseased valves is the only means to save a patient's life once the disease becomes symptomatic. Transcatheter aortic valve replacement (TAVR) has revolutionised the treatment of …
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The design and prototyping of a Transcatheter Aortic Valve Implantation training system specific for aortic valve regurgitation.
Aortic regurgitation (AR) caused by rheumatic heart disease is a significant cause of mortality in developing countries. The replacement of the regurgitant aortic valve was historically performed by surgical insertion of a bioprosthetic or mechanical heart valve. Transcatheter Aortic Valve …
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UNRAVELLING SEX-DEPENDENT MECHANISMS IN CALCIFIC AORTIC VALVE STENOSIS
Calcific aortic valve stenosis (CAVS) is the most common form of heart valve disease and affects about 3% of the population. Its prevalence increases with age, without a causal relation between ageing and CAVS development. To date, CAVS is a slow, progressive, multifactorial disorder considered to …
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Fluid Dynamics Assessment of Transcatheter Aortic Valve Replacement Performance
Transcatheter aortic valve replacement (TAVR) an alternative therapy to standardized surgical aortic valve replacement (SAVR) in the treatment of severe symptomatic aortic stenosis has evolved greatly in the last decade based on results from successful clinical trials. These trials revealed …
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Transcatheter Aortic Valve Implantation: Risk Assessment and Clinical Outcome
Abstract Background: Transcatheter aortic valve implantation (TAVI) has emerged as a treatment for patients with aortic stenosis (AS) and high surgical risk. To date, reports of short- and mid-term survival have been favourable. The aim of this thesis was to evaluate early safety, risk assessment …
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Collagen structure within aneurysm tissue in bicuspid aortic valve patients
Aortic aneurysms pose a substantial clinical problem, especially in individuals with bicuspid aortic valve (BAV) disease, as aneurysm formation is 50% more common in these populations. Although the exact cause of aortic aneurysms in BAV patients is still unknown, a growing body of research points …
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Role of microRNA 214 in cyclic stretch induced aortic valve pathogenesis
Calcific aortic valve disease (CAVD) is one of the most prevalent valvular diseases among the elderly population. Unfortunately, there are no therapeutic drugs available to treat this disease. In this regard, mechanosensitive miRNAs have been considered as potential therapeutic candidates for CAVD, …
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Investigation into the genetic nature of familial congenital bicuspid aortic valve
Bicuspid aortic valve (BAV) affects approximately 1% of the general population and its etiology remains unknown. Based on literature reports, we hypothesized that congenital BAV (cBAV) was a developmental defect inherited as an autosomal dominant trait with variable penetrance. We evaluated the …
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Albumin Is Predictive of 1-Year Mortality After Transcatheter Aortic Valve Replacement
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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ELUCIDATION OF THE UNIQUE TRANSLATION OF ANGIOGENIC SIGNALING BY AORTIC VALVE CELLS
… a critical step in the progression of calcific aortic valve disease (CAVD). However, the process through which native valve cells, valve endothelial cells (VECs) and valve interstitial cells (VICs), form the neovascularization exhibited during CAVD is unclear due to their atypical translation of …
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Biomechanical and Molecular Approaches to Aortic Valve Disease in a Mouse Model
<p>Aortic valve disease (AVD) occurs in 2.5% of the human population and is a significant cause of cardiovascular mortality. Aortic valve malformation is a heritable condition that underlies the majority of cases, suggesting a developmental origin. Increased interstitial cell activation and …
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Molecular imaging of calcification and inflammation in aortic valve disease and atherosclerosis
Introduction. Calcific aortic valve disease (CAVD) and atherosclerosis are important public health problems. Our ability to allocate patients to treatment strategies optimally and monitor progression is limited. Hybrid positron emission and computed tomography (PET/CT) is able to demonstrate both …
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Effects of Mechanical Forces on the Biological Properties of Porcine Aortic Valve Leaflets
Cardiac valves are dynamic, sophisticated structures which interact closely with the surrounding hemodynamic environment. Altered mechanical stresses, including pressure, shear and bending stresses, are believed to cause changes in valve biology, but the cellular and molecular events involved in …
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Improving Preadmission Testing Nurses' Knowledge of Aortic Stenosis and Transcatheter Aortic Valve Replacement
… (PAT) nurses’ knowledge of severe/critical aortic stenosis (AS), transcatheter aortic valve replacement (TAVR) procedure and patient selection, and satisfaction with knowledge by 10%. Rapid growth of the TAVR program has contributed to a gap in nursing knowledge leading to inconsistent …
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Transcatheter aortic valve implantation: pre- and postoperative considerations to achieve patient-tailored therapy
Contains fulltext : 317682.pdf (Publisher’s version ) (Open Access)
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Modeling of Aortic Valve Anatomic Geometry from Clinical Multi Detector-Row Computed Tomography Images
Transcatheter aortic valve implantation (TAVI) is an emerging and viable alternative to surgical valve replacement. A TAVI procedure involves insertion of a catheter into the heart through an artery or transapically, and expanding valve stent in place. This procedure dramatically reduces the …
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The Surgical Management of Severe Aortic Stenosis In the Era of Transcatheter Aortic Valve Replacement
Transcatheter aortic valve replacement (TAVR) has emerged as a treatment option for severe and symptomatic aortic stenosis across the spectrum of surgical risk and has potentially transformed the surgical management of aortic stenosis. The objectives of this dissertation were: (1) To determine if …
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