Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"aortic smooth muscle cells"”.
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Effects of heparinoids on bovine aortic smooth muscle cells
Smooth muscle cells (SMCs) comprise the bulk of the tunica media of all blood vessels. Upon injury to the overlying endothelial monolayer of blood vessels, SMCs proliferate into the lumen of the vessel and cause dangerous occlusions. The glycosaminoglycan (GAG) heparin has been shown to be …
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The Effects of Ketoconazole on the Oxidation of Low Density Lipoproteins by Bovine Aortic Smooth Muscle Cells
Bovine aortic smooth muscle cells (BASMC) in culture have been shown to oxidatively modify human low-density lipoprotein (LDL). Such oxidized LDL appears to be a significant factor in the etiology of atherosclerosis. This work shows that the azole antifungal drug ketoconazole when added to the …
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Tetraspanin CD9: Contributions to Cancer Cell and Vascular Cell Phenotypes from the Sixth Man
… the actin arrangement and contraction of human aortic smooth muscle cells in a RhoA dependent manner. Taken together these provide insight on how tetraspanins regulate diverse cellular phenotypes.</p>
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MAP kinase phosphatase-2 in vascular smooth cell muscle function
… blood vessel; a process often driven by vascular smooth muscle cell hyperproliferation. A major mechanism by which smooth muscle cell proliferation occurs involves ligand-induced activation of MAP kinase signalling (Schad et al., 2011). MAP kinases have been noteworthy but troublesome targets in …
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The effect of cis-5,8,11,14,17-eicosapentaenoic acid upon the contractile mechanisms linked to calcium influx and the mobilisation of intracellular calcium in aortic smooth muscle
… that EPA partially blocked the contraction of aortic smooth muscle cells to the vasoactive agents KCl and noradrenaline. The latter effect was likely caused by reducing calcium influx through receptor-operated channels, supporting a recent suggestion by Asano et al (1997). Consistently, EPA …
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The role of altered cyclic strain patterns on proliferation and apoptosis of vascular smooth muscle cells - implications for in-stent restenosis
… the arterial wall predominantly due to vascular smooth muscle cells (SMC) migration from the media to the intima and subsequent SMC proliferation. A stent procedure dramatically alters the level of strains and stresses in the coronary artery and hence the mechanical environment of the SMC. We …
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Differentially expressed genes in aortic cells from atherosclerosis-resistant and atherosclerosis-susceptible pigeons
… White Carneau (WC) and Show Racer (SR) pigeon aortic smooth muscle cells. The gene(s) responsible for atherosclerotic resistance in cultured SR smooth muscle cells (SMC) were hypothesized to be silent or down regulated in the WC. In the reciprocal experiments, it was hypothesized that the …
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A Tissue-Engineered Microvascular System to Evaluate Vascular Progenitor Cells for Angiogenic Therapies
… cord blood-derived endothelial progenitor cells (hCB-EPCs) with mural cells can produce the microenvironmental cues necessary to support physiological microvessel formation in vitro; (2) poly(ethylene glycol) (PEG) hydrogel systems can support 3D microvessel formation by hCB-EPCs in …
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Pathways of intracellular protein degradation in cultured muscle cells
… responsible for the turnover of endogenous muscle protein, lysosomotropic proteinase inhibitors have been employed to elucidate the relative contributions of lysosomal and non-lysosomal degradation pathways functioning under varying nutritional states and for different classes of …
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Natural versus synthetic alpha-tocopherol using cell and animal models
… of cardiovascular diseases, we treated human aortic vascular cell lines with either natural or synthetic α-T (Chapter 2). We then stimulated cells with a pro-inflammatory cytokine (tumor necrosis factor-α, TNF-α), and measured the treatments’ effects on genes related to inflammation and …