Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"aortic disease"”.
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Imaging microcalcium in thoracic aortic disease
BACKGROUND: Disease of the thoracic aorta occurs in two major forms; atheroma and aneurysm formation. Both disease processes progress silently before catastrophic complications occur, such as stroke or aortic dissection. Current management strategies focus on preventative interventions which can …
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Deconvoluting genetic variants associated with aortic disease using stem cell models
Thoracic aortic disease (TAD) is usually silent until a catastrophic, life-threatening complication occurs. Identification and treatment at an early stage of disease can be informed by utilising genetic data, which in recent years has rapidly increased with the expansion of next-generation …
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Pharmacologic and Genetic Manipulations of Angiotensin Signaling In Thoracic Aortic Disease Models
<p>Thoracic aortic aneurysms and dissections (TAAD) are a major cause of morbidity and mortality in patients. Many different risk factors have been associated TAAD, but hypertension is the largest risk factor. Subsets of TAAD patients have identifiable syndromic genetic diseases, yet a number of …
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Targeting Metabolic Alterations Associated With Smooth Muscle Α-Actin Pathogenic Variant Attenuates Moyamoya-Like Cerebrovascular Disease
… muscle α-actin (α-SMA), predispose to thoracic aortic aneurysms and dissections. <em>De novo</em> missense variants disrupting <em>ACTA2 </em>arginine 179 (p.Arg179) cause a multisystemic disease termed smooth muscle dysfunction syndrome (SMDS), which is characterized by early onset thoracic …
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Studies into novel therapies for the treatment of inflammatory artery disease
The inflammatory artery diseases atherosclerosis and abdominal aortic aneurysm (AAA) are major causes of morbidity and mortality and there is significant attention towards identifying and targeting prominent inflammatory mediators underpinning these cardiovascular diseases. In the first chapter, …
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Effects of The Acta2 R258C Mutation On Vascular Smooth Muscle Cell Phenotype and Properties
<p>Thoracic Aortic Aneurysms and Dissections (TAAD) are the fifteenth leading cause of death in the United States. About 15% of TAAD patients have family history of the disease. The most commonly mutated gene in these families is <em>ACTA2</em>, encoding smooth muscle-specific α-actin. …
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Development of Novel Therapies for Marfan Syndrome using a Human iPSC-disease model
… severe cardiovascular complications, such as aortic aneurysms and dissection. Current treatments focus on surgically removing the aneurysm or on minimising aortic wall stress by controlling haemodynamics, but neither of these strategies tackle the underlying pathology. Although MFS is caused …
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Molecular Mechanisms of Vascular Disease In Patients With Rare Variants In Myh11
<p>Thoracic aortic aneurysms and dissections (TAAD) are the primary disease affecting the thoracic ascending aorta, with an incidence rate of 10.4/100,000. Although about 20% of patients carry a mutation in a single gene that causes their disease, the remaining 80% of patients may also have genetic …
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Mechanism of Rare Variant In Acta2, P.Arg149Cys, Driving Diverse Vascular Disease
… muscle (SM) α-actin) predispose to thoracic aortic aneurysms and dissections (TAAD) and early-onset coronary artery disease (CAD). The most common <em>ACTA2</em> mutation is a genetic alteration of arginine 149 to a cysteine, <em>ACTA2</em> p.Arg149Cys, which accounts for disease in 24% of …
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Imaging of abdominal aortic aneurysm disease activity and implications for endovascular aneurysm repair
BACKGROUND: Abdominal aortic aneurysm treatment pathways are initiated when an aortic size threshold of 55 mm is reached as this signifies a high annual risk of rupture due to presumed active aneurysm disease. Endovascular aneurysm repair (EVAR) is one treatment modality which reduces the …