Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"aortic banding"”.
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Einfluss von Celecoxib auf die Entstehung und den Verlauf einer kardialen Hypertrophie
… Bei Mäusen (C57BL/6NCrl), die durch ein Aortic-Banding einem erhöhten linksventrikulären (LV) Druck ausgesetzt wurden, konnte eine Celecoxib-Behandlung (50mg x kg-1 x d-1) sowohl die Entwicklung einer LV Dilatation als auch die kontraktile Funktionseinschränkung abmildern im Vergleich zu …
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Cardiac hypertrophy and the dynamic changes in structure and function after pressure overload
… size. It has been described that, following aortic banding, the γ isoform of p38MAPK translocates into the nucleus during the progression of cardiac hypertrophy, suggesting that this isoform of p38 may be involved in the synthesis of proteins involved in pathological remodelling (Dingar et …
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Dynamic Remodeling of The Stressed Heart: Role of Protein Degradation Pathways
… Sprague-Dawley rats were submitted to ascending aortic banding and sacrificed at 7 and 14 days after surgery. Sham operated animals served as controls. Effective aortic banding was confirmed by hemodynamic assessment by Doppler flow measurements in vivo. Banded rats showed a four-fold increase in …
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Multivariate analysis of transcriptional changes following restoration of SERCA2a levels in failing rat hearts
… SERCA2a but were natural adaptive responses to aortic banding needed for clinical non-failure, were identified and functionally categorized. Biological functional distribution of SERCA2a targets revealed that SERCA2a activates genes
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Effects of mutant SHP2 expression on heart function in Duchenne muscular dystrophy
… in SHP2 improves heart function after transverse aortic banding. I hypothesized that expression of a loss-of-function mutant SHP2 will improve heart function in DMD mice. To test this hypothesis, DMD mice (mdx4CV) were crossed with mutant SHP2 (Q510E-SHP2) mice, and we analyzed the compound …
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Artificial neural network models utilize chamber-specific predictors of cardiac fibrosis in ovariectomized and aortic-banded Yucatan mini-swine
… the loss of female sex hormones. Separately, aortic banding (AB) was used to induce pressure-overload and mimic HFpEF. Animals that did not undergo ovariectomy were assigned to the intact (INT) groups and animals that did not undergo AB were assigned as control (CON). b) Data: 24 six month old …
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Integrins and SPARC : potential implications for cardiac remodeling
… Modell der Drucküberlastung im Mausherzen (aortic banding; Konstriktion der Aorta; AB) eingesetzt, wobei Mäuse mit einer konditionalen, Herz-spezifischen Deletion des Integrin Beta 1 Gens untersucht wurden. Ein besonderes Augenmerk wurde dabei auf die physiologischen Unterschiede und eine …