Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"aortic arch"”.
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Range and frequency of AORTIC arch variants in a South African population
… study was to describe the range and frequency of aortic arch (AA) branching patterns using multi-detector computed tomography (MDCT). MDCT images of 400 patients who attended Groote Schuur Hospital between January 2013 and December 2014 for CT Chest and CT Thoracic angiogram were assessed. Six …
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Handedness and the geometry and hemodynamics of the branches of the aortic arch
… in the vasculature arising from the human aortic arch seems the obvious place to look for an anatomical basis for lateralized cerebral functions, but this relationship has never systematically been investigated. This study explored the relationship between handedness and the anatomical and …
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Fluid Flow Characterization and In Silico Validation in a Rapid Prototyped Aortic Arch Model
<p>Transcatheter aortic heart valve replacement (TAVR) is a procedure to replace a failing aortic valve and is becoming the new standard of care for patients that are not candidates for open-heart surgery [2]. However, this minimally invasive technique has shown to cause ischemic brain lesions, or …
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Engineered Tracking and Delivery of Mesenchymal Stem Cells (MSCs)
… negative control. Delivery of the cells into the aortic arch resulted in initial cell distribution throughout the entire body and engraftment in only the irradiated leg as detected by bioluminescent imaging (BLI). The biolumescence increased over time, indicating that the engrafted MSCs …
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Identifying Regional DNA Methylation Patterns in the Human Aorta in Health and Disease
The prevalence of a congenital bicuspid aortic valve (BAV) is 0.5 to 1% of the population. The condition arises from the fusion of two aortic valve leaflets and is commonly associated with progressive dilation of the aorta (aortopathy) which can lead to sudden and life-threatening complications …
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An analysis of the phenotypic features of chromosomes 22q11.1 deletion syndrome at Red Cross War Memorial Children's Hospital
… artery stenosis (20.8%) and interrupted aortic arch (6%). Interrupted aortic arch was found to be the most sensitive marker for 22qDS in children with cardiac lesions. The cardiac lesions with the highest positive predictive value for 22qDS was non-isolated VSD (54%). Dysmorphic features …
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3-DIMENSIONAL NUMERICAL AND EXPERIMENTAL STUDIES TO MODEL ARTIFICIAL HEART VALVES HEMODYNAMICS
… zones and shear stresses. In this research, we established a numerical model using arbitrary Lagrangian Eulerien to study the hemodynamic performance of a bileaflet mechanical heart valve. The 3-dimensional numerical simulation was performed using OpenFOAM, and validated experimentally …
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Common Arterial Trunk Repair at the Red Cross War Memorial Hospital, Cape Town: A 20-year review of surgical practice and outcomes
… 2018 at RCWMH. Patients with an interrupted aortic arch or previous pulmonary artery banding were excluded. RESULTS: Fifty-four patients had CAT repair during the study period. Thirty-four (63.0%) patients had a conduit repair, and 20 (37.0%) patients had a non-conduit repair. There were 2 …
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RNA-binding proteins mediate anti-inflammatory regulation of vascular disease
… muscle (VSMC) and endothelial cells (EC) of the aortic arch of Ldlr-/- mice, as compared to WT controls. EIF2α phosphorylation, requisite for SG formation, was also induced by clotrimazole and oxLDL in these cells. Interestingly, VSMCs pre-treated with anti-inflammatory cytokine IL-19 followed by …
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A Coupled CFD-Lumped Parameter Model of the Human Circulation: Elucidating the Hemodynamics of the Hybrid Norwood Palliative Treatment and Effects of the Reverse Blalock-Taussic Shunt Placement and Diameter
… to the innominate artery placed to counteract aortic arch stenosis, and its effects on local and global hemodynamics were studied. A synthetic and a 3D reconstructed, patient derived anatomy after the HN procedure were utilized, with varying degrees of distal arch obstruction, or stenosis, …
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Inverse problems in fluid dynamics for magnetic resonance velocimetry
… noisy synthetic images of 2D flow in a simulated aortic aneurysm. I then extend the method to noisy, sparsely-sampled signals, and test it for experimental flow through a converging nozzle. I find that the method is capable of reconstructing and segmenting the velocity fields from sparsely-sampled …
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Transcriptional Regulation of Cardio-Pulmonary Development
… of the right ventricle, the pharyngeal arches and limb buds. Loss of dHAND leads to apoptosis in the aforementioned tissues and to embryonic lethality at E10.0. A differential display analysis was performed to identify genes dysregulated in dHAND-/- hearts. Characterization of such genes …
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Studies into novel therapies for the treatment of inflammatory artery disease
… artery diseases atherosclerosis and abdominal aortic aneurysm (AAA) are major causes of morbidity and mortality and there is significant attention towards identifying and targeting prominent inflammatory mediators underpinning these cardiovascular diseases. In the first chapter, the role of the …
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The potential of sphingolipid depletion for the treatment of atherosclerosis
… Lesion inhibition was most pronounced at the aortic arch and distal sites of the thoracic and abdominal aorta. There was also a trend towards a reduction in lesion area at the aortic root. Myriocin treatment resulted in significant reductions in both plasma SM and GSL concentrations. Moreover, …
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Non-specific aortic arteritis (Takayasu's disease) : the Cape Town experience
Non-specific aortic arteritis remains a disease of unknown aetiology, in which the treatment is empiric, the indications for surgery controversial and the prognosis unpredictable. Most series emanate from the Far East, with few contributions from Africa. The pattern of disease as seen in-Cape Town …
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Origins of Systemic to Pulmonary Collateral Arteries and their Relative Frequencies in Patients with Pulmonary Artery Atresia or Stenosis as determined using Multidetector Computed Tomography Angiography
… and cardiothoracic surgeons in their search for SPC/s and to recommend an accurate, informative and standardised nomenclature system for SPC/s based on the relative frequency of SPC/s origins in patients with PA or PS identified using multi-detector computed tomography arteriography …
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Molecularly Targeted Nanoparticles for Modulation of Inflammatory Mediators in Atherosclerosis
… and an overall 22.5% decrease in aortic arch plaque deposition.</p><p>Future work on this platform would involve the improvement of dosing regimens that may address earlier time points of atherosclerosis development that may have a greater effect on induction of vascular …
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Vascular Effects of PHYSALIA PHYSALIS Venom
… Arterial pressure was measured from the aortic arch and the cranial femoral artery, a cephalad branch of the femoral artery. The skeletal muscle venous blood flow of the hind leg was functionally isolated. Femoral vein blood flow and pressure were monitored from ports in the …
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Newborn Pulse Oximetry Screening
The aim of this research was to develop an understanding of the burden and characteristics of critical congenital heart disease (CHD) in New Zealand and to establish whether it is feasible for New Zealand to introduce nationwide pulse oximetry screening for the detection of these anomalies in …
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A genome-wide, single-cell analysis of vascular smooth muscle cell plasticity
… VSMCs originating from the atherosclerosis-prone aortic arch and atherosclerosis-resistant descending thoracic aorta were found to have distinct transcriptional signatures at the single-cell level. Additionally, several disease-relevant genes were observed to be heterogeneously expressed within …
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