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Showing 1 to 20 of 40 for “"aortic aneurysms"”.
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THE ROLE OF CAVEOLAE IN THE FORMATION OF ABDOMINAL AORTIC ANEURYSMS
Abdominal aortic aneurysm (AAA) is a major cardiovascular disease and involves enhancement of renin-angiotensin system and recruitment/activation of inflammatory factors such as matrix metalloproteases (MMP's). Caveolae has been shown to play a role in a number of different cardiovascular diseases …
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Advanced computer modeling of abdominal aortic aneurysms to predict risk of rupture
An abdominal aortic aneurysm (AAA) is an abnormal enlargement of the aorta which is related to weakness of the vessel wall (associated with degradation of connective tissue), and if left untreated will lead to rupture and cause death in 78% to 94% of cases. Approximately 7,000 deaths each year in …
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Transcriptomic Analysis for the Identification and Prioritization of Treatment of Abdominal Aortic Aneurysms
Abdominal aortic aneurysms are pathological dilations of the abdominal aorta, characterized by a high mortality rate, and a lack of effective prognostic predictors. As the disease progresses, the aortic wall becomes significantly degraded and eventually the structure is compromised, leading to …
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Computational model of intraluminal thrombus growth in abdominal aortic aneurysms with fibrin generation
Abdominal aortic aneurysms affect 0.2% of the population and are closely associated with intraluminal thromboses (ILTs) that develop in the sac. Advanced imaging and treatment techniques are available, however there is room for improvement in the methods used to predict the outcome or necessity of …
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The Role of Autophagy in the Pathogenesis and Clinical Course of Abdominal Aortic Aneurysms
Abdominal aortic aneurysm (AAA) is a permanent progressive focal dilation of the aorta that is â Ľ 50% of the normal aortic diameter, due to loss of wall structural integrity. A fatal outcome of the progressive dilation due to the compromised aortic wall integrity is rupture. Mortality associated …
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Development of a novel uncovered stent system for the management of complex aortic aneurysms
Endovascular aortic repair (EVAR) is a minimally invasive alternative to open surgery for the treatment of aortic aneurysms (AA). However, standard EVAR is not applicable to complex AA with involvement of vital branches, which could be occluded by the endograft. As an emerging technique, the …
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The fate of proximally excluded iliac arteries following open repair of abdominal aortic aneurysms
Aneurysms occur throughout the length of the aorta, with a large proportion occurring in the infra-renal segment of the abdominal aorta (least 9 to 10 times more common than thoracic aortic aneurysms). Aneurysmal disease of the aorto-iliac segment which commonly occurs as a result of a degenerative …
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Characterizing A Novel Genetic Locus Associated With Familial Co-Occurrence of Thoracic Aortic Aneurysms and Intracranial Aneurysms
… been mapped for the familial form of Thoracic Aortic Aneurysms (TAA), and many causal mutations have been identified for this disease. Intracranial Aneurysms (ICA) also show linkage heterogeneity, but no mutations have been identified causing familial ICA alone. Here, we characterized a large …
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Abdominal aortic aneurysms : identification by self-examination and analysis of variation in matrix metalloproteinases with peak wall stress
Abdominal aortic aneurysms (AAAs) cause 5,000 deaths a year in the UK. Self-examination for AAAs may provide an economic and practical solution. Matrix metalloproteinase (MMP) concentration is elevated and levels of their natural inhibitors - Tissue Inhibitors of Matrix Metalloproteinases (TIMPs) …
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Towards An Understanding Of The Etiology Of Abdominal Aortic Aneurysms: Identification Of Genes Implicated In Aaa Risk And Development
<p>Abdominal aortic aneurysm (AAA) is a common disease for which mechanisms of formation are still not well understood. Despite a strong genetic component to AAA risk, specific risk alleles are still largely unidentified. AAA is also a localized disease with a majority occurring in the infrarenal …
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Development and Validation of Non-Invasive Methods for the Identification of Patient-Specific Hyperelastic and Anisotropic Material Properties of Abdominal Aortic Aneurysms In Vivo
An abdominal aortic aneurysm (AAA) is a permanent local dilatation of the human abdominal aorta, posing a severe health risk due to a rupture related mortality rate of up to 85 percent. Current clinical risk assessment relies on a population derived threshold value for the maximum aneurysm …
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Missed opportunities for the detection of abdominal aortic aneurysms : a retrospective study of eighteen patients presenting with a ruptured or acute symptomatic abdominal aortic aneurysm
A ruptured abdominal aortic aneurysm (AAA) has a mortality of 80 percent. The majority of these cases present as medical emergencies, with 50 percent dying before they reach hospital. Twenty percent are not operated on because of an incorrect diagnosis and of the surviving 30 percent, there will be …
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Novel molecular imaging of cardiovascular disease in man
… infarction or stroke, or rupture of abdominal aortic aneurysms. Conventional imaging modalities have consistently failed to identify atherosclerotic plaques or aneurysms with high-risk pathological features that are at highest risk of rupture or progression. The development of modern molecular …
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The Role of IL-6 in Inflammatory Aortic Aneurysmal Diseases
… vascular diseases including atherosclerosis and aortic aneurysms. Local vascular IL-6 secretion can be induced by dysregulated angiotensin II (Ang II) signaling, producing leukocyte infiltration that results in life-threatening aortic aneurysms and dissections. Precise mechanisms by which IL-6 …
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Pilvinės aortos aneurizmos automatinės detekcijos nauda matuojant aneurizmos tūrį. Literatūros apžvalga ir modelio sukūrimas /
For almost 20 years, aortic diameter has been the main parameter used not only for diagnosing aortic aneurysms, but also for surveillance, clinical decision-making and follow-ups after interventions. Despite its widespread use, diameter measurement has some relevant limitations. Therefore, aortic …
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Smooth Muscle Hyperplasia Due to Acta2/Myh11 Mutations: Identification of Novel Pathology and Pathways Leading to Aneurysms and Diverse Vascular Occlusive Diseases
… diverse vascular diseases, including thoracic aortic aneurysms and dissections (TAAD) and early onset coronary artery disease and stroke. The mechanism by which these mutations lead to dilatation of some arteries but occlusion of others is unknown. We hypothesized that the mutations act through …
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Collagen structure within aneurysm tissue in bicuspid aortic valve patients
Aortic aneurysms pose a substantial clinical problem, especially in individuals with bicuspid aortic valve (BAV) disease, as aneurysm formation is 50% more common in these populations. Although the exact cause of aortic aneurysms in BAV patients is still unknown, a growing body of research points …
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Large Artery Stiffness: Genes and Pathways
Aortic stiffness underlies systolic hypertension, promotes heart failure and is associated with in- creased cardiovascular morbidity and mortality. It is regarded as a primary driver of left ventricular hypertrophy and aortic aneurysms and is linked to the pathogenesis of cognitive impairment, …
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Peripheral Arterial Disease from Aetiology to Surgical Management
… on aneurysmal disease, specifically, abdominal aortic aneurysms (AAA), the clinical impact of which has had a bearing on the introduction of a National AAA Screening Program in Wales in 2013.<br/><br/>I conclude these sections with a collection of papers that reflect my long term commitment to …
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Fluid Flow Characterization and In Silico Validation in a Rapid Prototyped Abdominal Aortic Aneurysm Model
<p>Aortic aneurysms are the 14<sup>th</sup> leading cause of death in the United States. Annually, abdominal aortic aneurysm (AAA) ruptures are responsible for 4500 deaths. There are another 45,000 repair procedures performed to prevent rupture, and of these approximately 1400 lead to deaths. With …
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