Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 47 for “"antivirals"”.
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Synthesis of phosphorus/sulfur-based antivirals
… to the rapid mutation rate of the virus. Novel antivirals are continually required to combat evolving resistance. By making structural modifications to existing antiviral agents, the rate of antiviral incorporation into the viral DNA chain may be accelerated leading to more rapid termination of …
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Broad-spectrum antivirals against coronavirus using natural products and drug repurposing strategies
… rapid spread. While vaccines and virus-specific antivirals have been developed, emerging variants and novel pathogens underscore the importance of developing therapeutics with broader applicability. This thesis explores a dual strategy to expand the antiviral toolkit: natural product-based …
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Influenza Antivirals in Adults: Analyzing Usage Trends, GI Safety, and Cardiovascular Risk Reduction
… the aims of this dissertation: underuse of antivirals in high-risk adults, inconsistent findings on the risk of GI bleeding, and limited insight into the potential cardiovascular benefits of treatment. These knowledge gaps provide the rationale for the dissertation’s three specific aims. …
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Characterization of Innate Immune Mechanisms Against RVFV and a Potential Target for Antivirals
Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen, which affects both humans and livestock. RVFV belongs to the Bunyaviridae family, genus Phlebovirus and consists of a tripartite genome (L-, M- and S- segments). NSs, encoded in the S- segment promotes degradation of PKR and …
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Optimization of Signal-Detection Methods in Novel Databases: a Focus on Direct-Acting Antivirals
… of serious risks associated with direct-acting antivirals (DAAs): angioedema, dysglycemia, and hepatic decompensation and hepatic failure. The risk of angioedema or dysglycemia while on DAA therapy was identified through post-market surveillance, and prior studies did not include these two …
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TRIM5α is a poxvirus restriction factor: viral evasion strategies and a pathway to antivirals
This thesis describes cellular protein TRIM5α as a restriction factor for vaccinia virus (VACV) and two VACV countermeasures. This study followed up a proteomic analysis showing that VACV infection of TERT-immortalised human foetal foreskin fibroblasts (HFFF-TERTs) induced TRIM5 downregulation. …
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Toward the Rational Design of Better Antivirals: The Development of cGAMP as an HIV-1 Anti-Retroviral and the Genetic Surveillance of WNV Evolution
The innate immune response is the first line of defense against pathogens and thus represents the first hurdle viruses must overcome to cause severe disease in humans. Understanding the consequences of viral evolution can give insights to mechanisms of viral pathogenesis as well as the development …
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A Study of Human Coronavirus NL63: Characterization of Virus Replication, Targeting of Papain-Like Protease 2 by Antivirals and Probing Virus Mediated Innate Immune Antagonism
… syndrome. Currently no coronavirus-specific antivirals are available. Patients are given symptomatic treatment, or are prescribed inappropriately antibiotics which do not target the underlying virus infection. The identification of specific inhibitors of coronaviruses or knowledge about how …
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Exploring antiviral strategies: From innate immunity modulation to viral proteins targeting
… increasing yearly: until today over one hundred antivirals have been approved. The most common strategies to develop antiviral drugs are based on the identification of molecules targeting viral proteins and blocking viral replication as direct acting agents. Although successful, this strategy …
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Mechanistic Studies of Small Molecule Entry Inhibitors of Influenza A Viruses
… against influenza infections is the use of antivirals and, among those that are FDA approved, the prevalence of antiviral resistance is greatly concerning. Hence, it is crucial to develop anti-influenza inhibitors that exhibit strong effectiveness against novel viral targets. Considering the …
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Equilibrative Nucleoside Transporter Mediated Drug Disposition Across the Blood-Testis Barrier
… disposition of therapeutics across the BTB. Many antivirals and chemotherapeutic agents are classified as nucleoside analogs, which resemble endogenous nucleosides essential for nucleic acid synthesis and spermatogenesis. Due to similarity in chemical structure, these drugs are suspected to be …
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Allylic C—H activation to access anti-1,3-amino alcohol motifs
… of biologically active molecules including antivirals, antibiotics, antifungals, and various alkaloids. Due to their prevalence and utility as synthetic intermediates, a variety of methods have been developed to access these motifs in a diastereoselective fashion, which are outlined in …
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Comparative Respiratory Tract Pathology of Emerging Viral Infections
… could then be used to develop broad spectrum antivirals or vaccines. As such, we focused our studies on two recently emerged viruses, Nipah virus and the Middle East respiratory syndrome coronavirus (MERS-CoV), which have caused significant respiratory disease and death in humans.
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Modeling of Therapeutic Drugs, Polymers, and Self-Assembling Peptides
… peptides. A) We designed and investigated antivirals based on sulfoglycodendrimers and polystyrene sulfonate polymers of different topologies and sizes that can mimic heparan sulfate proteoglycans. We also investigated cucurbit[n]urils and small drugs capable of encapsulating charged viral …
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Fire fighters' ability and willingness to participate in a pandemic
… coverage, and availability of vaccines and antivirals. Collectively, these variables determine a workforce participation percentage (WPP) - the share of fire fighters who will be able and willing to participate in a response during a pandemic. Results indicate that between 30-70 percent of …
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Coronavirus Proteases as Therapeutic Targets: Development of Biosensors to Detect Inhibition of Protease Activity and Separation of the Multiple Functions of Coronavirus Papain-Like Proteases
… highlight the need for research to identify antivirals and vaccines against coronaviruses. To develop therapeutics against current and potentially emergent coronaviruses, I utilized two approaches targeting the proteases encoded within all coronaviruses. The papain-like protease and 3C-like …
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Elucidating the mechanisms and dynamics of drug-mediated inhibition and latency reversal in HIV-1 (HIV-1)
… reactivate latently infected cells, and of antivirals that can effectively inhibit re-establishment of infection post reactivation. This dissertation focuses on the evaluations of 2 classes of HIV-1 drugs, Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs), and LRAs, to better …
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Dengue Virus Host Factors
… facilitate the intelligent design of specific antivirals to combat the disease and enable the selective breeding of mosquitoes resistant to the virus. Although the genomes of the two primary mosquito vectors have been sequenced, the molecular tools necessary for conducting a systematic genetic …
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