Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"antiviral treatment"”.
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A study of immune responses during antiviral treatment for hepatitis C virus infection
… chronic hepatitis C infection. Interferon based antiviral therapies failed to recover HCV specific CD8+ T cell function suggesting that the damage to T cells may be permanent even after antigen removal. Chronically infected patients show poor response to treatment with pegylated interferon- and …
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Impact of highly active antiretroviral therapy on hepatitis C virus RNA levels over one year in HIV-HCV co-infected individuals.
… reconstitution with HAART, and then initiate HCV antiviral treatment in HIV-HCV co-infected individuals.
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Influenza Antivirals in Adults: Analyzing Usage Trends, GI Safety, and Cardiovascular Risk Reduction
This dissertation explores how influenza antiviral therapy is used in everyday clinical practice among U.S. adults, with a focus on its safety profile and potential cardiovascular benefits. Seasonal influenza remains a major public health concern, contributing to substantial morbidity, mortality, …
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Dengue Virus Host Factors
… the disease. Currently, no vaccine or specific antiviral treatment is available to combat this emerging menace. </p><p>A greater understanding of how dengue virus interacts with its insect and human hosts will facilitate the intelligent design of specific antivirals to combat the disease and …
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International Externalities in Pandemic Influenza Mitigation
… is to treat infectious individuals with antiviral pharmaceuticals. While most of the benefits from treatment accrue to the country in which treatment occurs, there are some positive spillovers: when one country treats more of its population this both reduces the attack rate in the other …
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Examination of type I IFN mediated regulation of the post-transcriptional antiviral response
… namely, Akt or PI-3'K, an IFN-α/β inducible antiviral response was abolished. Given the apparent importance of this pathway, we sought to enhance IFN-α/β signaling by targeting key negative regulatory intermediates. In vitro experiments demonstrated that cells lacking suppressors of …
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Incremental Cost of Hepatitis C Screening, Diagnosis and Treatment among People Who Inject Drugs in Kenya
… HCV related deaths globally. While Direct Acting Antiviral treatment has been known to eradicate the virus by 95%,15 only 23% people were diagnosed with the virus and 5% initiated treatment globally, by 2020. In Africa, of 10% diagnosed with the virus, 0.4% initiated treatment. In Kenya, there is …
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Prevalence of Hepatitis B in HIV infected persons: choice of antiretroviral therapy regimen and implications for screening
… therapy that were receiving optimal antiviral treatment, namely tenofovir and/or lamivudine. The relationship between Hepatitis B carriage and liver function was also determined in co-infected persons as measured by liver function tests. A cross sectional study was conducted from 30th …
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DISSECTION OF HOST-VIRUS INTERACTIONS IN THE HUMAN CENTRAL NERVOUS SYSTEM
… lead to severe neurological deficits, despite antiviral treatment. Neurotropic viruses cause viral encephalitis due to their ability to invade the central nervous system (CNS), and the most common cause is HSV-1. Inborn errors of immunity (IEIs) have demonstrated that neuron, cell …
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Detecting and defining immunity to human cytomegalovirus (HCMV) in health; combining QuantiFERON®-CMV and flow cytometry
… (PCR) and timely administration of pre-emptive antiviral treatment in the case of reactivation are vital to avert such outcomes. T-cell mediated immunity is key in controlling CMV infection and assays designed to measure it would improve the management of CMV infection in transplant patients; …
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Natural Killer Cell Responses in Chronic Hepatitis C Virus Infection
… who are unable to clear infection with antiviral agents. OBJECTIVE: Here we sought to characterize whether natural killer cells from individuals chronically-infected with hepatitis C virus respond in chronic HCV infection and to compare the frequencies of HCV-specific NK cell responses …
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Investigating synergy: Mathematical models for the coupled dynamics of HIV and HSV-2 and other endemic diseases
… may increase infectiousness. Accordingly, antiviral treatment of people with HSV-2 may mitigate the incidence of HIV in populations where both pathogens occur. To better understand the epidemiological synergy between HIV and HSV-2, we formulate, in Chapter 2, a deterministic compartmental …