Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"antiviral therapy"”.
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Mathematical Models of Hepatitis B Virus Dynamics during Antiviral Therapy
Antiviral therapy for patients infected with hepatitis B virus is only partially efficient. The field is in high demand for understanding the connections between the virus, immune responses, short-term and long-term drug efficacy and the overall health of the liver. A mathematical model was …
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EVALUATION OF THE HEPATIC MICROENVIRONMENT BEFORE AND AFTER ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS C
… recent therapeutic advances. Direct-acting antiviral (DAA) therapies have transformed clinical management, achieving cure rates exceeding 90% and significantly reducing complications such as hepatocellular carcinoma and mortality. However, challenges persist, including the absence of a …
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Influenza Antivirals in Adults: Analyzing Usage Trends, GI Safety, and Cardiovascular Risk Reduction
This dissertation explores how influenza antiviral therapy is used in everyday clinical practice among U.S. adults, with a focus on its safety profile and potential cardiovascular benefits. Seasonal influenza remains a major public health concern, contributing to substantial morbidity, mortality, …
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Entry of feline infectious peritonitis virus in blood monocytes
… to evaluate the presence of possible targets for antiviral therapy.
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Multidrug-Resistant Hepatitis B Virus Resulting From Sequential Monotherapy With Lamivudine, Adefovir, and Entecavir: Clonal Evolution During Lamivudine Plus Adefovir Therapy
… HBV clones that confer reduced sensitivity to antiviral therapy remains uncertain. This study investigated the evolution of MDR HBV strains developed from sequential monotherapy with lamivudine (LAM), adefovir (ADV), and entecavir (ETV) during LAM plus ADV salvage therapy. METHODS: Sera were …
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Dissecting the Contribution of the Carboxyl-Terminal Domain and Tail of HIV-1 Integrase to Viral Dynamics and Enzymatic Function
… Immune Deficiency Syndrome (AIDS). Combination antiviral therapy has proven to be particularly effective at suppressing viral replication, yet complete eradication of the virus from an infected individual remains elusive. Recently, a new class of antiviral drugs targeting the viral integrase …
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The Role of NS1-BP in Influenza Virus Replication
… interacting partners has major implications for antiviral therapy.
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Compartmental Hepatitis B Virus (HBV) Evolution, Replication and Infectivity in vivo and ex vivo
… the effect of nucleos/tide analogue (NA) therapy on HBV evolution and replication in different compartments (i.e., liver, plasma and peripheral blood mononuclear cell (PBMC)) is unknown, as well as the replicative competence and infectious capacity of PBMC-derived HBV. We hypothesize that …
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Analysis of cytomegalovirus UL97 drug resistance mutations in patients receiving Ganciclovir
… of intensive immunosuppression and prolonged antiviral therapy selects for the emergence of CMV UL97 drug resistance mutations.
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Subunit Interactions of Recombinant HIV-1 Reverse Transcriptase With Mutations at L289
… sites could lead to potential targets for antiviral therapy. In order to identify where subunit binding of RT occurs, mutations were made at leucine (L) 289, a residue believed to be involved in dimerization through hydrophobic interactions with other leucines. L289 is the central leucine …
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Repurposing the human immunodeficiency virus (HIV) integrase inhibitor raltegravir for the treatment of felid alphaherpesvirus 1 (FHV-1) ocular infection
… 1 (FHV-1), respectively. Rapid and effective antiviral therapy is of the utmost importance to control infection in order to preserve the vision of infected people or animals. However, current treatment options are suboptimal, in large part due to the difficulty and cost of de novo drug …
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Construction of an HIV-1 subtype C ventor system for phenotypic drug resistance studies
… (RT) and protease (PR) gene as targets of antiviral therapy has led to the discovery of various major, minor and polymorphic mutations harbored thereof. There are mutations in HIV-1 subtype B strains that develop only under drug pressure leading to ARV drug resistance. These mutations have …
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Efficiency of Monoclonal Antibodies to Detect Respiratory Virus Antigens in Clinical Specimens
<p>The development of specific antiviral therapy has increased the need for rapid viral diagnosis and necessitates a better understanding of viral epidemiology. The purposes of this study were to determine the efficiency of immunofluorescent assay employing monoclonal antibodies from commercial …
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The Dynamic Interplay Between Lentiviral Vif and Human APOBEC3 Proteins
… future efforts to disrupt this interaction as an antiviral therapy.
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Identification of novel cellular components associated with early HIV-1 nucleoprotein complexes
… HIV-1 infection represent potential targets for antiviral therapy. Despite extensive research the structure and composition of these structures remain poorly characterized. To better characterize these structures, two methods were developed to purify HIV-1 complexes for proteomic analysis and a …
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Challenges faced by HIV positive pregnant mothers in accessing ARVS : a case study of Tshirenzheni Village at Thulamela Municipality of Vhembe District
… a risk of the transmission of HIV, assessment of antiviral therapy for expectant mothers and her new baby. To arrive at the hospital at the advance stage of labour, these challenges included some .Ii socio demographic factors, that some women who tested positive drop out of PMTCT programmes for …
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A Role for Mindbomb 1 in Adenovirus Genome Delivery
… with the potential to inform the design of new antiviral treatments and emerging adenoviral vector-based therapies.</p>
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Meccanismi evolutivi dei parapoxvirus: caratterizzazione genomica di pseudocowpoxvirus e messa a punto di sistemi per lo studio delle ricombinazioni
… viral evolution and to improve the biosafety of antiviral therapy and PPV-based vectors.
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Dissecting Host-Viral Interactons Through Focused or Unbiased High-Throughput Genetic Approaches
… with potential significance for designing novel antiviral approaches. Next, I recount the mechanistic insights gained by studies performed in my thesis work using these approaches. Finally, I conclude by discussing potential therapeutic relevance of the insights uncovered by this thesis work.</p>