Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"antiviral signaling"”.
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Understanding Host Antiviral Signaling Pathways
… detect virally-derived nucleic acids and trigger signaling pathways which lead to the activation of transcription factors like nuclear factor-kappa B (NF-kappa B), interferon regulatory factor 3 (IRF3) and interferon regulatory factor 7 (IRF7). These transcription factors regulate the synthesis of …
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Single molecule investigation of antiviral signaling
… gene 1 (RIG-I) plays a major role in antiviral innate immunity by detecting cytoplasmic viral RNA and triggering the pathway that leads to transcriptional activation of type I interferon (IFN). Type I IFN induces a large set of genes called interferon-stimulated genes (ISGs) that …
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The Role of HOIL 1 Ubiquitin Ligase Activity in MDA5 Antiviral Signaling
… RIG-I and MDA5 both signal to MAVS to induce antiviral cytokine induction but respond to different viruses and are activated by distinct mechanisms. The mechanisms regulating RIG-I signaling has been extensively characterized, while considerably less Is known about MDA5 activation and signal …
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COCAINE AND HIV-1 REGULATE ASTROCYTE MITOCHONDRIAL ANTIVIRAL SIGNALING PROTEIN (MAVS) MEDIATED INFLAMMATION
… neurocognitive disorders (HAND). Cocaine impacts antiviral immune responses promoting increased inflammation. We previously demonstrated that cocaine increases DNA damage via oxidative stress and increases astrocyte antiviral immune responses. However, the mechanism by which cocaine induced …
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Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance
… demonstrate that cancer cells co-opt anti-viral signaling to sustain genetic programs that drive resistance to multiple anti-cancer modalities. In the context of radiation resistance, upon heterotypic interaction, exosomes are transferred from stromal to breast cancer (BrCa) cells and activate …
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Molecular insights into modulation of host innate immune response by viral proteins of RNA viruses SARS-CoV, HCV and Influenza virus
… (IFN), an innate immune response that generates antiviral state to prevent virus replication and spread by expressing several IFN-stimulated genes. Type I interferon response depends on a set of germ-line encoded receptors called pattern recognition receptors (PRRs) that initiate antiviral …
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Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease
… that HCV disrupts critical host intracellular antiviral signaling pathways that culminate in activation of the antiviral response. Using the cell-based replicon system, HCV was found to inhibit the activation of critical intracellular signaling pathways. Our studies identified the NS3/4A …
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Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease
… that HCV disrupts critical host intracellular antiviral signaling pathways that culminate in activation of the antiviral response. Using the cell-based replicon system, HCV was found to inhibit the activation of critical intracellular signaling pathways. Our studies identified the NS3/4A …
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Identification and Characterization of Auxiliary Factors in Innate Antiviral Immunity
… (RLRs) sense cytosolic viral RNAs and initiate signaling pathways culminating in the activation of IRF3 and subsequent type I interferon (IFN) antiviral response. This intrinsic protective mechanism is orchestrated by a host of positive and negative regulators, which collectively govern the …
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바이러스 감염시 미토콘드리아 E3 ubiquitin ligase 인 MARCH5의 새로운 생체 기능
… mitochondria membranes. First, the mitochondrial antiviral signaling (MAVS) protein forms aggregates that elicit robust type-I interferon induction on viral infection, but persistent MAVS signaling leads to host immunopathology; it remains unknown how these signaling aggregates are resolved. Here …
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POST-EXPOSURE TREATMENT OF MARBURG VIRUS ANGOLA DISEASE IN NON-HUMAN PRIMATES USING RECOMBINANT VESICULAR STOMATITIS VIRUS VECTORS
… helper differentiation, and genes mapping to antiviral responses and interferon signaling. In contrast, animals that succumbed had T helper 2 and regulatory T cell signatures; upregulation of genes associated with T-cell exhaustion; and delayed interferon signaling. Only survivor macaques …
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New Roles for Mitochondria in Shaping Antiviral and Stress Responses
… microbial infection, mitochondria serve as signaling hubs to induce immune responses to counteract invading pathogens like viruses. Mitochondrial functions are central to a variety of antiviral responses including apoptosis and type I interferon signaling (IFN-I). While apoptosis and IFN-I …
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Exploring antiviral strategies: From innate immunity modulation to viral proteins targeting
The search for new targets and antiviral agents is continuously growing, especially for agents with broad-spectrum activity. In fact, even though vaccines are the elective way to limit diseases and possibly eradicate pathogens, they are not always effective, particularly in people with compromised …
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Cellular responses to external threats probed by super-resolution microscopy
… cells triggers the immune response, a cascade of antiviral signaling proteins. For double stranded RNA (dsRNA) virus, the innate immune response starts from retinoic acid-inducible gene-I (RIG-I) protein which is a dsRNA sensor. For certain types of viruses, RIG-I localizes in cytoplasmic granular …
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Innate immune evasion and interferon antagonism by porcine epidemic diarrhea virus
… (IFN-λs) play a vital role to maintain the antiviral state of the mucosal epithelial surface in the gut. The intestinal epithelial cells selectively produce and respond to type III IFNs. To study the type III IFN response to PEDV, a line of porcine intestinal epithelial cells was developed …