Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"antiviral restriction factor"”.
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Are bats evolving more potent antiviral immune systems? Investigating the evolution and antiviral capacity of SERINC3 in Rhinolophus bats
… in a recent study has revealed a pattern of antiviral immune genes under positive selection across various bat species. One of these genes is the antiviral restriction factor SERINC3. The SERINC protein family is a collection of transmembrane proteins conserved amongst mammals. SERINC3 and …
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Functional Characterisation of Protein Degradation during Human Cytomegalovirus Infection
… can facilitate the development of novel antiviral therapies by restoring the activity of endogenous proteins important for antiviral restriction and immunity. A previous multiplexed proteomic approach identified 35 ‘high-confidence’ and 133 ‘medium-confidence’ host proteins that are …
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Proteomic Investigation of Interferon Alpha Stimulation and Viral Regulation to Identify Candidate Antiviral Restriction Factors
Antiviral restriction factors (ARFs) are host proteins that play key roles in inhibiting viral infection. The plasma membrane provides a critical interface between the cell and the virus, meaning that proteins present here are well situated to act as ARFs. An understating of these ARFs and how …
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Identification and Characterisation of Human Cytomegalovirus-Mediated Degradation of Helicase-Like Transcription Factor
Viruses are known to degrade host factors that are important in innate antiviral immunity in order to infect successfully. To systematically identify host proteins targeted for early degradation by human cytomegalovirus (HCMV), the lab developed orthogonal screens using high resolution multiplexed …
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Functional and Mechanistic Analysis of Protein Degradation by Human Cytomegalovirus to Uncover Viral Immune Evasion Mechanisms
… virus-host coevolution, viruses often antagonise antiviral host proteins by driving their downregulation, mislocalisation or inactivation. A quantitative proteomic analysis of HCMV infection published by our group found that at least 133 proteins are likely targeted for degradation by HCMV during …