Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"antiviral restriction"”.
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Proteomic Investigation of Interferon Alpha Stimulation and Viral Regulation to Identify Candidate Antiviral Restriction Factors
Antiviral restriction factors (ARFs) are host proteins that play key roles in inhibiting viral infection. The plasma membrane provides a critical interface between the cell and the virus, meaning that proteins present here are well situated to act as ARFs. An understating of these ARFs and how …
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Functional Characterisation of Protein Degradation during Human Cytomegalovirus Infection
… can facilitate the development of novel antiviral therapies by restoring the activity of endogenous proteins important for antiviral restriction and immunity. A previous multiplexed proteomic approach identified 35 ‘high-confidence’ and 133 ‘medium-confidence’ host proteins that are …
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Are bats evolving more potent antiviral immune systems? Investigating the evolution and antiviral capacity of SERINC3 in Rhinolophus bats
… in a recent study has revealed a pattern of antiviral immune genes under positive selection across various bat species. One of these genes is the antiviral restriction factor SERINC3. The SERINC protein family is a collection of transmembrane proteins conserved amongst mammals. SERINC3 and …
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The Intracellular Kinetics of HIV-1 Replication
… assembly, the virus-directed removal of the host restriction factor APOBEC3G, takes place within 2.5 hours following late gene expression. One of the major processes HIV-1 must complete before it can produce new virions is the clearance of antiviral restriction factors that can block the …
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Identification and Characterisation of Human Cytomegalovirus-Mediated Degradation of Helicase-Like Transcription Factor
… host factors that are important in innate antiviral immunity in order to infect successfully. To systematically identify host proteins targeted for early degradation by human cytomegalovirus (HCMV), the lab developed orthogonal screens using high resolution multiplexed mass spectrometry. …
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Interactions Between APOBEC3 and Murine Retroviruses: Mechanisms of Restriction and Drug Resistance
… deamination as an active source of viral restriction leading to hypermutation of viral DNA synthesized during reverse transcription. These mutations can result in viral lethality via disruption of critical genes, but in some cases is insufficient to completely obstruct viral replication. …
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Characterisation of Novel Secreted Antiviral Factors to Human Cytomegalovirus
… the virus includes the action of intrinsic antiviral restriction factors, NK cells, neutralising antibodies and polyfunctional CD4+ and CD8+ T-cells. Although critical roles have been established for the antiviral cytokines IFNγ and TNFα during HCMV infection, the contribution of soluble …
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Dissecting the Novel Roles of TRIM56 in Antiviral Innate Immunity
… proteins have emerged as a new class of host antiviral restriction factors, with several demonstrating roles in regulating innate antiviral responses. Of >70 known TRIMs, TRIM56 inhibits replication of bovine viral diarrhea virus, a ruminant pestivirus of the family <em>Flaviviridae</em>, but …
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Elucidating the Role of Phospholipid Scramblase 1 in Antiviral Innate Immunity
… normal host range. Understanding these intrinsic restriction factors and their mechanisms of action can help us understand how pathogens evolve to circumvent or oppose these factors, and identify those pathogens that might be poised to infect new species.In this thesis, I detail our findings that …
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Functional and Mechanistic Analysis of Protein Degradation by Human Cytomegalovirus to Uncover Viral Immune Evasion Mechanisms
… virus-host coevolution, viruses often antagonise antiviral host proteins by driving their downregulation, mislocalisation or inactivation. A quantitative proteomic analysis of HCMV infection published by our group found that at least 133 proteins are likely targeted for degradation by HCMV during …