Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"antiviral response"”.
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Antibody-Effector Functions in Antiviral Response
… by the quality and the magnitude of the immune response. The abundance of IgG glycoforms produced during an infection can vary greatly, modulating the immune effector repertoire throughout the course of infection. Notably, several studies have demonstrated the increase of afucosylated IgG …
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Optimization of influenza antiviral response in Texas
… to respond to potential influenza pandemics with antiviral, vaccine, and social interventions. Mathematical models can guide policies to saves lives. In this thesis, we create an optimization model, implemented in the online tool Texas Antiviral Release Scheduling (TAVRS) that provides the optimal …
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Chromatin Control of the Antiviral Response to Influenza
… to strongly impact gene function and the cell's response to the environment. Indeed, we were able to identify a novel pathway exploited by the influenza virus to directly dampen the host transcriptional response. The non-structural protein 1 (NS1) of the Influenza virus contains a histone H3-like …
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LUBAC is required for the RIG-I mediated antiviral response
… IRF3 and NF-κB, resulting in induction of an antiviral response. Early sensing of infection is essential for effective clearance of virus infection with minimal damage to the host. In this study we set out to understand the contribution of the linear ubiquitin chain assembly complex (LUBAC) to …
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Examination of type I IFN mediated regulation of the post-transcriptional antiviral response
… nearby cells and primes leukocytes for an immune response. A rapid response is necessary for effective control of virus replication and spread. Previously in our lab, the IFN-α/β inducible PI-3'K/mTOR mediated induction of translation was shown to operate in concert with the prototypical JAK/STAT …
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Influenza a virus gene expression heterogeneity regulates viral superinfection potential and host innate antiviral response
… influences viral superinfection and host innate antiviral response. To initiate productive infection, multiple SIPs must co-infect one cell to achieve complementation. Within a certain MOI range, increasing the abundance of SIPs in a viral population increases the percentage of productively …
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Characterizing global gene expression and antiviral response in Frankliniella occidentalis infected with Tomato spotted wilt virus
… the vector, and knowledge of transcriptome-wide response of thrips to TSWV has been limited. My research goals were to gain insight into i) the molecular responses that occur in thrips vectors of orthotospoviruses, ii) the role of antiviral defense in viruliferous thrips, and iii) plant …
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Hepatitis C Virus NS3/4A Protease and the Intracellular Antiviral Response: Mapping Complex Virus-Host Interactions
Virus infection triggers an innate immune response characterized by host cell production of interferon (IFN). Intermediates of viral replication, including dsRNA, initiate a signaling cascade that is amplified within the cell and alerts neighboring cells of viral invaders. Recognition of dsRNA …
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Comparative Study of Colon Cancer Subclones Uncovers Potential Roles for AKAP7 and TP53RK in the Antiviral Response.
… by OVs and the dysregulation of the interferon antiviral response in the CT26.lacZ cell line. Gene overexpression and gene silencing experiments suggest a functional role of these proteins in controlling viral growth. Further investigation of these genes and their relationship to antiviral …
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Poxvirus A51R Proteins Directly Bind to Microtubules to Antagonize Microtubule Dynamics, Intracellular Transport, and a Cell-intrinsic Antiviral Response
… interactions in the suppression of ROS-dependent responses in this cell type. While exploring the impact of A51R-MT interactions on MT functions, I discovered that WT A51R, but not the Triple mutant A51R, negatively regulates kinesin-1 function. Therefore, to my knowledge, this study presents the …
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ASSESSING AN M MUTANT VESICULAR STOMATITIS VIRUS FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME BY DETERMINING APOPTOTIC MECHANISMS AND ANTIVIRAL RESPONSE
… (M51R) VSV induced apoptosis and how innate antiviral responses affect infection of GBM tumor cells. When compared to controls, U-87 GBM tumor cells expressing a dominant negative form of Fas (dnFas) or over-expressing Bcl-XL had reduced caspase-3 activation following infection with M51R VSV …
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The Role of MDA5 and TLR3 in Response to dsRNA and Viral Infection
… signaling cascades leading to activation of the antiviral response. During the course of infection, many viruses produce dsRNA that can be recognized by two major arms of the innate immune system: the toll-like receptors: TLR) and the Rig-I-like receptors: RLR). Among the TLRs, TLR3 binds dsRNA …
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The Role of Interferon Stimlated Genes in Resistance and Immunity to Hepatitis C Virus Infection
… which plays a crucial role in the innate antiviral response through the regulation of interferon stimulated genes (ISGs). ISGs encode antiviral effector proteins that limit viral replication and spread. Hundreds of ISGs have been identified in the liver of HCV patients who respond to IFN …
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RESISTANCE TO VESICULAR STOMATITIS VIRUS IS INTRINSIC TO PC3 PROSTATE CANCER CELLS AND CAUSES INHIBITION OF EARLY STEPS OF THE VIRUS REPLICATION CYCLE
… is that PC3 cells constitutively overexpress antiviral mRNAs and proteins. Combined with the delays at several steps of the viral life cycle, these observations led to the two hypotheses tested in Chapter 2, which address whether PC3 cell resistance is intrinsic to these cells or whether it is …
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Isolation and characterisation of extracellular vesicles in baculovirus infection of insect cells
… derived virus to infect new insect hosts. The antiviral response of insects relies mainly on apoptosis and RNA interference (RNAi). In Drosophila melanogaster, following Sindbis virus infection, an RNAi signal was reportedly spread via extracellular vesicles (EVs). Extracellular vesicles …
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Identification and Characterization of Auxiliary Factors in Innate Antiviral Immunity
… of IRF3 and subsequent type I interferon (IFN) antiviral response. This intrinsic protective mechanism is orchestrated by a host of positive and negative regulators, which collectively govern the magnitude and duration of antiviral signaling. SRMS (Src-related kinase lacking C-terminal …
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Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease
… that HCV disrupts critical host intracellular antiviral signaling pathways that culminate in activation of the antiviral response. Using the cell-based replicon system, HCV was found to inhibit the activation of critical intracellular signaling pathways. Our studies identified the NS3/4A …
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Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease
… that HCV disrupts critical host intracellular antiviral signaling pathways that culminate in activation of the antiviral response. Using the cell-based replicon system, HCV was found to inhibit the activation of critical intracellular signaling pathways. Our studies identified the NS3/4A …
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Modulation of Alphaviruses by Small RNAs
… rely on small RNA pathways as an adaptive antiviral defense. The canonical antiviral response in these organisms involves dicer enzymes that cleave viral double-stranded RNA replicative intermediates (RIs) into small interfering RNAs (siRNAs; ~21-24 nucleotides). One strand of the siRNA …
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Viral and Host Genetic Determinants of Hepatitis C Virus Persistence and Interferon Resistance
… of genetic variants resistant to the host cell antiviral response and interferon (IFN)-based therapy. The development of the HCV RNA replicon system has allowed the study of persistent HCV RNA replication in tissue culture. We evaluated HCV/IFN interactions within a long-term culture system of …
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